scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1049865214 |
P356 | DOI | 10.1038/NATURE09572 |
P932 | PMC publication ID | 3037591 |
P698 | PubMed publication ID | 21124451 |
P5875 | ResearchGate publication ID | 49651540 |
P50 | author | Nabeel Bardeesy | Q30004507 |
Francesco Ferrari | Q37371337 | ||
Orian S Shirihai | Q37837313 | ||
Borja Saez | Q61159850 | ||
David T Scadden | Q88652265 | ||
P2093 | author name string | Brinda Alagesan | |
Fatih Ozsolak | |||
Peter J Park | |||
Nabeel Bardeesy | |||
Rushdia Z Yusuf | |||
Sushma Gurumurthy | |||
Patrice Milos | |||
Alexandros Tzatsos | |||
Judith Kim | |||
Stephanie Z Xie | |||
P2860 | cites work | Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade | Q21245891 |
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 | Q24310603 | ||
A scaling normalization method for differential expression analysis of RNA-seq data | Q24628783 | ||
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress | Q24633606 | ||
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3 | Q24672153 | ||
A ubiquitin-like system mediates protein lipidation | Q27934137 | ||
The LKB1 tumor suppressor negatively regulates mTOR signaling | Q28272728 | ||
A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome | Q28307804 | ||
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin | Q28590162 | ||
Inducible gene targeting in mice | Q29614544 | ||
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells | Q29615006 | ||
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression | Q29617506 | ||
Self-eating and self-killing: crosstalk between autophagy and apoptosis | Q29617748 | ||
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy | Q29618101 | ||
Restoration of p53 function leads to tumour regression in vivo | Q29618727 | ||
Bmi1 regulates mitochondrial function and the DNA damage response pathway | Q34017298 | ||
Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. | Q34100394 | ||
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation | Q34527075 | ||
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells | Q34679984 | ||
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells | Q34690043 | ||
Direct RNA sequencing | Q35004834 | ||
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease | Q36056927 | ||
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species | Q36916367 | ||
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization | Q36995422 | ||
Advances in measuring cellular bioenergetics using extracellular flux | Q37110791 | ||
FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system | Q37121014 | ||
Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS. | Q37123940 | ||
LKB1; linking cell structure and tumor suppression | Q37333592 | ||
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors | Q37410764 | ||
EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice | Q40079342 | ||
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome | Q41022988 | ||
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms | Q41982039 | ||
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis | Q42547962 | ||
IFNalpha activates dormant haematopoietic stem cells in vivo. | Q44358922 | ||
Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival | Q47069255 | ||
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. | Q51716801 | ||
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes. | Q51998747 | ||
P433 | issue | 7324 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 659-663 | |
P577 | publication date | 2010-12-01 | |
P1433 | published in | Nature | Q180445 |
P1476 | title | The Lkb1 metabolic sensor maintains haematopoietic stem cell survival | |
P478 | volume | 468 |
Q43195305 | A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance |
Q51559123 | A ROSy future for metabolic regulation of HSC division. |
Q35285480 | A divergent role of the SIRT1-TopBP1 axis in regulating metabolic checkpoint and DNA damage checkpoint. |
Q36135727 | AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow |
Q34871517 | AMPK at the nexus of energetics and aging. |
Q48130504 | AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. |
Q28709232 | Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt |
Q33753813 | Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation |
Q92501988 | Ampk regulates IgD expression but not energy stress with B cell activation |
Q38827647 | An enduring role for quiescent stem cells |
Q34258176 | Anomalies in network bridges involved in bile Acid metabolism predict outcomes of colorectal cancer patients |
Q47291946 | Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells |
Q38257296 | Autophagy in T-cell development, activation and differentiation |
Q38271354 | Autophagy in cancer stem/progenitor cells |
Q90661029 | Autophagy, cancer stem cells and drug resistance |
Q44603723 | Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration |
Q37155867 | Cancer metabolism: fatty acid oxidation in the limelight |
