Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome

scientific article

Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0002-9440(10)64735-9
P932PMC publication ID1868646
P698PubMed publication ID10623683

P50authorKathleen ChoQ69939385
P2093author name stringW A Cliby
D C Connolly
H Katabuchi
P2860cites workHuman Cancer Syndromes: Clues to the Origin and Nature of CancerQ22242264
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancersQ24671334
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanomaQ28141888
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinaseQ28258611
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancerQ28267211
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysisQ28300857
Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.Q33680045
Increased risk for cancer in patients with the Peutz-Jeghers syndromeQ34472625
Increased risk of cancer in the Peutz-Jeghers syndromeQ34690977
Peutz-Jeghers syndrome: confirmation of linkage to chromosome 19p13.3 and identification of a potential second locus, on 19q13.4.Q34743858
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumorsQ34747457
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.Q34752053
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.Q34754689
LKB1 somatic mutations in sporadic tumorsQ35793276
Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.Q36620205
Ovarian Tumors Associated with the Peutz-Jeghers SyndromeQ39991207
Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervixQ40342834
Disseminated cervical adenoma malignum and bilateral ovarian sex cord tumors with annular tubules associated with Peutz-Jeghers syndromeQ40755065
Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromesQ42850964
An integrated metric physical map of human chromosome 19.Q46045243
Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and DigitsQ57073474
Localization of the gene responsible for Peutz-Jeghers syndrome within a 6-cM region of chromosome 19p13.3Q57269499
Ovarian tumors: an extension of the Peutz-Jeghers syndromeQ68630046
Sex cord tumor with annular tubules a distinctive ovarian tumor of the Peutz-Jeghers syndromeQ71462652
Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19pQ73677692
A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervixQ74356004
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)339-345
P577publication date2000-01-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleSomatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome
P478volume156

Reverse relations

cites work (P2860)
Q28307804A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome
Q39257685A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region.
Q38998413AMPK and Cancer
Q38813996Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature.
Q31045942Different pattern of loss of heterozygosity among endocervical-type adenocarcinoma, endometrioid-type adenocarcinoma and adenoma malignum of the uterine cervix
Q36059087Do hereditary syndrome-related gynecologic cancers have any specific features?
Q37271839Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates
Q51647531Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas.
Q83767560Hamartomatous polyposis syndromes
Q37269300Hereditary gynecological tumors associated with Peutz-Jeghers syndrome (Review)
Q92840003Histological changes of non-Peutz-Jegher syndrome associated ovarian sex cord tumor with annular tubules in childhood
Q33721668Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells
Q33521710Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.
Q34553801LKB1, the multitasking tumour suppressor kinase
Q34899298Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers
Q36234845Mutations in the human LKB1/STK11 gene
Q34568396Nasal polyposis in Peutz-Jeghers syndrome: a distinct histopathological and molecular genetic entity
Q37041908Ovarian Sex-cord Tumour with Peutz-Jeghers Polyp and Giant Keratoacanthoma
Q54019418Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease.
Q38808384Rare non-epithelial ovarian neoplasms: Pathology, genetics and treatment
Q24685646STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
Q33425903Somatic LKB1 mutations promote cervical cancer progression
Q36371563Virilizing leydig-sertoli cell ovarian tumor associated with endometrioid carcinoma of the endometrium in a postmenopausal patient: case report and general considerations

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