Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice

scientific article published on 30 December 2016

Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1194/JLR.M071266
P932PMC publication ID5335580
P698PubMed publication ID28039331

P2093author name stringXiaoying Liu
Richard M Green
Matthew J Schipma
Eric Zhang
Anne S Henkel
Brian E LeCuyer
Susan C Hubchak
P2860cites workFrom sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesisQ37596560
Fibroblast Growth Factor 19 and 7α-Hydroxy-4-Cholesten-3-one in the Diagnosis of Patients With Possible Bile Acid Diarrhea.Q42263341
Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.Q43759097
LXR alpha is the dominant regulator of CYP7A1 transcriptionQ44020852
Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat dietQ44119079
Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral bloodQ44300068
Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosisQ44626804
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injuryQ46823993
Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism.Q51387850
A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis.Q53648391
Bile acids: regulation of synthesisQ24658139
The enzymes, regulation, and genetics of bile acid synthesisQ28204726
Bile acid signaling in metabolic disease and drug therapyQ28244875
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alphaQ28273937
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the ratQ28577847
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).Q31943019
Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiencyQ34042571
Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitusQ34081372
Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiencyQ34245333
Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesisQ34467201
A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ miceQ34503382
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stressQ34801719
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
Endoplasmic reticulum stress in liver diseaseQ36031838
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar dietQ36382065
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activityQ36603679
Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liverQ37002627
Targeting bile-acid signalling for metabolic diseasesQ37231731
Unfolded protein response signaling and metabolic diseasesQ37488392
P4510describes a project that usesImageJQ1659584
P433issue3
P304page(s)504-511
P577publication date2016-12-30
P1433published inJournal of Lipid ResearchQ6295449
P1476titleHepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice
P478volume58

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cites work (P2860)
Q98193720A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Novel Drivers of Disease Progression in Primary Sclerosing Cholangitis
Q64965319Cholesterol metabolism-physiological regulation and pathophysiological deregulation by the endoplasmic reticulum.
Q47743188Deletion of endoplasmic reticulum stress-responsive co-chaperone p58IPK protects mice from diet-induced steatohepatitis.
Q97522970Endoplasmic reticulum stress and liver diseases

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