| scholarly article | Q13442814 |
| retracted paper | Q45182324 |
| P356 | DOI | 10.1161/CIRCULATIONAHA.107.716498 |
| P698 | PubMed publication ID | 17875968 |
| P50 | author | Ping Song | Q42412321 |
| P2093 | author name string | Jian Xu | |
| Miao Zhang | |||
| Yong Wu | |||
| Zhonglin Xie | |||
| Ming-Hui Zou | |||
| Yunzhou Dong | |||
| P2860 | cites work | Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. | Q42523433 |
| Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation | Q43833571 | ||
| High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endotheli | Q43833580 | ||
| Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite. | Q44489729 | ||
| Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats | Q46570586 | ||
| Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis | Q46740172 | ||
| Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. | Q46890287 | ||
| Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite | Q50336019 | ||
| Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model | Q71197849 | ||
| Peroxynitrite-mediated oxidation of dihydrorhodamine 123 | Q71999696 | ||
| Myocardial cell death in human diabetes | Q73281473 | ||
| High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells | Q73542912 | ||
| Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase | Q80011865 | ||
| Phosphorylation of the PTEN tail regulates protein stability and function | Q22254305 | ||
| The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation | Q24290417 | ||
| 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase | Q24336639 | ||
| Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3 | Q24672153 | ||
| Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation | Q24682735 | ||
| Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | Q27620298 | ||
| Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group | Q27860882 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action | Q28199220 | ||
| Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis | Q28300857 | ||
| Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site | Q28363492 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Reversible inactivation of the tumor suppressor PTEN by H2O2 | Q29615204 | ||
| Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage | Q29616101 | ||
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
| Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue | Q33707592 | ||
| Muscle-specific Pten deletion protects against insulin resistance and diabetes | Q33714209 | ||
| LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes | Q34558919 | ||
| Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane | Q34574432 | ||
| Membrane-binding and activation mechanism of PTEN. | Q35145882 | ||
| Nitric oxide release accounts for insulin's vascular effects in humans | Q35824740 | ||
| Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus. | Q35888585 | ||
| Redox regulation of PI 3-kinase signalling via inactivation of PTEN | Q36266420 | ||
| Enhanced peroxynitrite formation is associated with vascular aging | Q36404553 | ||
| Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected] | Q36604703 | ||
| Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells | Q36636052 | ||
| Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus | Q37239783 | ||
| Nitric oxide, oxidants, and protein tyrosine nitration | Q37356224 | ||
| Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice | Q38290824 | ||
| Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite | Q39737681 | ||
| Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endotheli | Q40328533 | ||
| Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. | Q40460391 | ||
| The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes | Q40884595 | ||
| Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation | Q42497877 | ||
| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | hyperglycemia | Q271993 |
| apoptotic process | Q14599311 | ||
| P304 | page(s) | 1585-1595 | |
| P577 | publication date | 2007-09-17 | |
| P1433 | published in | Circulation | Q578091 |
| P1476 | title | Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner | |
| P478 | volume | 116 |
| Q38131559 | A critical and comprehensive insight on heme oxygenase and related products including carbon monoxide, bilirubin, biliverdin and ferritin in type-1 and type-2 diabetes |
| Q57471017 | A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation through restoration of autophagy flux |
| Q37752670 | A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS. |
| Q34614152 | AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts |
| Q37619809 | AMPKα1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. |
| Q35606335 | AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells |
| Q36483970 | Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts |
| Q37295345 | Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein |
| Q37542673 | Adenosine monophosphate-activated protein kinase-α2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation |
| Q41763265 | Altered SDF-1-mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus. |
