The oxysterol 24(s),25-epoxycholesterol attenuates human smooth muscle-derived foam cell formation via reduced low-density lipoprotein uptake and enhanced cholesterol efflux

scientific article published on 22 June 2012

The oxysterol 24(s),25-epoxycholesterol attenuates human smooth muscle-derived foam cell formation via reduced low-density lipoprotein uptake and enhanced cholesterol efflux is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/JAHA.112.000810
P932PMC publication ID3487330
P698PubMed publication ID23130136
P5875ResearchGate publication ID232923193

P50authorRobert A. HegeleQ58046422
Murray W HuffQ87799101
P2093author name stringCynthia G Sawyez
Jane Y Edwards
Caroline O'Neil
J Geoffrey Pickering
Michael M Beyea
Samantha Reaume
P2860cites workHepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1cQ24300790
Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterolQ24337975
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptorQ24656186
Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemiaQ24657127
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesQ24683425
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to InsigQ24683936
Molecular biology of PCSK9: its role in LDL metabolismQ27488922
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptorsQ28215527
Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clearQ28255975
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol depositionQ28625661
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Protein sensors for membrane sterolsQ29617313
Role of smooth muscle cells in the initiation and early progression of atherosclerosisQ30438867
Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularizationQ33895700
Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesionsQ34143741
Identification of macrophage liver X receptors as inhibitors of atherosclerosisQ34154665
Class A scavenger receptors, macrophages, and atherosclerosisQ34372269
Liver X Receptor Signaling Pathways in Cardiovascular DiseaseQ35104848
The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterolsQ38296407
ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells.Q39837617
Lipid incorporation inhibits Src-dependent assembly of fibronectin and type I collagen by vascular smooth muscle cellsQ39881932
Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.Q40070884
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosisQ40142846
Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.Q40241827
Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptorQ40528839
Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formationQ40631077
Promoter analysis of the mouse sterol regulatory element-binding protein-1c geneQ40864894
Uptake of type III hypertriglyceridemic VLDL by macrophages is enhanced by oxidation, especially after remnant formationQ41084454
Cholesterol accumulation in J774 macrophages induced by triglyceride-rich lipoproteins. Comparison of very low density lipoprotein from subjects with type III, IV, and V hyperlipoproteinemias.Q41692355
Innate diversity of adult human arterial smooth muscle cells: cloning of distinct subtypes from the internal thoracic arteryQ43738115
Modified low density lipoprotein isolated from atherosclerotic lesions does not cause lipid accumulation in aortic smooth muscle cellsQ44431948
Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteriesQ44940978
Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cellsQ45153424
LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.Q46344510
Further characterization of the acetyl LDL (scavenger) receptor expressed by rabbit smooth muscle cells and fibroblastsQ46845480
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivoQ46859453
Human smooth muscle cell subpopulations differentially accumulate cholesteryl ester when exposed to native and oxidized lipoproteinsQ47638028
Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes.Q52831306
P433issue3
P921main subject24(S), 25-epoxycholesterolQ27071872
P304page(s)e000810
P577publication date2012-06-22
P1433published inJournal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseQ19880670
P1476titleThe oxysterol 24(s),25-epoxycholesterol attenuates human smooth muscle-derived foam cell formation via reduced low-density lipoprotein uptake and enhanced cholesterol efflux
P478volume1

Reverse relations

cites work (P2860)
Q38098775A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
Q34013439ABCC6- a new player in cellular cholesterol and lipoprotein metabolism?
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Q33825128PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
Q38852365Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis
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Q49551883Smooth Muscle Cell Fate and Plasticity in Atherosclerosis