Intracellular death platform steps-in: targeting prostate tumors via endoplasmic reticulum (ER) apoptosis

scientific article

Intracellular death platform steps-in: targeting prostate tumors via endoplasmic reticulum (ER) apoptosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1002/PROS.20828
P932PMC publication ID2740740
P698PubMed publication ID18663729
P5875ResearchGate publication ID23134323

P2093author name stringPerry A Christian
Steven R Schwarze
Natasha Kyprianou
Eric W Lin
Dustin T Gayheart
P2860cites workER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stressQ24291026
Caspase-10 is an initiator caspase in death receptor signalingQ24291922
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cellsQ24301679
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell deathQ24338605
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlQ24522941
Mendelian inheritance of familial prostate cancerQ24562051
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptorQ24597543
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.Q24815740
Cancer statistics, 2008Q27860585
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathwayQ27932953
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activationQ27936284
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsQ28117928
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
PERK mediates cell-cycle exit during the mammalian unfolded protein responseQ28141519
TRAIL receptor-2 signals apoptosis through FADD and caspase-8Q28142998
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8Q28189969
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).Q28240752
Intracellular signaling by the unfolded protein responseQ28250477
ASK1 is essential for JNK/SAPK activation by TRAF2Q28285612
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsQ28294137
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stressQ28306995
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient miceQ28359871
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and deathQ28363890
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cellsQ28513964
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hairQ28586758
bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestineQ28586868
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosisQ28588618
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopeniaQ28591736
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2Q28609079
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
The mammalian unfolded protein responseQ29547400
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleusQ29620179
A trip to the ER: coping with stressQ29620455
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosisQ29620466
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.Q30554728
Retrograde protein translocation: ERADication of secretory proteins in health and diseaseQ33676998
Tripartite management of unfolded proteins in the endoplasmic reticulumQ33941135
Organelle-specific initiation of cell death pathwaysQ34443559
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Retro-translocation of proteins from the endoplasmic reticulum into the cytosolQ34627241
Transcriptional and translational control in the Mammalian unfolded protein responseQ34762452
Targeting death and decoy receptors of the tumour-necrosis factor superfamilyQ34791120
ER-associated degradation in protein quality control and cellular regulationQ34970862
The CD95(APO-1/Fas) DISC and beyondQ35091401
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stressesQ35169632
Regulation of apoptosis by endoplasmic reticulum pathways.Q35591699
Coupling endoplasmic reticulum stress to the cell death programQ35649891
Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosisQ35922798
ER stress and the unfolded protein responseQ35986601
The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancerQ36015748
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).Q36561426
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein responseQ38614162
Stress-induced gene expression requires programmed recovery from translational repressionQ39735685
Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathwayQ40333039
Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosisQ40405415
Metastatic carcinoma of the prostate: identifying prognostic groups using recursive partitioningQ40616118
Apoptosis in prostate cancer. Molecular basis to study hormone refractory mechanismsQ40999465
Regulation of translational initiation during cellular responses to stressQ41600431
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.Q41747264
Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathwayQ42817119
The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient miceQ44489907
A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPasesQ48014886
Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.Q53512771
Ceramide-mediated clustering is required for CD95-DISC formationQ57369954
Endoplasmic reticulum-associated protein degradationQ60526595
Involvement of the bcl-2 gene in human follicular lymphomaQ69870224
Relationship of the structure and biological activity of the natural homologues of tunicamycinQ70288587
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancerQ80352321
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1Q81160686
P433issue15
P921main subjectendoplasmic reticulumQ79927
P304page(s)1615-1623
P577publication date2008-11-01
P1433published inThe ProstateQ7758608
P1476titleIntracellular death platform steps-in: targeting prostate tumors via endoplasmic reticulum (ER) apoptosis
P478volume68

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cites work (P2860)
Q38958946Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review
Q38953684Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo
Q35834796Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells
Q53510860Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants.
Q45128372Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium.
Q35974731Differential targeting of androgen and glucocorticoid receptors induces ER stress and apoptosis in prostate cancer cells: a novel therapeutic modality
Q47709017Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response.
Q91713061SPOP and cancer: a systematic review
Q28541919Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cells
Q38089963Targeting apoptosis by the remodelling of calcium-transporting proteins in cancerogenesis.
Q34509216The Polypeptide Binding Conformation of Calreticulin Facilitates Its Cell-surface Expression under Conditions of Endoplasmic Reticulum Stress

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