STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas

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STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0002-9440(10)63053-2
P932PMC publication ID1850608
P698PubMed publication ID11733352

P50authorMarnix JansenQ77321797
Christophe RostyQ51118591
Michael GogginsQ63021511
P2093author name stringN Sato
C A Iacobuzio-Donahue
C J Yeo
R H Hruban
J L Cameron
T Ueki
N Fukushima
P2860cites workThe Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell deathQ24291382
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islandsQ24631957
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancersQ24671334
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinaseQ28258611
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancerQ28267211
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomasQ73555144
Intraductal papillary tumors and mucinous cystic tumors of the pancreas: clinicopathologic study of 38 casesQ73727599
Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entityQ74428893
Pattern of recurrence after resection for intraductal papillary mucinous tumors of the pancreasQ74797697
Clinicopathologic view of intraductal papillary-mucinous tumor of the pancreasQ78023166
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysisQ28300857
A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature.Q33647782
Progress in cancer genetics: lessons from pancreatic cancerQ33705143
Prevention of pancreatic cancer and strategies for management of familial pancreatic cancerQ34269104
Increased risk for cancer in patients with the Peutz-Jeghers syndromeQ34472625
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrestQ34504424
Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndromeQ34506538
Increased risk of cancer in the Peutz-Jeghers syndromeQ34690977
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patientsQ34722833
Tumor-suppressive pathways in pancreatic carcinoma.Q34739925
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumorsQ34747457
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.Q34754689
An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancersQ35394836
Genetic progression and heterogeneity in intraductal papillary-mucinous neoplasms of the pancreas.Q35764095
Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sectionsQ35764415
BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implicationsQ35810230
Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomasQ35829440
Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.Q36620205
Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesisQ36622459
Conversion of diploidy to haploidyQ40897610
Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five casesQ42075775
Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivationQ42791516
Intraductal neoplasms of the pancreasQ45111547
Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome, and nomenclature. Members of the Pancreas Clinic, and Pancreatic Surgeons of Mayo ClinicQ48785820
Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis.Q53398379
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.Q53439727
Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.Q54190005
Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and DigitsQ57073474
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndromeQ57240072
Cancer in Peutz-Jeghers syndromeQ70487226
Intraductal papillary mucinous neoplasms of the pancreas associated with so-called "mucinous ductal ectasia". Histochemical and immunohistochemical analysis of 29 casesQ72181018
An immunohistochemical study of the c-erbB-2 oncogene product in intraductal mucin-hypersecreting neoplasms and in ductal cell carcinomas of the pancreasQ72221463
Allelotype of pancreatic adenocarcinomaQ72386220
The prognosis of intraductal papillary mucinous tumors of the pancreasQ73046073
Atomic structure of the quasicrystal Al72Ni20Co8Q73412325
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpancreasQ9618
P304page(s)2017-2022
P577publication date2001-12-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleSTK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
P478volume159

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