Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation

scientific article published on 5 February 2016

Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP20405
P932PMC publication ID4742779
P698PubMed publication ID26846206
P5875ResearchGate publication ID293192214

P50authorJean-Pierre MontaniQ80061669
P2093author name stringChang Liu
Zhihong Yang
Xiu-Fen Ming
Erwin Riedo
Angana G Rajapakse
Benoit Fellay
Marie-Claire Bernhard
P2860cites workInhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitisQ53555710
Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytesQ74346826
Role of AMP-activated protein kinase in mechanism of metformin actionQ22241898
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthQ24309283
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell lineQ24317499
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant miceQ28591122
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityQ29614241
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismQ29617261
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromeQ29619211
Nonalcoholic fatty liver diseaseQ29619354
Macrophage plasticity in experimental atherosclerosisQ33527405
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistanceQ33604466
Inflammatory mediators of hepatic steatosis.Q33734136
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesisQ33734679
C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosisQ33750735
Genealogies of mouse inbred strainsQ33806120
Genetic control of de novo lipogenesis: role in diet-induced obesityQ33867059
Arginase inhibition ameliorates hepatic metabolic abnormalities in obese miceQ33946024
Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disordersQ34406933
Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in miceQ34761076
Mechanism of AMPK Suppression of LXR-dependent Srebp-1c TranscriptionQ35022533
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosisQ35852802
Hyperargininemia due to liver arginase deficiencyQ36031833
Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and AtherogenesisQ36366280
Isolation of human liver arginase cDNA and demonstration of nonhomology between the two human arginase genesQ36481975
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animalsQ37072370
Selective versus total insulin resistance: a pathogenic paradoxQ37076798
Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanismQ37198831
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.Q37278531
Molecular mechanisms and therapeutic targets in steatosis and steatohepatitisQ37299002
Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque VulnerabilityQ37310506
LKB1 and AMP-activated protein kinase control of mTOR signalling and growthQ37383513
Adiponectin: a key adipokine in alcoholic fatty liverQ37505809
Clinical Review: Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications.Q38072021
A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouseQ38333946
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II geneQ39457714
Glucose-6-phosphate dehydrogenase regulation in the hepatopancreas of the anoxia-tolerant marine mollusc, Littorina littoreaQ39901540
Mulberry Anthocyanins Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipogenesis and Promotion of Hepatic Lipid ClearanceQ40245640
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.Q40480010
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cellsQ40515180
Positive crosstalk between arginase‐II and S6K1 in vascular endothelial inflammation and agingQ41412735
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.Q41644055
Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesisQ42111412
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturaseQ42563412
Characterization of distinct subpopulations of hepatic macrophages in HFD/obese miceQ42688383
Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O.Q42818414
Insulin and the regulation of adipose tissue acetyl-coenzyme A carboxylaseQ42923515
Obesity Notches up fatty liverQ44037277
Widespread expression of arginase I in mouse tissues. Biochemical and physiological implicationsQ44552211
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient miceQ47222234
Immunohistochemical study of arginase 1 and 2 in various tissues of rats.Q48860026
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
steatosisQ1365091
P304page(s)20405
P577publication date2016-02-05
P1433published inScientific ReportsQ2261792
P1476titleTargeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation
P478volume6

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cites work (P2860)
Q51767790Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis
Q64229200Critical role for arginase II in osteoarthritis pathogenesis
Q51735384Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice
Q61806633Depletion of B cell-activating factor attenuates hepatic fat accumulation in a murine model of nonalcoholic fatty liver disease
Q48354848Dietary and metabolic modulators of hepatic immunity
Q47217999Disruption of Adenosine 2A Receptor Exacerbates NAFLD through Increasing Inflammatory Responses and SREBP1c Activity
Q37428427Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity
Q100694438HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse
Q64067708Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
Q67876060L-Norvaline, a new therapeutic agent against Alzheimer's disease
Q92538708Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack
Q92195093Mechanisms of obesity-induced metabolic and vascular dysfunctions
Q92921921Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity
Q64062113Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice
Q92012498Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice
Q49949624Short-term treatment with metformin reduces hepatic lipid accumulation but induces liver inflammation in obese mice
Q64912987Systems analysis reveals complex biological processes during virus infection fate decisions.

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