scholarly article | Q13442814 |
P356 | DOI | 10.1038/NSMB1090 |
P698 | PubMed publication ID | 16622404 |
P2093 | author name string | Jean Gautier | |
Louise Boyer-Chatenet | |||
Aude Dupré | |||
P2860 | cites work | Protein phosphatase 2A is required for the initiation of chromosomal DNA replication | Q36753616 |
Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early development | Q38317558 | ||
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses | Q38336111 | ||
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. | Q40538990 | ||
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways | Q40750310 | ||
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway | Q40916856 | ||
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation | Q44817175 | ||
Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. | Q50722584 | ||
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. | Q51830570 | ||
The ATRs, ATMs, and TORs are giant HEAT repeat proteins. | Q55036334 | ||
Simulation of DNA fragment distributions after irradiation with photons | Q64388873 | ||
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest | Q74355482 | ||
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway | Q22253899 | ||
ATM-dependent phosphorylation of nibrin in response to radiation exposure | Q22254062 | ||
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint | Q24292395 | ||
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex | Q24298863 | ||
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks | Q24311761 | ||
Mre11 assembles linear DNA fragments into DNA damage signaling complexes | Q24796676 | ||
The rad50 signature motif: essential to ATP binding and biological function | Q27642866 | ||
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation | Q28206029 | ||
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints | Q28266170 | ||
Shelterin: the protein complex that shapes and safeguards human telomeres | Q28272546 | ||
ATM and related protein kinases: safeguarding genome integrity | Q29547735 | ||
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage | Q29614218 | ||
Specific recruitment of human cohesin to laser-induced DNA damage | Q30847802 | ||
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. | Q33863002 | ||
The Mre11 complex is required for ATM activation and the G2/M checkpoint | Q34052273 | ||
The MRN complex: coordinating and mediating the response to broken chromosomes | Q34250399 | ||
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex | Q34311086 | ||
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. | Q34347570 | ||
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models | Q34427548 | ||
Active role for nibrin in the kinetics of atm activation | Q34519762 | ||
The Mre11 complex: at the crossroads of dna repair and checkpoint signalling | Q34623788 | ||
DNA damage checkpoint and repair centers | Q35774210 | ||
Requirement of the MRN complex for ATM activation by DNA damage | Q36267304 | ||
P433 | issue | 5 | |
P304 | page(s) | 451-457 | |
P577 | publication date | 2006-04-23 | |
P1433 | published in | Nature Structural & Molecular Biology | Q1071739 |
P1476 | title | Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. | |
P478 | volume | 13 |
Q34728646 | A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex |
Q90592289 | A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers |
Q34722732 | ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks |
Q37870855 | ATM protein kinase: the linchpin of cellular defenses to stress |
Q34357377 | ATM signalling and cancer |
Q26777987 | ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor |
Q33283998 | ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis |
Q38248520 | ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends |
Q30444319 | ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication |
Q34722727 | Activation and regulation of ATM kinase activity in response to DNA double-strand breaks |
Q42793585 | Activation of protein kinase Tel1 through recognition of protein-bound DNA ends |
Q52878938 | Arabidopsis thalianaMRE11 is essential for activation of cell cycle arrest, transcriptional regulation and DNA repair upon the induction of double-stranded DNA breaks. |
Q39678828 | Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence |
Q39526815 | Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint |
Q30498797 | Autophosphorylation and ATM activation: additional sites add to the complexity |
Q33589782 | Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites |
Q59098643 | Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo |
Q34011429 | Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair |
Q40260293 | Changing of the guard: how ATM hands off DNA double-strand break signaling to ATR. |
Q92825167 | Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair |
Q36854289 | Chromatin dynamics and the preservation of genetic information |
Q33888520 | Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage |
Q38824449 | Coupling end resection with the checkpoint response at DNA double-strand breaks. |
Q33344436 | Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia |
Q88774888 | DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different |
Q38134064 | DNA damage sensing by the ATM and ATR kinases. |
Q36316482 | DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity |
Q39125363 | DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. |
Q30437599 | DNA double strand break repair enzymes function at multiple steps in retroviral infection |
