LKB1; linking cell structure and tumor suppression

scientific article

LKB1; linking cell structure and tumor suppression is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/ONC.2008.342
P698PubMed publication ID19029933
P5875ResearchGate publication ID23493832

P2093author name stringN Bardeesy
A F Hezel
P2860cites workMolecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndromeQ42977726
Prevention of pancreatic cancer induction in hamsters by metforminQ43552285
Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.Q46890287
The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast divisionQ47071561
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.Q51716801
Genome-wide survey of protein kinases required for cell cycle progression.Q52654188
Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.Q53342336
Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.Q54190005
Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.Q54322682
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.Q54462818
Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and DigitsQ57073474
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndromeQ57240072
Identification of genes required for cytoplasmic localization in early C. elegans embryosQ68273724
Feminizing Sertoli cell tumors in boys with Peutz-Jeghers syndromeQ72361770
Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasmsQ73670302
LKB1 protein expression in neuroendocrine tumors of the lungQ80501532
Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant miceQ81461035
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeQ21245891
Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signalingQ24296680
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADQ24305094
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Q24310603
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruptionQ24313701
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposisQ24319729
AMPK phosphorylation of raptor mediates a metabolic checkpointQ24329244
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivoQ24531930
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndromeQ24655120
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancersQ24671334
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3Q24672153
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreasQ24685646
Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignumQ37375962
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient miceQ39995270
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activityQ40017323
Energy-dependent regulation of cell structure by AMP-activated protein kinaseQ40135869
LKB1/STRAD promotes axon initiation during neuronal polarization.Q40136806
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cellsQ40216291
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndromeQ41022988
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasmsQ41982039
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinaseQ42165233
Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent mannerQ42518946
LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning.Q42520723
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesisQ42547962
Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signallingQ42677856
Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis.Q42844340
Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromesQ42850964
Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signalingQ27851424
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanomaQ28141888
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1Q28189311
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowthQ28211693
The AMP-activated protein kinase cascade--a unifying system for energy controlQ28239257
LKB1 tumor suppressor protein: PARtaker in cell polarityQ28265461
The LKB1 tumor suppressor negatively regulates mTOR signalingQ28272728
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detectorQ28285140
Analysis of the LKB1-STRAD-MO25 complexQ28294900
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysisQ28300857
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Q28504452
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminQ28590162
LKB1 and SAD kinases define a pathway required for the polarization of cortical neuronsQ28591764
Lkb1 deficiency causes prostate neoplasia in the mouseQ28592491
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient miceQ28594689
Metformin and reduced risk of cancer in diabetic patientsQ29616275
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energyQ29618101
AMP-activated protein kinase induces a p53-dependent metabolic checkpointQ29618123
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epitheliaQ29618875
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosisQ29622875
LKB1 modulates lung cancer differentiation and metastasisQ30080027
Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signalingQ30444602
Peutz-Jeghers syndrome: 78-year follow-up of the original familyQ33601730
Peutz-Jeghers syndromeQ33679883
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contractionQ33841869
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposisQ34066238
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposisQ34156001
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomasQ34503041
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrestQ34504424
Very high risk of cancer in familial Peutz-Jeghers syndromeQ34512286
Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinomaQ34515560
Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).Q34523729
Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz-Jeghers syndromeQ34526950
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformationQ34527075
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarityQ34530696
Cancer and the Peutz-Jeghers syndromeQ34532616
Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interactionQ34533191
LKB1-dependent signaling pathwaysQ34535140
LKB1 (XEEK1) regulates Wnt signalling in vertebrate developmentQ34536922
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.Q34546258
Relative frequency and morphology of cancers in STK11 mutation carriersQ34548485
Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.Q34551816
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.Q34556342
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromesQ34558919
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndromeQ34562591
Peutz-Jeghers syndrome and management recommendationsQ34566543
Frequency and spectrum of cancers in the Peutz-Jeghers syndromeQ34567595
Increased risk of cancer in the Peutz-Jeghers syndromeQ34690977
PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cellsQ34886029
An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancersQ35394836
In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitisQ35594777
Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinaseQ35612267
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivoQ35720274
AMP-activated protein kinase regulates the assembly of epithelial tight junctionsQ35768585
LKB1 somatic mutations in sporadic tumorsQ35793276
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organizationQ35990220
LKB1 and AMPK maintain epithelial cell polarity under energetic stressQ36119701
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeletonQ36322073
Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cellsQ36573268
Glucose metabolism and cancerQ36625786
Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cellsQ36727225
Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patientsQ36785938
The Par-1/MARK family of protein kinases: from polarity to metabolismQ36919801
Dialogue between LKB1 and AMPK: a hot topic at the cellular poleQ36945343
LKB1 and AMPK in cell polarity and divisionQ37100013
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.Q37250634
Polarity proteins in migration and invasionQ37333610
Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA.Q37333631
P433issue55
P407language of work or nameEnglishQ1860
P304page(s)6908-6919
P577publication date2008-11-01
P1433published inOncogeneQ1568657
P1476titleLKB1; linking cell structure and tumor suppression
P478volume27

Reverse relations

cites work (P2860)
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