scholarly article | Q13442814 |
P819 | ADS bibcode | 2012PLoSO...746055M |
P356 | DOI | 10.1371/JOURNAL.PONE.0046055 |
P932 | PMC publication ID | 3460930 |
P698 | PubMed publication ID | 23029387 |
P5875 | ResearchGate publication ID | 231815731 |
P2093 | author name string | Ivan Gorn-Hondermann | |
Jim Dimitroulakos | |||
Khalil Dayekh | |||
Laurie Ma | |||
Nima Niknejad | |||
P2860 | cites work | AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling | Q22241925 |
Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition | Q81347002 | ||
Synergistic effect of bortezomib and valproic acid treatment on the proliferation and apoptosis of acute myeloid leukemia and myelodysplastic syndrome cells | Q39588189 | ||
p53 Protects lung cancer cells against metabolic stress | Q39637062 | ||
Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins | Q39690739 | ||
Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy | Q39944174 | ||
Activation of the integrated stress response regulates lovastatin-induced apoptosis | Q40094100 | ||
Pharmacology of competitive inhibitors of HMG-CoA reductase. | Q40546774 | ||
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic | Q40745426 | ||
Inhibitors of prenyl transferases. | Q41643298 | ||
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice | Q43266332 | ||
A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix | Q45287290 | ||
Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor | Q46402596 | ||
Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach | Q58327250 | ||
Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin | Q67692210 | ||
HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cells | Q71031979 | ||
Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab | Q27346475 | ||
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth | Q28211693 | ||
The mTOR pathway and its role in human genetic diseases | Q28285976 | ||
Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation | Q28394373 | ||
EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells | Q28478401 | ||
The importance of LDL and cholesterol metabolism for prostate epithelial cell growth | Q28727920 | ||
Regulation of the mevalonate pathway | Q29547763 | ||
Translational control in stress and apoptosis | Q29615497 | ||
Coping with stress: eIF2 kinases and translational control | Q29619787 | ||
STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7. | Q30441588 | ||
Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications | Q32016312 | ||
Dysregulation of the mevalonate pathway promotes transformation | Q34093736 | ||
Epidermal growth factor receptor: mechanisms of activation and signalling. | Q34185055 | ||
Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome | Q34188044 | ||
Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission | Q34226003 | ||
The EGF receptor family as targets for cancer therapy | Q34293543 | ||
LKB1, a protein kinase regulating cell proliferation and polarity | Q34534892 | ||
Mevalonate pathway: a review of clinical and therapeutical implications | Q34623889 | ||
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. | Q34754747 | ||
Regulation and targets of receptor tyrosine kinases | Q35045439 | ||
The statins as anticancer agents | Q35049816 | ||
Erlotinib (Tarceva): an update on the clinical trial program | Q35168980 | ||
Targets and mechanisms for the regulation of translation in malignant transformation | Q35750114 | ||
Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway | Q36542484 | ||
Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. | Q36998738 | ||
Integrated endoplasmic reticulum stress responses in cancer | Q37002431 | ||
The mammalian target of rapamycin pathway and its role in molecular nutrition regulation | Q37096709 | ||
Role of LKB1 in lung cancer development | Q37252718 | ||
LKB1; linking cell structure and tumor suppression | Q37333592 | ||
Translation initiation: a critical signalling node in cancer | Q37586472 | ||
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species | Q37685389 | ||
The AMPK-FoxO3A axis as a target for cancer treatment | Q37700098 | ||
The PKB/AKT pathway in cancer | Q37705534 | ||
LKB1 regulated pathways in lung cancer invasion and metastasis | Q37811822 | ||
Metformin and cancer: new applications for an old drug | Q37837675 | ||
The role of LKB1 and AMPK in cellular responses to stress and damage | Q37852162 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 9 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cytotoxicity | Q246181 |
squamous cell carcinoma | Q681817 | ||
P304 | page(s) | e46055 | |
P577 | publication date | 2012-09-28 | |
P1433 | published in | PLOS One | Q564954 |
P1476 | title | Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells | |
P478 | volume | 7 |
Q36327585 | Anti-tumor effects of metformin on head and neck carcinoma cell lines: A systematic review |
Q89126294 | Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management |
Q27026428 | Chemopreventive drugs: mechanisms via inhibition of cancer stem cells in colorectal cancer |
Q35670621 | In vitro Anti-Tumor Effects of Statins on Head and Neck Squamous Cell Carcinoma: A Systematic Review |
Q36729421 | Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma |
Q54978047 | Lactobacillus plantarum DR7 Reduces Cholesterol via Phosphorylation of AMPK That Down-regulated the mRNA Expression of HMG-CoA Reductase. |
Q41004903 | Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation |
Q36845822 | Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade |
Q37402139 | Lovastatin lowers the risk of breast cancer: a population-based study using logistic regression with a random effects model |
Q36414323 | Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo |
Q39130783 | Lovastatin-induced apoptosis is mediated by activating transcription factor 3 and enhanced in combination with salubrinal |
Q38171577 | Metabolic stress and cancer: is autophagy the common denominator and a feasible target? |
Q46213230 | Metabolic targets for cancer therapy |
Q37745474 | Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth |
Q36235102 | Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway |
Q38760024 | Targeting autophagy as a strategy for drug discovery and therapeutic modulation |
Q91607022 | The effects of statins on dental and oral health: a review of preclinical and clinical studies |
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