| Q51758983 | Amino acids potentiate insulin signaling in CHO-K1 at high glucose conditions. |
| Q47372589 | Apoptosis occurs differentially according to glomerular size in diabetic kidney disease |
| Q36523311 | Application of percutaneous balloon mitral valvuloplasty in patients of rheumatic heart disease mitral stenosis combined with tricuspid regurgitation |
| Q36480012 | Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration |
| Q54243194 | Beneficial effect of zinc chloride and zinc ionophore pyrithione on attenuated cardioprotective potential of preconditioning phenomenon in STZ-induced diabetic rat heart. |
| Q43147039 | Cardiac protection by basic fibroblast growth factor from ischemia/reperfusion-induced injury in diabetic rats |
| Q38134022 | Cellular and molecular mechanisms of endothelial dysfunction in diabetes |
| Q24658069 | Chemistry and antihypertensive effects of tempol and other nitroxides |
| Q55008130 | Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways? |
| Q51026386 | Dickkopf-1 (DKK1) phosphatase and tensin homolog on chromosome 10 (PTEN) crosstalk via microRNA interference in the diabetic heart. |
| Q36043779 | Differences in myocardial PTEN expression and Akt signalling in type 2 diabetic and nondiabetic patients undergoing coronary bypass surgery |
| Q85992719 | Effect of hyperglycemia and hyperinsulinemia on glutathione peroxidase activity in non-obese women with polycystic ovary syndrome |
| Q46558617 | Effects of antioxidant stobadine on protein carbonylation, advanced oxidation protein products and reductive capacity of liver in streptozotocin-diabetic rats: role of oxidative/nitrosative stress. |
| Q24595411 | Effects of tempol and redox-cycling nitroxides in models of oxidative stress |
| Q37805100 | Endothelial and cardiac progenitors: boosting, conditioning and (re)programming for cardiovascular repair. |
| Q35947546 | Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing |
| Q26851362 | Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? |
| Q37711251 | Endothelial dysfunction in diabetes: multiple targets for treatment |
| Q54729300 | Enhancement of BK(Ca) channel activity induced by hydrogen peroxide: involvement of lipid phosphatase activity of PTEN. |
| Q33857619 | Erythropoietin increases expression and function of vascular copper- and zinc-containing superoxide dismutase |
| Q49484658 | Essential role for EGFR tyrosine kinase and ER stress in myocardial infarction in type 2 diabetes |
| Q34620839 | Evaluation of neonatal streptozotocin induced diabetic rat model for the development of cataract. |
| Q38080708 | Evidence-based surgical management of acquired tricuspid valve disease |
| Q36459906 | Expression and transcriptional profiling of the LKB1 tumor suppressor in cervical cancer cells |
| Q58763474 | Expression profiling of ubiquitin-related genes in LKB1 mutant lung adenocarcinoma |
| Q85554915 | Extract of Clinopodium chinense inhibits high glucose-induced apoptosis in human umbilical vein endothelial cells |
| Q51326982 | Ganoderma atrum polysaccharide improves aortic relaxation in diabetic rats via PI3K/Akt pathway. |
| Q46135112 | Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes |
| Q34578822 | High concentrations of glucose reduce the oxidative metabolism of dog neutrophils in vitro. |
| Q37163511 | High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3-kinase/Akt signaling pathway and attenuates corneal epithelial wound healing |
| Q42988967 | High-glucose condition reduces cardioprotective effects of insulin against mechanical stress-induced cell injury |
| Q99556559 | Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice |
| Q85091800 | Hydrogen sulfide protects against high-glucose-induced apoptosis in endothelial cells |
| Q39571211 | Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactive nitrogen species-mediated Jun N-terminal kinase activation |
| Q57802862 | Hyperglycemia modulates redox, inflammatory and vasoactive markers through specific signaling pathways in cerebral endothelial cells: insights on insulin protective action |
| Q39532550 | Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. |
| Q100638802 | Immediate, early and mid-term outcomes following balloon mitral valvotomy in patients having severe rheumatic mitral stenosis with significant tricuspid regurgitation |
| Q37267054 | In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I |
| Q59537580 | Insulin Resistance in Non-Obese Women with Polycystic Ovary Syndrome: Relation to Byproducts of Oxidative Stress |
| Q38683468 | Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus |
| Q41551496 | KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition |
| Q39026772 | LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies |
| Q51955450 | LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment. |
| Q37868986 | LKB1 signaling in advancing cell differentiation |
| Q37333592 | LKB1; linking cell structure and tumor suppression |
| Q28592491 | Lkb1 deficiency causes prostate neoplasia in the mouse |
| Q45265720 | Lymphocyte-mediated macrophage apoptosis during IL-12 stimulation |
| Q38221717 | Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders. |
