Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells

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Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...746055M
P356DOI10.1371/JOURNAL.PONE.0046055
P932PMC publication ID3460930
P698PubMed publication ID23029387
P5875ResearchGate publication ID231815731

P2093author name stringIvan Gorn-Hondermann
Jim Dimitroulakos
Khalil Dayekh
Laurie Ma
Nima Niknejad
P2860cites workAMP-Activated Protein Kinase in Metabolic Control and Insulin SignalingQ22241925
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Synergistic effect of bortezomib and valproic acid treatment on the proliferation and apoptosis of acute myeloid leukemia and myelodysplastic syndrome cellsQ39588189
p53 Protects lung cancer cells against metabolic stressQ39637062
Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteinsQ39690739
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Activation of the integrated stress response regulates lovastatin-induced apoptosisQ40094100
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A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervixQ45287290
Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptorQ46402596
Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approachQ58327250
Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatinQ67692210
HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cellsQ71031979
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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowthQ28211693
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Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammationQ28394373
EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cellsQ28478401
The importance of LDL and cholesterol metabolism for prostate epithelial cell growthQ28727920
Regulation of the mevalonate pathwayQ29547763
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STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.Q30441588
Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implicationsQ32016312
Dysregulation of the mevalonate pathway promotes transformationQ34093736
Epidermal growth factor receptor: mechanisms of activation and signalling.Q34185055
Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndromeQ34188044
Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmissionQ34226003
The EGF receptor family as targets for cancer therapyQ34293543
LKB1, a protein kinase regulating cell proliferation and polarityQ34534892
Mevalonate pathway: a review of clinical and therapeutical implicationsQ34623889
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.Q34754747
Regulation and targets of receptor tyrosine kinasesQ35045439
The statins as anticancer agentsQ35049816
Erlotinib (Tarceva): an update on the clinical trial programQ35168980
Targets and mechanisms for the regulation of translation in malignant transformationQ35750114
Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathwayQ36542484
Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders.Q36998738
Integrated endoplasmic reticulum stress responses in cancerQ37002431
The mammalian target of rapamycin pathway and its role in molecular nutrition regulationQ37096709
Role of LKB1 in lung cancer developmentQ37252718
LKB1; linking cell structure and tumor suppressionQ37333592
Translation initiation: a critical signalling node in cancerQ37586472
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen speciesQ37685389
The AMPK-FoxO3A axis as a target for cancer treatmentQ37700098
The PKB/AKT pathway in cancerQ37705534
LKB1 regulated pathways in lung cancer invasion and metastasisQ37811822
Metformin and cancer: new applications for an old drugQ37837675
The role of LKB1 and AMPK in cellular responses to stress and damageQ37852162
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcytotoxicityQ246181
squamous cell carcinomaQ681817
P304page(s)e46055
P577publication date2012-09-28
P1433published inPLOS OneQ564954
P1476titleLovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells
P478volume7

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cites work (P2860)
Q36327585Anti-tumor effects of metformin on head and neck carcinoma cell lines: A systematic review
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Q35670621In vitro Anti-Tumor Effects of Statins on Head and Neck Squamous Cell Carcinoma: A Systematic Review
Q36729421Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma
Q54978047Lactobacillus plantarum DR7 Reduces Cholesterol via Phosphorylation of AMPK That Down-regulated the mRNA Expression of HMG-CoA Reductase.
Q41004903Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation
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Q39130783Lovastatin-induced apoptosis is mediated by activating transcription factor 3 and enhanced in combination with salubrinal
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Q38760024Targeting autophagy as a strategy for drug discovery and therapeutic modulation
Q91607022The effects of statins on dental and oral health: a review of preclinical and clinical studies

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