Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

scientific article published on 16 May 2016

Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/APS.2016.21
P932PMC publication ID4973377
P698PubMed publication ID27180982

P2093author name stringPing Zhan
Zhi-Wen Yu
Li-Wei Ren
Zi-Yu Zhou
Dan-Dan Chai
Han-Yan Yang
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Dietary Lycium barbarum polysaccharide induces Nrf2/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K/AKT signaling.Q33871538
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy stateQ33968008
Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction.Q34044814
Effect of metformin on metabolic improvement and gut microbiotaQ34261321
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An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese miceQ34785134
Intestinal microbiota and faecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitusQ35094314
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy statusQ35534198
Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed miceQ35988139
Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanismQ36071738
Influence of gut microbiota on subclinical inflammation and insulin resistanceQ36960218
Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide.Q37051853
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.Q37503122
Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemiaQ38020262
Role of the gut microbiota in human nutrition and metabolism.Q38164063
Understanding and modulating the Toll like Receptors (TLRs) and NOD like Receptors (NLRs) cross talk in type 2 diabetes.Q38211752
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Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivoQ39602218
Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells.Q39704421
Interaction of insulin with prokinetic drugs in STZ-induced diabetic miceQ40400795
Pathophysiology of insulin resistance in human disease.Q40453488
Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat.Q41163942
Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice.Q42002525
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-ImidazolideQ42155559
Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent mannerQ42518946
Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cellsQ42716268
Lipopolysaccharides reduce adipogenesis in 3T3-L1 adipocytes through activation of NF-κB pathway and downregulation of AMPK expressionQ42819277
Expression of PTEN and Akt phosphorylation in lipopolysaccharide-treated NIH3T3 cells.Q42834017
Improved extraction of PCR-quality community DNA from digesta and fecal samplesQ44902635
ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injuryQ46149189
Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia.Q48451001
Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice.Q51353616
Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.Q54397165
P433issue8
P921main subjectmetforminQ19484
glucoseQ37525
endotoxemiaQ5832599
preproinsulinQ7240673
P304page(s)1063-1075
P577publication date2016-05-16
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleMetformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling
P478volume37

Reverse relations

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