| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Peter J McKinnon | |
| Sachin Katyal | |||
| P2860 | cites work | Tissue- and site-specific DNA recombination in transgenic mice | Q21999077 |
| Neurodegeneration: nicked to death | Q79616731 | ||
| Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7 | Q81484825 | ||
| The role of double-strand break repair — insights from human genetics | Q22122018 | ||
| Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 | Q24297360 | ||
| Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation? | Q24298259 | ||
| Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly | Q24302120 | ||
| XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining | Q24302150 | ||
| The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates | Q24302254 | ||
| The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4 | Q24304499 | ||
| ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage | Q24306743 | ||
| RP2 and RPGR mutations and clinical correlations in patients with X-linked retinitis pigmentosa | Q24532214 | ||
| Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice | Q24548104 | ||
| Accelerated telomere shortening in response to life stress | Q24559314 | ||
| Ligand-activated site-specific recombination in mice | Q24600193 | ||
| Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance | Q24672646 | ||
| Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ | Q27649166 | ||
| Crystal structure of human XLF: a twist in nonhomologous DNA end-joining | Q27649427 | ||
| ATM and ATR: networking cellular responses to DNA damage | Q28143424 | ||
| Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene | Q28190293 | ||
| The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin | Q28190324 | ||
| Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy | Q28203189 | ||
| Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair | Q28206244 | ||
| Molecular views of recombination proteins and their control | Q28207872 | ||
| Defective DNA repair and neurodegenerative disease | Q28250196 | ||
| Non-homologous end-joining, a sticky affair | Q28260337 | ||
| NBS1 and its functional role in the DNA damage response | Q28274249 | ||
| A new chromosomal instability disorder: the Nijmegen breakage syndrome | Q28281429 | ||
| A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis | Q28292871 | ||
| DNA double-strand break repair: from mechanistic understanding to cancer treatment | Q28293130 | ||
| Cell-cycle checkpoints and cancer | Q28293996 | ||
| Neurotrophin-3 is required for proper cerebellar development | Q28505292 | ||
| Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age | Q28505636 | ||
| DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway | Q28506076 | ||
| Mechanisms of disease: DNA repair defects and neurological disease | Q36753339 | ||
| ATM activation and DNA damage response | Q36800838 | ||
| The ATR pathway: fine-tuning the fork | Q36832714 | ||
| Replication and protection of telomeres | Q36854279 | ||
| DNA repair deficiency and neurodegeneration | Q36910865 | ||
| DNA strand break repair and human genetic disease | Q36948676 | ||
| Processing of nonconventional DNA strand break ends | Q36975842 | ||
| The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome. | Q37027197 | ||
| Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling | Q38632163 | ||
| The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex | Q40146555 | ||
| DNA end joining activity is reduced in Alzheimer's disease | Q40419228 | ||
| Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway | Q40916856 | ||
| Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart | Q41689524 | ||
| Nature of mitochondrial DNA deletions in substantia nigra neurons | Q43058638 | ||
| Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. | Q46590824 | ||
| The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage | Q47602742 | ||
| Age-related base excision repair activity in mouse brain and liver nuclear extracts | Q48366001 | ||
| Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons | Q48588748 | ||
| Studies on genomic DNA topology and stability in brain regions of Parkinson's disease | Q48591209 | ||
| Purkinje cell loss in the cerebellar flocculus in patients with ataxia with ocular motor apraxia type 1/early-onset ataxia with ocular motor apraxia and hypoalbuminemia. | Q50896438 | ||
| Dual roles of ATM in the cellular response to radiation and in cell growth control. | Q52521591 | ||
| Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. | Q52542455 | ||
| An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. | Q52943096 | ||
| Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. | Q53263839 | ||
