Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer

scientific article published on 17 October 2013

Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JNCI/DJT249
P932PMC publication ID3818169
P698PubMed publication ID24136889

P50authorDingxie LiuQ55459885
P2093author name stringAvaniyapuram Kannan Murugan
Mingzhao Xing
Ermal Bojdani
Chongfei Yang
P2860cites workGenetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancerQ37767709
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The GTPase-activating NF1 fragment of 91 amino acids reverses v-Ha-Ras-induced malignant phenotypeQ38315079
Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression.Q39920036
The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathwaysQ40210019
Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis.Q40583206
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activationQ40787356
The neurofibromatosis type 1 gene and its protein product, neurofibromin.Q40890889
Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant.Q53569559
Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors.Q54513531
Large majority of single-nucleotide mutations along the dystrophin gene can be explained by more than one mechanism of mutagenesisQ73441578
Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancerQ79819385
Tumour suppressors: Role of nuclear PTEN revealedQ83751989
Global cancer statisticsQ22241238
Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancerQ24685746
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Q27690752
Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with RasQ27734180
cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell lineQ28117244
Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53Q28204132
Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancerQ28253304
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicityQ28257022
Stops along the RAS pathway in human genetic diseaseQ28300658
A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see commetns]Q31942209
Ras proteins: recent advances and new functions.Q33771484
The NF1 tumor suppressor critically regulates TSC2 and mTOR.Q33841600
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progressionQ33934897
Spred is a Sprouty-related suppressor of Ras signallingQ34086194
Molecular pathogenesis and mechanisms of thyroid cancerQ34329018
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotypeQ34664172
Genetics of neurofibromatosis 1 and the NF1 geneQ34982028
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activationQ35578577
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.Q35927921
BRAF mutation in thyroid cancerQ36157661
The genetic and molecular pathogenesis of NF1 and NF2.Q36526233
BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implicationsQ36972859
Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressorQ37124492
LKB1; linking cell structure and tumor suppressionQ37333592
Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycinQ37373348
The RASSF proteins in cancer; from epigenetic silencing to functional characterizationQ37432498
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectthyroid cancerQ826522
P304page(s)1617-1627
P577publication date2013-10-17
P1433published inJournal of the National Cancer InstituteQ400279
P1476titleIdentification of RASAL1 as a major tumor suppressor gene in thyroid cancer
P478volume105

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cites work (P2860)
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