| Q37745268 | Mesenchymal stromal cells inhibit CD25 expression via the mTOR pathway to potentiate T-cell suppression |
| Q50100433 | Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts |
| Q37151577 | Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling |
| Q39470921 | MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. |
| Q34022332 | Molecular insights and therapeutic targets for diabetic endothelial dysfunction |
| Q37262124 | Molecular mechanisms and clinical implications of reversible protein S-glutathionylation |
| Q46037506 | Multiple mechanisms of soy isoflavones against oxidative stress-induced endothelium injury. |
| Q30994890 | NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways |
| Q39386420 | Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation. |
| Q35287252 | Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells. |
| Q38046547 | Oxidative stress and myocardial injury in the diabetic heart |
| Q51317623 | PTEN upregulation may explain the development of insulin resistance and type 2 diabetes with high dose statins. |
| Q92045259 | Peroxynitrite-Mediated SIRT (Sirtuin)-1 Inactivation Contributes to Nicotine-Induced Arterial Stiffness in Mice |
| Q53484375 | Phenotypic assessment of endothelial microparticles in diabetic and nondiabetic men with erectile dysfunction. |
| Q42972316 | Postprocedure administration of insulin in canine autologous vein grafting: a potential strategy to attenuate intimal hyperplasia |
| Q46640292 | Proapoptotic and antiapoptotic effects of hyperglycemia: role of insulin signaling |
| Q36727225 | Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells |
| Q37110784 | RETRACTED ARTICLE: Tert-butylhydroquinone lowers blood pressure in AngII-induced hypertension in mice via proteasome-PTEN-Akt-eNOS pathway |
| Q36761895 | Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo |
| Q38748962 | Redox control of skeletal muscle atrophy |
| Q28392484 | Redox regulation of endothelial cell fate |
| Q36415676 | Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats |
| Q96348276 | Regulating tumor suppressor genes: post-translational modifications |
| Q35925959 | Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems |
| Q36589883 | Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells |
| Q37761303 | Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity |
| Q51303874 | Role of nitric oxide and endothelin in endothelial maintenance of vasoconstrictor responses in aortas of diabetic female rats. |
| Q37159262 | Role of peroxynitrite in the redox regulation of cell signal transduction pathways |
| Q34637563 | Role of the phosphatase PTEN in early vascular remodeling. |
| Q38134021 | S-glutathionylation: relevance in diabetes and potential role as a biomarker. |
| Q37815730 | SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model |
| Q55034398 | Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways. |
| Q33813006 | Sildenafil reduces insulin-resistance in human endothelial cells |
| Q39495992 | Silk fibroin has a protective effect against high glucose induced apoptosis in HIT-T15 cells |
| Q50875204 | Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. |
| Q39632457 | Suppression of NADPH oxidase 2 substantially restores glucose‐induced dysfunction of pancreatic NIT‐1 cells |
| Q39255796 | T63, a new 4-arylidene curcumin analogue, induces cell cycle arrest and apoptosis through activation of the reactive oxygen species-FOXO3a pathway in lung cancer cells |
| Q38071485 | Targeting LKB1 signaling in cancer. |
| Q38323902 | Targeting the 5'-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer |
| Q55000155 | Tert-butylhydroquinone promotes angiogenesis and improves heart functions in rats after myocardial infarction. |
| Q46679679 | The Antioxidant N-Acetylcysteine Inhibits Inflammatory and Apoptotic Processes in Human Conjunctival Epithelial Cells in a High-Glucose Environment |
| Q46847292 | The effects of high glucose levels on reactive oxygen species-induced apoptosis and involved signaling in human vascular endothelial cells |
| Q46184635 | The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways |
| Q39530881 | The mitochondrial permeability transition pore regulates endothelial bioenergetics and angiogenesis. |
| Q54581112 | The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term. |
| Q92932394 | The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells |
| Q37285129 | Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling |
| Q37270444 | Understanding PTEN regulation: PIP2, polarity and protein stability |
| Q46116568 | Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats |
| Q92123515 | Up-regulation of microRNA-203 inhibits myocardial fibrosis and oxidative stress in mice with diabetic cardiomyopathy through the inhibition of PI3K/Akt signaling pathway via PIK3CA |
| Q39704421 | Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. |
| Q46125858 | Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes |
| Q53212855 | Zinc deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3. |
| Q46100245 | p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose |
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