Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response

scientific article published on 14 May 2020

Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2020NatCo..11.2401D
P356DOI10.1038/S41467-020-15694-Y
P932PMC publication ID7224204
P698PubMed publication ID32409639

P50authorPeter WalterQ106367
Guido KroemerQ19508945
Eric ChevetQ56772239
Alexandra PapaioannouQ88526046
Matías González-QuirozQ94686248
Claudio HetzQ97544960
Pedro M. DomingosQ47135459
P2093author name stringHery Urra
Patricio Godoy
Alejandra Alvarez
José Manuel Bravo-San Pedro
Diego Acosta-Alvear
Amado Carreras-Sureda
Philippe Pihán
Daniela Gutierrez
Rémy Pedeux
Alvaro Glavic
Denisse Sepulveda
Eduardo A Sagredo
Younis Hazari
Gisela Campos
Cristian Valls
Alfredo I Sagredo
Estefanie Dufey
Cristian Eggers
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Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damageQ30441323
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α.Q47851339
PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.Q51665565
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DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signalingQ90376421
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergeticsQ92173184
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin AQ95595105
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clusteringQ30496639
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damageQ33977034
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.Q36000128
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Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in DrosophilaQ37381743
A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wingQ37424943
ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosisQ37536711
Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα.Q37561026
Getting RIDD of RNA: IRE1 in cell fate regulationQ38198370
The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.Q38309617
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Identification of a consensus element recognized and cleaved by IRE1 alpha.Q38343711
Therapeutic opportunities within the DNA damage responseQ38364665
Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis.Q38482230
Proteostasis control by the unfolded protein responseQ38540196
Protein misfolding in the endoplasmic reticulum as a conduit to human diseaseQ38704807
Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetesQ38852387
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimicQ38873500
Down-regulation of PERK enhances resistance to ionizing radiationQ39084540
ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.Q39097758
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
Autophagy and Mitophagy in Cardiovascular DiseaseQ39331287
Endoplasmic Reticulum Stress and the Hallmarks of CancerQ39456845
BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.Q39592117
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repairQ40347113
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathwayQ40916856
Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegansQ41608009
Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA libraryQ43064484
Etoposide prevents apoptosis in mouse liver with D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure resulting in reduction of lethalityQ43629442
The Unfolded Protein Response and Cell Fate ControlQ46394895
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.Q47104159
Dual IRE1 RNase functions dictate glioblastoma development.Q47223132
P4510describes a project that usesImageJQ1659584
RStudioQ4798119
P433issue1
P921main subjectgenotoxicityQ1009245
P304page(s)2401
P577publication date2020-05-14
P1433published inNature CommunicationsQ573880
P1476titleGenotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
P478volume11

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