The TLR4-IRE1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes.

scientific article

The TLR4-IRE1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JCMM.13636
P932PMC publication ID6010797
P698PubMed publication ID29673059

P50authorZhenyuan SongQ95283499
P2093author name stringLei Ding
Chen Shen
Songtao Li
Wang Ma
Xiaobing Dou
P2860cites workThe unfolded protein response: integrating stress signals through the stress sensor IRE1αQ24293771
TLR signaling pathwaysQ24570127
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondriaQ28573343
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritisQ28589300
Steatohepatitis: a tale of two "hits"?Q29547771
TLR4 links innate immunity and fatty acid-induced insulin resistanceQ29617577
Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulationQ33731432
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell deathQ33840334
Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistanceQ33840644
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cellsQ34152594
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell deathQ34564595
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
Mechanisms of lipotoxicity in NAFLD and clinical implicationsQ35132916
Lipotoxicity: when tissues overeatQ35168828
Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicityQ35827400
Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosisQ35939383
ER stress and the unfolded protein responseQ35986601
Toll-like receptor 4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic carcinoma cells.Q37018342
IRE1: ER stress sensor and cell fate executorQ37282044
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosisQ37446730
tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activationQ37448647
Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunityQ37456515
Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytesQ37625425
Ceramides - Lipotoxic Inducers of Metabolic DisordersQ38594138
Cell death induced by endoplasmic reticulum stress.Q38639996
TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathwayQ39218682
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in miceQ40612270
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.Q40816506
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and functionQ44328968
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acidsQ44514690
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathwayQ44967749
Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathwayQ45178588
Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator.Q54484656
Non-alcoholic fatty liver diseaseQ74052826
P433issue7
P921main subjecttoll-like receptorQ408004
P304page(s)3572-3581
P577publication date2018-04-19
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleThe TLR4-IRE1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes.
P478volume22

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cites work (P2860)
Q60919560Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms
Q91871195Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease
Q89104306Role of cAMP and phosphodiesterase signaling in liver health and disease
Q92049673Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
Q91526348Sodium fluorocitrate having inhibitory effect on fatty acid uptake ameliorates high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice
Q92300956The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

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