The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

scientific article

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049865214
P356DOI10.1038/NATURE09572
P932PMC publication ID3037591
P698PubMed publication ID21124451
P5875ResearchGate publication ID49651540

P50authorNabeel BardeesyQ30004507
Francesco FerrariQ37371337
Orian S ShirihaiQ37837313
Borja SaezQ61159850
David T ScaddenQ88652265
P2093author name stringBrinda Alagesan
Fatih Ozsolak
Peter J Park
Nabeel Bardeesy
Rushdia Z Yusuf
Sushma Gurumurthy
Patrice Milos
Alexandros Tzatsos
Judith Kim
Stephanie Z Xie
P2860cites workComplexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeQ21245891
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Q24310603
A scaling normalization method for differential expression analysis of RNA-seq dataQ24628783
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3Q24672153
A ubiquitin-like system mediates protein lipidationQ27934137
The LKB1 tumor suppressor negatively regulates mTOR signalingQ28272728
A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndromeQ28307804
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminQ28590162
Inducible gene targeting in miceQ29614544
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsQ29615006
The LKB1-AMPK pathway: metabolism and growth control in tumour suppressionQ29617506
Self-eating and self-killing: crosstalk between autophagy and apoptosisQ29617748
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energyQ29618101
Restoration of p53 function leads to tumour regression in vivoQ29618727
Bmi1 regulates mitochondrial function and the DNA damage response pathwayQ34017298
Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.Q34100394
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformationQ34527075
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cellsQ34679984
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cellsQ34690043
Direct RNA sequencingQ35004834
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative diseaseQ36056927
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen speciesQ36916367
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilizationQ36995422
Advances in measuring cellular bioenergetics using extracellular fluxQ37110791
FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic systemQ37121014
Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.Q37123940
LKB1; linking cell structure and tumor suppressionQ37333592
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumorsQ37410764
EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in miceQ40079342
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndromeQ41022988
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasmsQ41982039
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesisQ42547962
IFNalpha activates dormant haematopoietic stem cells in vivo.Q44358922
Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survivalQ47069255
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.Q51716801
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.Q51998747
P433issue7324
P407language of work or nameEnglishQ1860
P304page(s)659-663
P577publication date2010-12-01
P1433published inNatureQ180445
P1476titleThe Lkb1 metabolic sensor maintains haematopoietic stem cell survival
P478volume468

Reverse relations

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