Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

scientific article

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NSMB1090
P698PubMed publication ID16622404

P2093author name stringJean Gautier
Louise Boyer-Chatenet
Aude Dupré
P2860cites workProtein phosphatase 2A is required for the initiation of chromosomal DNA replicationQ36753616
Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early developmentQ38317558
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responsesQ38336111
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.Q40538990
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathwaysQ40750310
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathwayQ40916856
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiationQ44817175
Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.Q50722584
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains.Q51830570
The ATRs, ATMs, and TORs are giant HEAT repeat proteins.Q55036334
Simulation of DNA fragment distributions after irradiation with photonsQ64388873
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrestQ74355482
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathwayQ22253899
ATM-dependent phosphorylation of nibrin in response to radiation exposureQ22254062
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointQ24292395
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complexQ24298863
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaksQ24311761
Mre11 assembles linear DNA fragments into DNA damage signaling complexesQ24796676
The rad50 signature motif: essential to ATP binding and biological functionQ27642866
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpointsQ28266170
Shelterin: the protein complex that shapes and safeguards human telomeresQ28272546
ATM and related protein kinases: safeguarding genome integrityQ29547735
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageQ29614218
Specific recruitment of human cohesin to laser-induced DNA damageQ30847802
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.Q33863002
The Mre11 complex is required for ATM activation and the G2/M checkpointQ34052273
The MRN complex: coordinating and mediating the response to broken chromosomesQ34250399
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complexQ34311086
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.Q34347570
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse modelsQ34427548
Active role for nibrin in the kinetics of atm activationQ34519762
The Mre11 complex: at the crossroads of dna repair and checkpoint signallingQ34623788
DNA damage checkpoint and repair centersQ35774210
Requirement of the MRN complex for ATM activation by DNA damageQ36267304
P433issue5
P304page(s)451-457
P577publication date2006-04-23
P1433published inNature Structural & Molecular BiologyQ1071739
P1476titleTwo-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.
P478volume13

Reverse relations

cites work (P2860)
Q34728646A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
Q90592289A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers
Q34722732ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks
Q37870855ATM protein kinase: the linchpin of cellular defenses to stress
Q34357377ATM signalling and cancer
Q26777987ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor
Q33283998ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis
Q38248520ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends
Q30444319ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication
Q34722727Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
Q42793585Activation of protein kinase Tel1 through recognition of protein-bound DNA ends
Q52878938Arabidopsis thalianaMRE11 is essential for activation of cell cycle arrest, transcriptional regulation and DNA repair upon the induction of double-stranded DNA breaks.
Q39678828Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence
Q39526815Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint
Q30498797Autophosphorylation and ATM activation: additional sites add to the complexity
Q33589782Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
Q59098643Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
Q34011429Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair
Q40260293Changing of the guard: how ATM hands off DNA double-strand break signaling to ATR.
Q92825167Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair
Q36854289Chromatin dynamics and the preservation of genetic information
Q33888520Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
Q38824449Coupling end resection with the checkpoint response at DNA double-strand breaks.
Q33344436Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia
Q88774888DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different
Q38134064DNA damage sensing by the ATM and ATR kinases.
Q36316482DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
Q39125363DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues.
Q30437599DNA double strand break repair enzymes function at multiple steps in retroviral infection
Q91290605DNA repair functional analyses of NBN hypomorphic variants associated with NBN-related infertility
Q36681945Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells
Q37273198Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis
Q55406533Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.
Q36229366Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
Q34431051Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing
Q35096560Enhanced Tel1(ATM) checkpoint signaling at protein-bound double-strand breaks
Q37672541FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance
Q39208189Functions and regulation of the MRX complex at DNA double-strand breaks
Q34089263H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy.
Q38155902H2AX a promising biomarker for lung cancer: a review
Q37643764Host DNA damage response factors localize to merkel cell polyomavirus DNA replication sites to support efficient viral DNA replication
Q40199767Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection
Q40179946Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies
Q33293154Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains
Q41295569Impact of the MRN Complex on Adeno-Associated Virus Integration and Replication during Coinfection with Herpes Simplex Virus 1.
Q90470770Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection
Q38270775Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance.
Q52592808Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.
Q34972885Involvement of novel autophosphorylation sites in ATM activation
Q38693768Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus
Q38364071Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategies
Q36413756Low doses of X-rays induce prolonged and ATM-independent persistence of γH2AX foci in human gingival mesenchymal stem cells.
Q92671094MRE11A Isoform Expression Associated with Outcome Following Radiotherapy in Muscle-Invasive Bladder Cancer does not Alter Cell Survival and DNA Double-Strand Break Repair Following Ionising Radiation
Q28116225MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
Q89719196Mathematical Model of ATM Activation and Chromatin Relaxation by Ionizing Radiation
Q61450646Methodologies for Improving HDR Efficiency
Q92285028Methods for Studying DNA Single-Strand Break Repair and Signaling in Xenopus laevis Egg Extracts
Q38628212Modulation of p53 during bacterial infections
Q59138338Molecular Mechanisms of H. pylori-Induced DNA Double-Strand Breaks
Q36711288Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.
Q24644974Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
Q53569056Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework.
Q33388649Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo
Q36585497Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia
Q34657712Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair
Q30494441Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair
Q33608879Origin-dependent initiation of DNA replication within telomeric sequences
Q37392383PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin
Q28583434Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
Q28239071RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?
Q27933110Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes
Q36234704Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses
Q34704848Rapid activation of ATM on DNA flanking double-strand breaks
Q35928343Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
Q59791546Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors
Q27310232Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors
Q33886979Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications
Q36945044Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.
Q42021074Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks
Q27651403Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair
Q92003387Structural insights into the activation of ATM kinase
Q27681202Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling
Q34522876Structure of the human dimeric ATM kinase
Q38088935The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Q36712849The ATM signaling network in development and disease
Q34009427The DNA-damage response: new molecular insights and new approaches to cancer therapy
Q47359487The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
Q30414183The MRN-CtIP pathway is required for metaphase chromosome alignment
Q39761186The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage
Q35309264Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase
Q37693590Tip60: connecting chromatin to DNA damage signaling
Q33894381To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?
Q91725146Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections
Q34594349Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex
Q40804262Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos
Q39253075Xenopus egg extract: A powerful tool to study genome maintenance mechanisms
Q34947114hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
Q33738564hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex