| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1011977412 |
| P356 | DOI | 10.1186/1471-2121-8-26 |
| P932 | PMC publication ID | 1919366 |
| P698 | PubMed publication ID | 17594478 |
| P5875 | ResearchGate publication ID | 6243946 |
| P50 | author | Zbyszek Darzynkiewicz | Q33103772 |
| Frank Traganos | Q77609899 | ||
| P2093 | author name string | Xuan Huang | |
| Toshiki Tanaka | |||
| Anthony P Albino | |||
| Diana Gietl | |||
| Ellen Jorgensen | |||
| P2860 | cites work | Oxidative Decay of DNA | Q22066181 |
| ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex | Q24298863 | ||
| Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer | Q24647338 | ||
| Megabase chromatin domains involved in DNA double-strand breaks in vivo | Q24680284 | ||
| DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 | Q28131715 | ||
| ATM phosphorylates histone H2AX in response to DNA double-strand breaks | Q28188651 | ||
| DNA repair activity for oxidative damage and risk of lung cancer | Q28204774 | ||
| The many substrates and functions of ATM | Q28205055 | ||
| DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation | Q28206029 | ||
| A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM | Q28270543 | ||
| Caffeine inhibits the checkpoint kinase ATM | Q28374785 | ||
| 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK). | Q30786843 | ||
| Induction of H2AX phosphorylation in pulmonary cells by tobacco smoke: a new assay for carcinogens | Q31094229 | ||
| Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis. | Q31141965 | ||
| Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats | Q32128541 | ||
| Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin | Q33200727 | ||
| Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis | Q33236024 | ||
| DNA adduct formation from tobacco-specific N-nitrosamines | Q33538109 | ||
| Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis | Q34334647 | ||
| ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity. | Q34471659 | ||
| Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants | Q34561662 | ||
| "ATR activation in response to ionizing radiation: still ATM territory". | Q34665992 | ||
| H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks | Q34772965 | ||
| The role of DNA breaks in genomic instability and tumorigenesis | Q35170919 | ||
| Acute effects of cigarette smoke on inflammation and oxidative stress: a review | Q35536904 | ||
| The potential contributions of chronic inflammation to lung carcinogenesis. | Q35575053 | ||
| Non-homologous DNA end joining. | Q35636648 | ||
| Initiating cellular stress responses | Q35830545 | ||
| Genotoxicity of environmental tobacco smoke: a review | Q35968072 | ||
| Genotoxicity of tobacco smoke and tobacco smoke condensate: a review | Q35968076 | ||
| Artemis links ATM to double strand break rejoining | Q36026384 | ||
| Making ends meet in old age: DSB repair and aging | Q36124249 | ||
| Different sensitivity of DNA in situ in interphase and metaphase chromatin to heat denaturation | Q36198558 | ||
| Dynamics of chromatin during the repair of DNA double-strand breaks. | Q36276737 | ||
| The ATM-dependent DNA damage signaling pathway | Q36547714 | ||
| Cohesin and DNA damage repair | Q36550391 | ||
| DNA damage-induced cell death by apoptosis. | Q36561337 | ||
| ATM activation and DNA damage response | Q36800838 | ||
| Laser scanning cytometry distinguishes lymphocytes, monocytes, and granulocytes by differences in their chromatin structure | Q36894155 | ||
| Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest | Q36959569 | ||
| Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species. | Q40259009 | ||
| Induction of DNA double-strand breaks in A549 and normal human pulmonary epithelial cells by cigarette smoke is mediated by free radicals. | Q40281788 | ||
| DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells | Q40299419 | ||
| DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner | Q40315391 | ||
| Phosphorylation of histone H2AX at M phase in human cells without DNA damage response | Q40375352 | ||
| Effects of pH on nicotine-induced DNA damage and oxidative stress | Q40389893 | ||
| ATM activation in normal human tissues and testicular cancer | Q40428814 | ||
| Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage | Q40494337 | ||
| Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors | Q40511617 | ||
| ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation | Q40570996 | ||
| UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress | Q40595912 | ||
| Genotoxicity and mutagenicity of chromium(VI)/ascorbate-generated DNA adducts in human and bacterial cells | Q40674862 | ||
| Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway | Q40916856 | ||
| Cell biology. Guiding ATM to broken DNA. | Q41912404 | ||
| Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes | Q42806461 | ||
| DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner | Q44078383 | ||
| Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody | Q44140576 | ||
| K-ras Gene Sequence Effects on the Formation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)−DNA Adducts | Q44409270 | ||
| Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. | Q44542313 | ||
| Detection of DNA damage in individual cells by analysis of histone H2AX phosphorylation | Q45189677 | ||
| Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis | Q46721068 | ||
| ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis | Q46903679 | ||
| Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis | Q46984194 | ||
| DNA-PK is responsible for enhanced phosphorylation of histone H2AX under hypertonic conditions. | Q51388672 | ||
| Cigarette tar promotes neutrophil-induced DNA damage in cultured lung cells. | Q53474322 | ||
| The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM. | Q53674709 | ||
| Cigarette smoke induces DNA single-strand breaks in human cells | Q59087600 | ||
| Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA BreaksIn vivo | Q62570682 | ||
| DNA Segments Sensitive to Single-Strand-Specific Nucleases Are Present in Chromatin of Mitotic Cells | Q62590560 | ||
| Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks | Q64388842 | ||
| The ATM-SMC1 pathway is essential for activation of the chromium[VI]-induced S-phase checkpoint | Q64388881 | ||
| Determination of DNA single-strand breaks in lymphocytes of smokers and nonsmokers exposed to environmental tobacco smoke using the nick translation assay | Q72639676 | ||
| The influence of antioxidants on cigarette smoke-induced DNA single-strand breaks in mouse organs: a preliminary study with the alkaline single cell gel electrophoresis assay | Q73622905 | ||
| Effects of tobacco smoke on the gene expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a subfamilies in mouse liver and lung: relation to single strand breaks of DNA | Q74214408 | ||
| P921 | main subject | phosphorylation | Q242736 |
| tobacco smoke | Q2386268 | ||
| P304 | page(s) | 26 | |
| P577 | publication date | 2007-06-26 | |
| P1433 | published in | BMC Cell Biology | Q2020930 |
| P1476 | title | ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke | |
| P478 | volume | 8 |
| Q40951607 | Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response |
| Q33948911 | Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry |
| Q33864110 | Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. |
| Q40012847 | Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage. |
| Q30317732 | Cellular senescence in normal and premature lung aging |
| Q35212021 | Characterisation of an aerosol exposure system to evaluate the genotoxicity of whole mainstream cigarette smoke using the in vitro γH2AX assay by high content screening |
| Q30845849 | Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells |
| Q33432971 | Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs). |
| Q33988971 | DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin |
| Q39713003 | DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes |
| Q28393323 | DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry |
| Q26822413 | DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis |
| Q34296170 | DNA damage signaling is activated during cancer progression in human colorectal carcinoma |
| Q36790428 | Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation |
| Q37260708 | Effects of side-stream tobacco smoke and smoke extract on glutathione- and oxidative DNA damage repair-deficient mice and blood cells |
| Q52720696 | Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema. |
| Q54979497 | In vitro assessment of the role of DpC in the treatment of head and neck squamous cell carcinoma. |
| Q33431359 | Induction of DNA damage response by the supravital probes of nucleic acids |
| Q37030899 | Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. |
| Q33799686 | Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. |
| Q33960475 | Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction |
| Q40567723 | SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue |
| Q34478300 | The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN). |
| Q37219336 | The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype |
| Q28392877 | gammaH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products |
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