Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes

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Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2003PNAS..100.9476L
P356DOI10.1073/PNAS.1133426100
P8608Fatcat IDrelease_iplzsxvvxzan7e2jgz4jxu66yu
P932PMC publication ID170943
P698PubMed publication ID12869692
P5875ResearchGate publication ID10654206

P2093author name stringKiyosumi Takaishi
William Cook
Jinping Li
Roger H Unger
Sara Kay McCorkle
P2860cites workCrucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ERQ24305459
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteinsQ24307390
Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 geneQ24324902
Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiationQ28269495
Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating proteinQ28295187
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liverQ28583240
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposityQ33960868
Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storageQ34731483
ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiationQ36694542
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetesQ36698641
Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesityQ38468823
Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptakeQ41752486
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
Insulin induced gene 1Q21498638
P304page(s)9476-81
P577publication date2003-08-05
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleInsig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes
P478volume100

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cites work (P2860)
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