Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.1200304
P932PMC publication ID423193
P698PubMed publication ID15175241
P5875ResearchGate publication ID8532069

P2093author name stringPeter J McKinnon
Christopher J Bakkenist
Michael B Kastan
Risa Kitagawa
P2860cites workFragments of ATM which have dominant-negative or complementing activityQ36567594
BRCA1 is a cell cycle-regulated nuclear phosphoproteinQ36648552
A mammalian protein complex that repairs double-strand breaks and deletions by recombination.Q38317518
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanismQ39896119
Monoclonal antibodies generated against recombinant ATM support kinase activityQ40853073
Independence of R/M/N focus formation and the presence of intact BRCA1.Q40864224
SMC proteins constitute two subunits of the mammalian recombination complex RC-1.Q41076499
The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasiaQ41609540
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiationQ44817175
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damageQ47759653
Cloning and characterization of mammalian SMC1 and SMC3 genes and proteins, components of the DNA recombination complexes RC-1.Q47981697
DNA replication-dependent nuclear dynamics of the Mre11 complex.Q53942975
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasiaQ62746091
Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damageQ72910633
Influence of ATM function on telomere metabolismQ73945587
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrestQ74355482
In vivo site-directed mutagenesis of yeast plasmids using a three-fragment homologous recombination systemQ74630929
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathwayQ22253899
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointQ24292395
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53Q24311891
BRCA1 supports XIST RNA concentration on the inactive X chromosomeQ24316340
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitroQ24656275
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damageQ24672492
Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae.Q27933169
Cohesins: chromosomal proteins that prevent premature separation of sister chromatidsQ27934146
The DNA damage response: putting checkpoints in perspectiveQ28131713
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AXQ28139663
ATM: genome stability, neuronal development, and cancer cross pathsQ28201456
The many substrates and functions of ATMQ28205055
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathwaysQ28207549
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damageQ28236024
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) miceQ28509807
Enhanced phosphorylation of p53 by ATM in response to DNA damageQ28609838
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaksQ28609912
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiationQ33558779
DNA damage-dependent nuclear dynamics of the Mre11 complexQ33975168
The Mre11 complex is required for ATM activation and the G2/M checkpointQ34052273
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiationQ34300338
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complexQ34311086
DNA damage induces phosphorylation of the amino terminus of p53Q35199554
Requirement of the MRN complex for ATM activation by DNA damageQ36267304
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)1423-1438
P577publication date2004-06-02
P1433published inGenes & DevelopmentQ1524533
P1476titlePhosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
P478volume18

Reverse relations

cites work (P2860)
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Q37194235miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells
Q39141299siRNA-mediated knockdown of SMC1A expression suppresses the proliferation of glioblastoma cells
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