DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

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DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1024870626
P356DOI10.1186/1750-1326-5-60
P932PMC publication ID3018387
P698PubMed publication ID21172027
P5875ResearchGate publication ID49696531

P2093author name stringYan Yang
Jianmin Chen
Alan J Lerner
Karl Herrup
Mark L Cohen
P2860cites workCerebellar atrophy in Alzheimer's disease-clinicopathological correlations.Q48301846
Motor impulsivity in APP-SWE mice: a model of Alzheimer's diseaseQ48434143
Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.Q48487273
Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease.Q48696767
Purkinje cell loss and astrocytosis in the cerebellum in familial and sporadic Alzheimer's diseaseQ48941742
Atypical amyloid (A beta) deposition in the cerebellum in Alzheimer's disease: an immunohistochemical study using end-specific A beta monoclonal antibodies.Q53213182
Maintenance of balance, gait patterns, and obstacle clearance in Alzheimer's disease.Q53312841
Motor dysfunction in mildly demented AD individuals without extrapyramidal signs.Q53337310
Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's diseaseQ57306430
Neuronal Loss in the Brainstem and Cerebellum--Part of the Normal Aging Process? A Morphometric Study of the Vermis Cerebelli and Inferior Olivary NucleusQ60597025
Alzheimer's disease: amyloid plaques in the cerebellumQ69360918
Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse modelsQ82297941
Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?Q22337222
Aneuploid neurons are functionally active and integrated into brain circuitryQ24523693
Chromosomal variation in neurons of the developing and adult mammalian nervous systemQ24555100
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
Defective DNA repair and neurodegenerative diseaseQ28250196
Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellumQ28508334
The Clinical Dementia Rating (CDR): current version and scoring rulesQ29616280
Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease.Q33497087
53BP1, a mediator of the DNA damage checkpointQ34153067
Positron emission tomographic studies of the cortical anatomy of single-word processingQ34171829
Aging of the human cerebellum: a stereological studyQ34269538
Gene regulation and DNA damage in the ageing human brainQ34326236
The cerebellar cognitive affective syndromeQ34467220
The aging brain: accumulation of DNA damage or neuron loss?Q34474172
The cerebellum and language: the story so far.Q34649719
Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseasesQ34775987
Cerebellum and nonmotor functionQ34988972
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's diseaseQ35816899
Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agentsQ36255573
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytesQ36979395
DNA strand breaks, neurodegeneration and aging in the brainQ37154126
Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.Q37187325
NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.Q37452311
Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.Q42439458
DNA replication precedes neuronal cell death in Alzheimer's disease.Q42502934
Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaningQ43598274
Microglia in cerebellar plaques in Alzheimer's diseaseQ44763168
Cell cycle activation linked to neuronal cell death initiated by DNA damageQ44774050
Assessing impulsivity changes in Alzheimer diseaseQ46506772
Cerebellar nuclei are involved in impulsive behaviour.Q47776332
Cerebellar involvement in progressive supranuclear palsy: A clinicopathological studyQ47889916
Aneuploidy and DNA replication in the normal human brain and Alzheimer's diseaseQ48124201
Cerebellar dentate nucleus in Alzheimer's disease with myoclonusQ48278137
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
Alzheimer's diseaseQ11081
P304page(s)60
P577publication date2010-12-20
P1433published inMolecular NeurodegenerationQ15817329
P1476titleDNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease
P478volume5

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cites work (P2860)
Q38368071A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death
Q39185516A disease with a sweet tooth: exploring the Warburg effect in Alzheimer's disease.
Q64076827Alzheimer's Disease and Cancer: When Two Monsters Cannot Be Together
Q35805267Assessment of copy number variations in the brain genome of schizophrenia patients.
Q34827354Cell cycle checkpoint abnormalities during dementia: A plausible association with the loss of protection against oxidative stress in Alzheimer's disease [corrected].
Q38192977Chronic functional bowel syndrome enhances gut-brain axis dysfunction, neuroinflammation, cognitive impairment, and vulnerability to dementia
Q47386934DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice.
Q33910490DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells
Q47719283DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's and dementia
Q64389910DNA-PK Deficiency in Alzheimer's Disease
Q33892330DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease?
Q36998015DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease
Q64052147Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease
Q48705096Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase
Q64235020Human chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density
Q37424545Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events
Q48880216Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia
Q48955789Neuroprotective effects of rosmarinic acid on ciguatoxin in primary human neurons.
Q38367422Oxidative Stress and Aberrant Cell Cycle in Alzheimer's Disease Lymphocytes: Diagnostic Prospects
Q38331188Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease
Q39332179Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead.
Q22252919Retinoids for treatment of Alzheimer's disease
Q36186434Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases.
Q37941287Stochastic modulations of the pace and patterns of ageing: impacts on quasi-stochastic distributions of multiple geriatric pathologies
Q26771812Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases
Q51763876The DNA replication stress hypothesis of Alzheimer's disease.

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