ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis

scientific article published in January 2014

ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/15548627.2014.981789
P932PMC publication ID4502672
P698PubMed publication ID25484082

P50authorJean-Pierre MontaniQ80061669
P2093author name stringYi Yu
Zhihong Yang
Xiu-Fen Ming
Yuyan Xiong
Gautham Yepuri
Michael Forbiteh
P2860cites workStable overexpression of arginase I and ornithine transcarbamylase in HepG2 cells improves its ammonia detoxificationQ39469915
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagyQ39739155
Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytesQ40249077
Bafilomycin A1 Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomes and Lysosomes in Rat Hepatoma Cell Line, H-4-II-E CellsQ41031244
Positive crosstalk between arginase‐II and S6K1 in vascular endothelial inflammation and agingQ41412735
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylationQ41792404
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.Q51057544
Autophagy in Human Health and DiseaseQ61649478
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cellsQ67902824
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytesQ73067976
Translational evidence that impaired autophagy contributes to arterial ageingQ84092191
Guidelines for the use and interpretation of assays for monitoring autophagyQ21996341
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunctionQ24292963
mTOR signaling in growth control and diseaseQ24634174
Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvalineQ24647607
Regulation of autophagy by cytoplasmic p53Q24651258
Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagyQ27675343
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1Q28115279
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Q28506431
Regulation mechanisms and signaling pathways of autophagyQ29547416
Induction of autophagy by spermidine promotes longevityQ29614498
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagyQ29615616
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytesQ29617843
Autophagy in human health and diseaseQ29620121
Amino acid signalling upstream of mTORQ34325138
Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cellsQ34443037
Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by ResveratrolQ34841910
Complex inhibitory effects of nitric oxide on autophagyQ35145954
Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Death via Inhibition of p70 S6 Kinase 1-Mediated AutophagyQ35847671
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiaeQ36017028
Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and AtherogenesisQ36366280
Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytesQ36388407
Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and InflammationQ36920831
Polyamine depletion inhibits the autophagic response modulatingTrypanosoma cruziinfectivityQ37043029
Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque VulnerabilityQ37310506
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.Q37476530
Macroautophagy signaling and regulationQ37608022
Physiological significance of selective degradation of p62 by autophagyQ37691820
Regulation of mammalian autophagy in physiology and pathophysiology.Q37801517
The regulation of autophagy – unanswered questionsQ37824183
Autophagy in atherosclerosis: a potential drug target for plaque stabilizationQ37957842
mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseasesQ38056232
Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systemsQ38094885
Regulation of autophagy by stress-responsive transcription factorsQ38111103
Emerging regulation and functions of autophagyQ38118567
P433issue12
P921main subjectendotheliumQ111140
autophagyQ288322
atherosclerosisQ12252367
P304page(s)2223-2238
P577publication date2014-01-01
P1433published inAutophagyQ1255295
P1476titleARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
P478volume10

Reverse relations

cites work (P2860)
Q64117174/miR-15b-5p/ mediates endothelial progenitor cells autophagy and affects coronary atherosclerotic heart disease via mTOR signaling pathway
Q37649641Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases
Q88653723Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity
Q48259722Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition.
Q36268285Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling
Q41699705Arginase-II Deficiency Extends Lifespan in Mice
Q51767790Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis
Q39033964Arginine Metabolism Revisited.
Q35585683Autophagy induction by silibinin positively contributes to its anti-metastatic capacity via AMPK/mTOR pathway in renal cell carcinoma
Q61798742Clinical Experience of Sirolimus Regarding Efficacy and Safety in Systemic Lupus Erythematosus
Q64229200Critical role for arginase II in osteoarthritis pathogenesis
Q52589085Dynamic transcriptomic analysis of Ischemic Injury in a Porcine Pre-Clinical Model mimicking Donors Deceased after Circulatory Death
Q49407554Effect and molecular mechanism of mTOR inhibitor rapamycin on temozolomide-induced autophagic death of U251 glioma cells
Q28548356G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma
Q37428427Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity
Q64067708Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
Q58585928Inhibitory Effects of Ginsenoside Rb1 on Early Atherosclerosis in ApoE-/- Mice via Inhibition of Apoptosis and Enhancing Autophagy
Q97419830LACTB Regulates PIK3R3 to Promote Autophagy and Inhibit EMT and Proliferation Through the PI3K/AKT/mTOR Signaling Pathway in Colorectal Cancer
Q53302687Low Shear Stress Inhibited Endothelial Cell Autophagy Through TET2 Downregulation
Q64092526Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells
Q92431192Lycium barbarum polysaccharide induced apoptosis and inhibited proliferation in infantile hemangioma endothelial cells via down-regulation of PI3K/AKT signaling pathway
Q89883298Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis
Q36879619MiR-129-5p-mediated Beclin-1 suppression inhibits endothelial cell autophagy in atherosclerosis
Q38778675MiR-144 inhibits cell proliferation of renal cell carcinoma by targeting MTOR.
Q38674286MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2.
Q90686994Microparticles and autophagy: a new frontier in the understanding of atherosclerosis in rheumatoid arthritis
Q38753559Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement
Q33799132Oestrogen Inhibits Arterial Calcification by Promoting Autophagy
Q39381435Perpetual change: autophagy, the endothelium, and response to vascular injury
Q90291199Quercetin has a protective effect on atherosclerosis via enhancement of autophagy in ApoE-/- mice
Q46106014Salen-Mn compounds induces cell apoptosis in human prostate cancer cells through promoting AMPK activity and cell autophagy
Q36548517Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation
Q37718232Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice
Q57281862The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target
Q92861810Transcriptome Profiling of Bovine Macrophages Infected by Mycobacterium avium spp. paratuberculosis Depicts Foam Cell and Innate Immune Tolerance Phenotypes
Q90308406VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1
Q89508085mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway
Q33809004miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells.

Search more.