Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis

scientific article published on 22 February 2018

Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-018-0356-9
P953full work available online athttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833809
P932PMC publication ID5833809
P698PubMed publication ID29472548

P50authorJean-Pierre MontaniQ80061669
P2093author name stringYi Yu
Zhihong Yang
Xiu-Fen Ming
Yuyan Xiong
P2860cites workRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acidsQ24306330
Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell lineQ24317499
Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomesQ24338154
Sex-specific regulation of gene expression in the aging monkey aortaQ80211278
mTOR signaling in growth control and diseaseQ24634174
Chromosomal localization of the human arginase II gene and tissue distribution of its mRNAQ28116636
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosomeQ28307704
Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged miceQ28390561
Localization of myosin 1b to actin protrusions requires phosphoinositide bindingQ28566730
A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cellsQ28854295
Roles of conserved residues in the arginase familyQ30429868
Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomesQ30498164
Leveraging the membrane - cytoskeleton interface with myosin-1.Q33965456
Ras transformation uncouples the kinesin-coordinated cellular nutrient responseQ33972110
Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by ResveratrolQ34841910
Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesisQ35484919
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosisQ35852802
Endothelial arginase: a new target in atherosclerosisQ36442590
Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammationQ36548517
Association of myosin I alpha with endosomes and lysosomes in mammalian cellsQ36864538
Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque VulnerabilityQ37310506
Lysosomal recruitment of TSC2 is a universal response to cellular stressQ38463291
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.Q38788245
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II geneQ39457714
Positive crosstalk between arginase‐II and S6K1 in vascular endothelial inflammation and agingQ41412735
KIF2beta , a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocationQ41835503
Lysosomal positioning coordinates cellular nutrient responses.Q42160015
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.Q43170208
Endothelial arginase II: a novel target for the treatment of atherosclerosisQ46726767
Arginase-II Promotes Tumor Necrosis Factor-α Release From Pancreatic Acinar Cells Causing β-Cell Apoptosis in AgingQ47811287
Immunohistochemical study of arginase 1 and 2 in various tissues of rats.Q48860026
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P921main subjectcellular senescenceQ9075999
P304page(s)313
P577publication date2018-02-22
P1433published inCell Death and DiseaseQ2197222
P1476titleArginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis
P478volume9

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cites work (P2860)
Q89865890Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration
Q92207064Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus

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