Q91290605 | DNA repair functional analyses of NBN hypomorphic variants associated with NBN-related infertility |
Q36681945 | Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells |
Q37273198 | Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis |
Q55406533 | Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair. |
Q36229366 | Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis |
Q34431051 | Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing |
Q35096560 | Enhanced Tel1(ATM) checkpoint signaling at protein-bound double-strand breaks |
Q37672541 | FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance |
Q39208189 | Functions and regulation of the MRX complex at DNA double-strand breaks |
Q34089263 | H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy. |
Q38155902 | H2AX a promising biomarker for lung cancer: a review |
Q37643764 | Host DNA damage response factors localize to merkel cell polyomavirus DNA replication sites to support efficient viral DNA replication |
Q40199767 | Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection |
Q40179946 | Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies |
Q33293154 | Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains |
Q41295569 | Impact of the MRN Complex on Adeno-Associated Virus Integration and Replication during Coinfection with Herpes Simplex Virus 1. |
Q90470770 | Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection |
Q38270775 | Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance. |
Q52592808 | Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection. |
Q34972885 | Involvement of novel autophosphorylation sites in ATM activation |
Q38693768 | Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus |
Q38364071 | Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategies |
Q36413756 | Low doses of X-rays induce prolonged and ATM-independent persistence of γH2AX foci in human gingival mesenchymal stem cells. |
Q92671094 | MRE11A Isoform Expression Associated with Outcome Following Radiotherapy in Muscle-Invasive Bladder Cancer does not Alter Cell Survival and DNA Double-Strand Break Repair Following Ionising Radiation |
Q28116225 | MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response |
Q89719196 | Mathematical Model of ATM Activation and Chromatin Relaxation by Ionizing Radiation |
Q61450646 | Methodologies for Improving HDR Efficiency |
Q92285028 | Methods for Studying DNA Single-Strand Break Repair and Signaling in Xenopus laevis Egg Extracts |
Q38628212 | Modulation of p53 during bacterial infections |
Q59138338 | Molecular Mechanisms of H. pylori-Induced DNA Double-Strand Breaks |
Q36711288 | Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex. |
Q24644974 | Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity |
Q53569056 | Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework. |
Q33388649 | Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo |
Q36585497 | Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia |
Q34657712 | Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair |
Q30494441 | Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair |
Q33608879 | Origin-dependent initiation of DNA replication within telomeric sequences |
Q37392383 | PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin |
Q28583434 | Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death |
Q28239071 | RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function? |
Q27933110 | Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes |
Q36234704 | Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses |
Q34704848 | Rapid activation of ATM on DNA flanking double-strand breaks |
Q35928343 | Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. |
Q59791546 | Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors |
Q27310232 | Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors |
Q33886979 | Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications |
Q36945044 | Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability. |
Q42021074 | Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks |
Q27651403 | Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair |
Q92003387 | Structural insights into the activation of ATM kinase |
Q27681202 | Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling |
Q34522876 | Structure of the human dimeric ATM kinase |
Q38088935 | The ATM protein kinase: regulating the cellular response to genotoxic stress, and more |
Q36712849 | The ATM signaling network in development and disease |
Q34009427 | The DNA-damage response: new molecular insights and new approaches to cancer therapy |
Q47359487 | The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance |
Q30414183 | The MRN-CtIP pathway is required for metaphase chromosome alignment |
Q39761186 | The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage |
Q35309264 | Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase |
Q37693590 | Tip60: connecting chromatin to DNA damage signaling |
Q33894381 | To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres? |
Q91725146 | Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections |
Q34594349 | Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex |
Q40804262 | Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos |
Q39253075 | Xenopus egg extract: A powerful tool to study genome maintenance mechanisms |
Q34947114 | hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity |
Q33738564 | hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex |