Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue

scientific article published on June 2013

Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/OBY.20134
P932PMC publication ID3740458
P698PubMed publication ID23913732
P5875ResearchGate publication ID255178630

P2093author name stringPeter Cheung
Guenther Boden
Carol Homko
Catherine Loveland-Jones
Sajad Salehi
Senthil Jayarajan
Weiwei Song
P2860cites workER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ERQ24305459
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteinsQ24307390
Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesisQ24554492
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cellsQ24561820
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesisQ24631468
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1Q28276509
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complexQ33553700
Acute tissue injury caused by subcutaneous fat biopsies produces endoplasmic reticulum stressQ33586789
Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal ratsQ33782820
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genesQ33878155
Human fatty liver disease: old questions and new insightsQ35588477
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetesQ36698641
ChREBP, a transcriptional regulator of glucose and lipid metabolismQ36788526
SREBPs: the crossroads of physiological and pathological lipid homeostasisQ37091373
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Insulin-induced gene: a new regulator in lipid metabolismQ37785307
Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesityQ38468823
Synthesis of fatty acids and cholesterol by liver, adipose tissue and intestinal mucosa from obese and control patientsQ39704294
Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1).Q40142837
Regulation of lipogenic enzyme expression by glucose in liver and adipose tissue: a review of the potential cellular and molecular mechanismsQ41163883
Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.Q42997321
Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humansQ44300043
Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding modelQ46243875
Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liverQ46818626
Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP.Q53621919
Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phosphoenolpyruvate carboxykinase (GTP) gene transcriptionQ64379685
Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissueQ73746144
Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liverQ83810163
Comparative aspects of lipogenesis in mammalian tissuesQ93814281
P433issue6
P921main subjectpreproinsulinQ7240673
P304page(s)1208-1214
P577publication date2013-06-01
P1433published inObesityQ15763232
P1476titleComparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue
P478volume21

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cites work (P2860)
Q64096895A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices
Q55231905Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice.
Q26801099Fructose Metabolism and Relation to Atherosclerosis, Type 2 Diabetes, and Obesity
Q38983004Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216.
Q46355687Human Protein Kinases and Obesity
Q64091126Insulin Controls Triacylglycerol Synthesis through Control of Glycerol Metabolism and Despite Increased Lipogenesis
Q36329899The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
Q48364108The retinol-binding protein receptor STRA6 regulates diurnal insulin responses.
Q64377093miR-122 Regulates LHR Expression in Rat Granulosa Cells by Targeting Insig1 mRNA

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