| The cellular response to DNA double-strand breaks: defining the sensors and mediators | Q63383934 | ||
| Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype | Q63681777 | ||
| An essential function for NBS1 in the prevention of ataxia and cerebellar defects | Q28507300 | ||
| DNA repair is limiting for haematopoietic stem cells during ageing | Q28509105 | ||
| TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo | Q28509265 | ||
| Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice | Q28509807 | ||
| Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice | Q28510493 | ||
| Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells | Q28513366 | ||
| Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development | Q28585656 | ||
| BRCA2 is required for neurogenesis and suppression of medulloblastoma | Q28590758 | ||
| Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis | Q28594255 | ||
| ATM and related protein kinases: safeguarding genome integrity | Q29547735 | ||
| TopBP1 activates the ATR-ATRIP complex | Q29614214 | ||
| Inducible gene targeting in mice | Q29614544 | ||
| Telomeres and human disease: ageing, cancer and beyond | Q29615353 | ||
| High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease | Q29619113 | ||
| Atm-deficient mice: a paradigm of ataxia telangiectasia | Q29619532 | ||
| Disorders of cerebellar growth and development | Q31076477 | ||
| AGEMAP: a gene expression database for aging in mice | Q33310467 | ||
| Linking DNA damage and neurodegeneration | Q34001971 | ||
| The Mre11 complex is required for ATM activation and the G2/M checkpoint | Q34052273 | ||
| Genetic regulation of cerebellar development | Q34082679 | ||
| A murine model of Nijmegen breakage syndrome | Q34124812 | ||
| Autozygosity mapping of a seckel syndrome locus to chromosome 3q22. 1-q24. | Q34142158 | ||
| ATM and ataxia telangiectasia | Q34166198 | ||
| Gene regulation and DNA damage in the ageing human brain | Q34326236 | ||
| Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms | Q34343834 | ||
| Organismal stress and telomeric aging: an unexpected connection | Q34373546 | ||
| DNA repair, genome stability, and aging | Q34398207 | ||
| Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models | Q34427548 | ||
| Rapid accumulation of genome rearrangements in liver but not in brain of old mice | Q34449310 | ||
| Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system | Q34467644 | ||
| Cell aging in relation to stress arousal and cardiovascular disease risk factors | Q34468856 | ||
| The aging brain: accumulation of DNA damage or neuron loss? | Q34474172 | ||
| DNA double-strand break repair: all's well that ends well | Q34555274 | ||
| Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter | Q34612904 | ||
| Synapse formation on neurons born in the adult hippocampus. | Q34626268 | ||
| Conditional mouse models of sporadic cancer | Q34632032 | ||
| Changes in DNA repair during aging. | Q34697935 | ||
| A role for adult TLX-positive neural stem cells in learning and behaviour | Q34743630 | ||
| Getting around lethality with inducible Cre-mediated excision | Q34749679 | ||
| The cells and molecules that make a cerebellum. | Q34752211 | ||
| When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease | Q35050109 | ||
| The age of cancer: telomeres, checkpoints, and longevity | Q35104336 | ||
| Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice | Q35109704 | ||
| Histone H2AX in DNA damage and repair. | Q35184065 | ||
| XRCC1 and DNA strand break repair | Q35216366 | ||
| Mechanism and regulation of human non-homologous DNA end-joining | Q35542018 | ||
| Repair of DNA double strand breaks by non-homologous end joining | Q35630367 | ||
| Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells | Q35721509 | ||
| Transcripts of aging | Q35774486 | ||
| Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis | Q35848561 | ||
| An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome | Q35848567 | ||
| Early events in the DNA damage response | Q35944680 | ||
| Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment | Q36059507 | ||
| Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity | Q36103535 | ||
| Requirement of the MRN complex for ATM activation by DNA damage | Q36267304 | ||
| RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis? | Q36389652 | ||
| Responding to DNA double strand breaks in the nervous system | Q36578120 | ||
| Ataxia-telangiectasia and related diseases | Q36617706 | ||
| DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. | Q36625543 | ||
| The mechanics of base excision repair, and its relationship to aging and disease | Q36656724 | ||
| The contribution of the DNA damage response to neuronal viability | Q36658158 | ||
