Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity

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Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2016.00560
P932PMC publication ID5118905
P698PubMed publication ID27920727

P50authorJean-Pierre MontaniQ80061669
P2093author name stringJi Huang
Zhihong Yang
François Verrey
Xiu-Fen Ming
Yuyan Xiong
Angana Rajapakse
P2860cites workWorldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participantsQ37368135
Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide productionQ37395034
l-Citrulline Protects from Kidney Damage in Type 1 Diabetic MiceQ37412089
Endothelial dysfunction as a potential contributor in diabetic nephropathyQ37806614
Uncoupling of endothelial NO synthase in atherosclerosis and vascular diseaseQ38080267
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II geneQ39457714
Positive crosstalk between arginase‐II and S6K1 in vascular endothelial inflammation and agingQ41412735
Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db miceQ42266127
Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O.Q42818414
Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interactionQ44779281
Structural and functional changes in the kidneys of high-fat diet-induced obese miceQ46275989
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.Q46884682
Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide productionQ46956733
The kidney in diabetes: dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007.Q48552318
Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic ratsQ74102336
Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat dietQ81251021
Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stressQ83862226
Arginase deficiency with new phenotype and a novel mutation: contemporary summaryQ84957633
Renal endothelial dysfunction in diabetic nephropathyQ27021318
Chromosomal localization of the human arginase II gene and tissue distribution of its mRNAQ28116636
Nitric oxide synthases: regulation and functionQ28247092
Oxidant Mechanisms in Renal Injury and DiseaseQ28384392
Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox BalanceQ28385322
Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculusQ28504781
Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathwayQ28509217
US Renal Data System 2012 Annual Data ReportQ30582337
Workshop: endothelial cell dysfunction leading to diabetic nephropathy : focus on nitric oxideQ32072936
Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disordersQ34406933
A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathyQ34549867
Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementationQ34627559
Myeloperoxidase produces nitrating oxidants in vivoQ34791672
Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by ResveratrolQ34841910
Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic functionQ34973749
Role of p38 mitogen-activated protein kinase in vascular endothelial aging: interaction with Arginase-II and S6K1 signaling pathwayQ35149545
The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23.Q35198655
AMPK mediates the initiation of kidney disease induced by a high-fat dietQ35272259
Arginase-2 Mediates Diabetic Renal InjuryQ35405005
p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-uncoupling in obesityQ35576389
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosisQ35852802
Structure and function of arginasesQ35909707
Hyperargininemia due to liver arginase deficiencyQ36031833
Pathogenic role of nitric oxide alterations in diabetic nephropathyQ36326387
Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and AtherogenesisQ36366280
Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammationQ36548517
Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and InflammationQ36920831
Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesityQ37142625
Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanismQ37198831
Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque VulnerabilityQ37310506
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
inflammationQ101991
P304page(s)560
P577publication date2016-11-22
P1433published inFrontiers in PhysiologyQ2434141
P1476titleGenetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity
P478volume7

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cites work (P2860)
Q41699705Arginase-II Deficiency Extends Lifespan in Mice
Q52714758Arginase-II negatively regulates renal aquaporin-2 and water reabsorption.
Q92195093Mechanisms of obesity-induced metabolic and vascular dysfunctions

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