Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity

scientific article

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DB12-1748
P932PMC publication ID3806615
P698PubMed publication ID23919961
P5875ResearchGate publication ID255692881

P50authorHubert VidalQ33112025
Etienne LefaiQ37382840
Jaswinder K. SethiQ54165884
Antonio Vidal-PuigQ61080073
Christopher J. LelliottQ67390424
Matej OrešičQ38591100
José Manuel Fernández-RealQ41484123
Dominique LanginQ41580270
Miguel LópezQ47360047
P2093author name stringFrancisco J Tinahones
Tingting Wu
Mohammad Bohlooly-Y
Julian L Griffin
Martine Laville
Antoinette Tuthill
Nuria Barbarroja
Gema Medina-Gomez
Marc Slawik
Sam Virtue
Robert V Considine
Helen J Atherton
Audrey Sicard
Mikael Bjursell
Rachel M Hagen
Stefania Carobbio
Chong-Yew Tan
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Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesisQ24554492
Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytesQ24681212
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob miceQ28144106
SREBP transcription factors: master regulators of lipid homeostasisQ28297603
Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling networkQ28510784
Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteinsQ28585597
Identification of mouse palmitoyl-coenzyme A Delta9-desaturaseQ28594625
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Protein sensors for membrane sterolsQ29617313
Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissuesQ31957956
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolismQ33283063
Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genesQ33354965
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humansQ33930538
Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in DrosophilaQ34497344
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese miceQ34615417
The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitroQ35004507
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesityQ35820541
Obesity-associated improvements in metabolic profile through expansion of adipose tissueQ35945161
Development and validation of a robust automated analysis of plasma phospholipid fatty acids for metabolic phenotyping of large epidemiological studiesQ36997973
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cellsQ37364195
The clinical investigator: bewitched, bothered, and bewildered--but still belovedQ37368412
Metabolic phenotyping of a model of adipocyte differentiationQ37394769
Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation.Q51370984
Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.Q51450080
Depot-specific differences in adipose tissue gene expression in lean and obese subjectsQ74013169
Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liverQ77696898
Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy menQ85831190
Allostatic load biomarkers of chronic stress and impact on health and cognitionQ37613168
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspectiveQ37670371
Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C targetQ38288603
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.Q38288889
Leptin regulates peripheral lipid metabolism primarily through central effects on food intakeQ38289205
CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive geneQ38298235
Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesisQ38342643
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoansQ39451299
Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.Q41120977
Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms.Q42008267
Sterol regulatory element binding protein 1c (SREBP-1c) expression in human obesityQ43798644
Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alphaQ43935429
Sterol regulatory element binding proteins: relationship of adipose tissue gene expression with obesity in humansQ44000276
Insulin resistance in the control of body fat distribution: a new hypothesisQ46223588
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndromeQ46458713
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptakeQ46884435
Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.Q46888113
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
P304page(s)3697-3708
P577publication date2013-08-06
P1433published inDiabetesQ895262
P1476titleAdaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity
P478volume62

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