Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling

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Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1016975209
P356DOI10.1007/S00438-005-1124-Y
P698PubMed publication ID15731909
P5875ResearchGate publication ID8001583

P50authorStilianos AntonarakisQ15429287
Christelle BorelQ91710837
P2093author name stringNathalie Lin-Marq
P2860cites workComplexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeQ21245891
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell deathQ24291382
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/ArrowQ24291392
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1Q24291996
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmQ24296287
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADQ24305094
Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteinsQ24307824
Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxinQ24310542
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivoQ24531930
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesQ24534395
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneityQ24539769
GSK-3: tricks of the trade for a multi-tasking kinaseQ24624069
The WntsQ24802301
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinasesQ27939305
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1Q28189311
LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrestQ28205561
LKB1--a master tumour suppressor of the small intestine and beyondQ28208312
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowthQ28211693
Elastic fiber homeostasis requires lysyl oxidase-like 1 proteinQ28240976
Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor geneQ28250528
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinaseQ28258611
LKB1 tumor suppressor protein: PARtaker in cell polarityQ28265461
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysisQ28300857
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Q28504452
Causal relationship between the loss of RUNX3 expression and gastric cancerQ28509530
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarityQ28568803
Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder developmentQ28587688
Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and functionQ28591207
The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinaseQ28593509
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient miceQ28594689
LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 geneQ29616540
Caught up in a Wnt storm: Wnt signaling in cancerQ29617494
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complexQ31152974
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.Q33643620
Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathwaysQ33814311
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposisQ34066238
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposisQ34156001
Regulation of GSK-3: a cellular multiprocessorQ34299875
Increased risk for cancer in patients with the Peutz-Jeghers syndromeQ34472625
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrestQ34504424
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetryQ34507504
Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome.Q34512116
Very high risk of cancer in familial Peutz-Jeghers syndromeQ34512286
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout miceQ34522435
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformationQ34527075
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarityQ34530696
Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interactionQ34533191
LKB1, a protein kinase regulating cell proliferation and polarityQ34534892
LKB1 (XEEK1) regulates Wnt signalling in vertebrate developmentQ34536922
Correlation of Staining for LKB1 and COX-2 in Hamartomatous Polyps and Carcinomas from Patients with Peutz–Jeghers SyndromeQ34543277
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.Q34546258
Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryosQ34733393
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.Q34756366
Smad4/DPC4-mediated tumor suppression through suppression of angiogenesisQ35210772
Canonical Wnt signals are essential for homeostasis of the intestinal epitheliumQ39895829
Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.Q40673025
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.Q40674603
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndromeQ41022988
Immunolocalization of beta catenin in intestinal polyps of Peutz-Jeghers and juvenile polyposis syndromesQ42160195
Reduction of Cell Surface Fibronectin (LETS Protein) Correlates with Tumorigenicity of Hamster Fibroblasts Transformed by Herpes Simplex Virus Type 2Q45803883
Smooth muscle expresses bone morphogenetic protein (Vgr-1/BMP-6) in human fetal intestineQ46180828
Analysis of high density expression microarrays with signed-rank call algorithmsQ48611725
Robust estimators for expression analysisQ48611734
Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway.Q54783174
High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectorsQ73172777
Perinatal hypoxia-ischemia decreased neuronal but increased cerebral vascular endothelial IGFBP3 expressionQ73530524
Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patientsQ78109607
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectnegative regulation of canonical Wnt signaling pathwayQ14860027
Serine/threonine kinase 11Q21109306
Serine/threonine kinase 11Q21991188
P304page(s)184-96
P577publication date2005-04-01
P1433published inMolecular Genetics and GenomicsQ15753424
P1476titlePeutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling
P478volume273

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cites work (P2860)
Q35094301Endopancreatic bile duct cholangiocarcinoma in a patient with peutz-jeghers syndrome.
Q35853581Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung.
Q38829991GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells
Q54449617Immunohistological evidence for Wnt-signaling activation in Peutz-Jeghers polyposis.
Q24312214Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
Q55342073Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth.
Q42801148Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.
Q38994951LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
Q24655120LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome
Q37333592LKB1; linking cell structure and tumor suppression
Q50314061Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice
Q36016140Mucosal pigmentation caused by imatinib: report of three cases
Q81904177Osteogenic tumours in Lkb1-deficient mice
Q81993570Pigmentation of the hard palate
Q38838114RNA-seq analysis of the whole transcriptome of MDA-MB-231 mammary carcinoma cells exposed to the antimetastatic drug NAMI-A.
Q41677991Specific deletion of LKB1/Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice
Q34409196The biology of hyperpigmentation syndromes
Q39097606The tumor suppressor LKB1 antagonizes WNT signaling pathway through modulating GSK3β activity in cell growth of esophageal carcinoma
Q54486535Two variants in STK11 gene in Chinese patients with Peutz-Jeghers syndrome.

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