| DNA repair in aging rat neurons | Q36677818 | ||
| Pleiotropic defects in ataxia-telangiectasia protein-deficient mice | Q36687853 | ||
| Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases. | Q36731653 | ||
| P433 | issue | 7-8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | neurodegeneration | Q1755122 |
| P304 | page(s) | 483-491 | |
| P577 | publication date | 2008-03-25 | |
| P1433 | published in | Mechanisms of Ageing and Development | Q1839797 |
| P1476 | title | DNA strand breaks, neurodegeneration and aging in the brain | |
| P478 | volume | 129 |
| Q39472818 | ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy |
| Q27323759 | Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1 |
| Q52653014 | CSA and CSB play a role in the response to DNA breaks. |
| Q41925281 | Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. |
| Q36853151 | Comet assay analysis of single-stranded DNA breaks in circulating leukocytes of glaucoma patients. |
| Q26744282 | Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure |
| Q38820530 | DNA Damage in Major Psychiatric Diseases |
| Q34477972 | DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease |
| Q38230583 | DNA damage and its links to neurodegeneration |
| Q37368873 | DNA repair deficiency and neurological disease |
| Q35878514 | Disconnecting XRCC1 and DNA ligase III |
| Q39101393 | Effects of DSP4 on the noradrenergic phenotypes and its potential molecular mechanisms in SH-SY5Y cells |
| Q36661396 | Effects of expression level of DNA repair-related genes involved in the NHEJ pathway on radiation-induced cognitive impairment |
| Q92539630 | Exonic Variants in Aging-Related Genes Are Predictive of Phenotypic Aging Status |
| Q42007265 | Expression Levels of Two DNA Repair-related Genes under 8 Gy Ionizing Radiation and 100 Mg/Kg Melatonin Delivery In Rat Peripheral Blood |
| Q34375370 | Half a pack of cigarettes a day more than doubles DNA breaks in circulating leukocytes |
| Q34974240 | Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death |
| Q36561981 | ISG15 deregulates autophagy in genotoxin-treated ataxia telangiectasia cells |
| Q39697606 | Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. |
| Q41851979 | Inhibitors of histone deacetylases enhance neurotoxicity of DNA damage |
| Q37603313 | Lithium promotes DNA stability and survival of ischemic retinal neurocytes by upregulating DNA ligase IV. |
| Q50778929 | Long-lasting effects of maternal separation on an animal model of post-traumatic stress disorder: effects on memory and hippocampal oxidative stress. |
| Q84988816 | Manganese inhibits poly(ADP-ribosyl)ation in human cells: a possible mechanism behind manganese-induced toxicity? |
| Q34573986 | Markers of apoptosis induction and proliferation in the orbitofrontal cortex in alcohol dependence. |
| Q34188468 | Milestones in ataxia |
| Q52770281 | Minocycline increases the activity of superoxide dismutase and reduces the concentration of nitric oxide, hydrogen peroxide and mitochondrial malondialdehyde in manganese treated Drosophila melanogaster. |
| Q39180806 | Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response |
| Q28115978 | NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability |
| Q37701241 | Neurodegeneration-associated instability of ribosomal DNA. |
| Q34121353 | Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition |
| Q42031023 | Nucleolar disruption and apoptosis are distinct neuronal responses to etoposide-induced DNA damage |
| Q37858347 | Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword |
| Q35957287 | Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. |
| Q38022936 | Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes |
| Q37421869 | Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease. |
| Q34999535 | Recent advances in our understanding of neurodegeneration |
| Q27309426 | Requirement of mouse BCCIP for neural development and progenitor proliferation |
| Q30235289 | Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer |
| Q37778035 | Spinocerebellar Ataxia with Axonal Neuropathy |
| Q41828864 | Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin |
| Q51038697 | The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State? |
| Q27861055 | The DNA Damage Response: Making It Safe to Play with Knives |
| Q37230090 | The effect of ranibizumab versus photodynamic therapy on DNA damage in patients with exudative macular degeneration. |
| Q37873608 | The role of IκB kinase complex in the neurobiology of Huntington's disease |
| Q35164644 | Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage |
| Q36882294 | p53-dependent SIRT6 expression protects Aβ42-induced DNA damage |
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