The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition

scientific article published on 21 September 2018

The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition is …
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scholarly articleQ13442814

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P356DOI10.3389/FENDO.2018.00539
P932PMC publication ID6161559
P698PubMed publication ID30298052

P50authorSoo Han BaeQ63610172
P2093author name stringSung Won Kwon
Dong-Kyu Lee
Byung-Wan Lee
Jeong Su Park
Da Hyun Lee
Yu Seol Lee
P2860cites workmTOR signaling in growth control and diseaseQ24634174
AKT/PKB signaling: navigating downstreamQ24657857
The Natural Course of Non-Alcoholic Fatty Liver DiseaseQ26746947
Transcriptional regulation of hepatic lipogenesisQ26778594
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damageQ28117084
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathwaysQ28242180
Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1cQ28297047
Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometryQ28395402
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stressQ28511471
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liverQ28583240
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Activation of a metabolic gene regulatory network downstream of mTOR complex 1Q29615179
Molecular mediators of hepatic steatosis and liver injuryQ29616709
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological AssociationQ29617157
mTOR signaling at a glanceQ29619857
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayQ30425628
Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New TreatmentsQ33616887
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.Q33734395
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesisQ33734679
Non-alcoholic fatty liver disease: An expanded reviewQ33789868
Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).Q34139142
Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes.Q34315432
Herbal formulation, DIA-2 and Rosiglitazone ameliorates hyperglycemia and hepatic steatosis in type 2 diabetic rats.Q50561554
Carcinogenicity study of CKD-501, a novel dual peroxisome proliferator-activated receptors α and γ agonist, following oral administration to Sprague Dawley rats for 94-101 weeks.Q53056780
Safety and efficacy of lobeglitazone monotherapy in patients with type 2 diabetes mellitus over 52 weeks: An open-label extension study.Q53191415
Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt.Q55030805
Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice.Q55691519
Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockoutsQ61575260
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistanceQ74453774
Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvementQ79825065
Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinomaQ81329832
Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidationQ34512108
Quantification of CKD-501, lobeglitazone, in rat plasma using a liquid-chromatography/tandem mass spectrometry method and its applications to pharmacokinetic studiesQ34990638
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinaseQ36342908
De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucoseQ36800168
Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trialQ36972810
Rosiglitazone is associated with mortality in chronic hemodialysis patients.Q37181975
Lobeglitazone and pioglitazone as add-ons to metformin for patients with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, parallel-group, active-controlled, phase III clinical trial with a 28-week extensionQ37257466
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD).Q37281827
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.Q37388544
Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to ResponsivenessQ37482466
As a matter of fat.Q37543677
In vivo actions of peroxisome proliferator-activated receptors: glycemic control, insulin sensitivity, and insulin secretionQ37577126
Clinical approaches to non-alcoholic fatty liver diseaseQ37596187
Thiazolidinediones and PPARγ agonists: time for a reassessmentQ38003533
New insights into ER stress-induced insulin resistance.Q38024445
A Central role for mTOR in lipid homeostasisQ38131225
PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.Q38332175
Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpressionQ38361574
CKD-501, a novel selective PPARγ agonist, shows no carcinogenic potential in ICR mice following oral administration for 104 weeksQ38446975
Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategiesQ38705659
Endoplasmic reticulum proteostasis in hepatic steatosis.Q38925531
Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis.Q39097575
Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat modelQ39165020
Role of peroxisome proliferator-activated receptor gamma agonist in improving hepatic steatosis: Possible molecular mechanismQ39604886
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
A futile metabolic cycle activated in adipocytes by antidiabetic agentsQ40700524
Mammalian mitochondrial beta-oxidationQ41280085
Update on pparγ and nonalcoholic Fatty liver diseaseQ41903480
Preparation of fatty acid methyl esters for gas-liquid chromatographyQ42062849
Isolation and primary culture of rat hepatic cellsQ42175713
A pilot study of pioglitazone treatment for nonalcoholic steatohepatitisQ44749300
Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomicsQ44819530
Pioglitazone and risk of bladder cancer: clarification of the design of the French study. Reply to Perez AT [letter].Q46868396
Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugsQ47169300
Current and future pharmacological therapies for NAFLD/NASH.Q47778507
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectsirolimusQ32089
P304page(s)539
P577publication date2018-09-21
P1433published inFrontiers in EndocrinologyQ27723680
P1476titleThe Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition
P478volume9

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