Q93162228 | Cancer stemness, intratumoral heterogeneity, and immune response across cancers |
Q37460217 | Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells |
Q36861673 | Concise review: hematopoietic stem cell aging, life span, and transplantation |
Q34647637 | Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells |
Q35977660 | Connecting Mitochondria, Metabolism, and Stem Cell Fate |
Q37069494 | Control of adult stem cells in vivo by a dynamic physiological environment: diet-dependent systemic factors in Drosophila and beyond |
Q54982139 | Controlling the master-upstream regulation of the tumor suppressor LKB1. |
Q42087817 | D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL. |
Q36514929 | Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism |
Q41859179 | Deletion of Lkb1 in adult mice results in body weight reduction and lethality. |
Q98306008 | Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory |
Q41135408 | Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2. |
Q38003249 | Developmental decisions: balancing genetics and the environment by C. elegans |
Q33893826 | Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation |
Q37711151 | Dietary and metabolic control of stem cell function in physiology and cancer |
Q45542226 | Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis |
Q28507620 | Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development |
Q36776429 | Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques of ApoE(-/-) Mice |
Q58590553 | Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells |
Q38120954 | Emerging technologies for non-invasive quantification of physiological oxygen transport in plants. |
Q36619432 | Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate |
Q37994998 | Energy metabolism and proliferation in pancreatic carcinogenesis |
Q36849638 | Evolving role of adiponectin in cancer-controversies and update |
Q58763474 | Expression profiling of ubiquitin-related genes in LKB1 mutant lung adenocarcinoma |
Q37235699 | FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function |
Q38670200 | Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues |
Q40292794 | Fate through fat: lipid metabolism determines stem cell division outcome |
Q35878818 | Fish Oil-Rich Diet Promotes Hematopoiesis and Alters Hematopoietic Niche. |
Q57767553 | From tissue turnover to the cell of origin for pancreatic cancer |
Q27013811 | GSK-3 as potential target for therapeutic intervention in cancer |
Q28590221 | Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development |
Q37344781 | Genetic control of quiescence in hematopoietic stem cells |
Q35592116 | Gfer is a critical regulator of HSC proliferation |
Q51803668 | HSC Niche Biology and HSC Expansion Ex Vivo. |
Q35578618 | Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity |
Q88882249 | Hematopoietic stem cell fate through metabolic control |
Q36010278 | Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress |
Q36618609 | Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. |
Q26853702 | Hypoxia and metabolic properties of hematopoietic stem cells |
Q38876919 | Immunometabolism: an emerging frontier |
Q46233525 | Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging. |
Q34471792 | Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning |
Q37896565 | Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in. |
Q35907071 | Integrating physiological regulation with stem cell and tissue homeostasis |
Q36560365 | LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response |
Q38034266 | LKB1 and AMPK: central regulators of lymphocyte metabolism and function |
Q39026772 | LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies |
Q41072650 | LKB1 couples glucose metabolism to insulin secretion in mice. |
Q92802463 | LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells |
Q37850361 | LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor |
Q43195478 | LKB1 in transmembrane receptor signaling |
Q35743804 | LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation |
Q37687396 | LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors |
Q92614739 | LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity |
Q35226548 | LKB1 reduces ROS-mediated cell damage via activation of p38. |
Q48569187 | LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development |
Q92060189 | LKB1 specifies neural crest cell fates through pyruvate-alanine cycling |
Q38041715 | Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice |
Q90414218 | Lipid Mediated Regulation of Adult Stem Cell Behavior |
Q53744298 | Live kinase B1 maintains CD34+CD38- AML cell proliferation and self-renewal. |
Q50061471 | Liver Kinase B1 Links Macrophage Metabolism Sensing and Atherosclerosis |
Q64243712 | Liver Kinase B1-A Potential Therapeutic Target in Hormone-Sensitive Breast Cancer in Older Women |
Q91003394 | Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis |
Q35002962 | Liver kinase B1 suppresses lipopolysaccharide-induced nuclear factor κB (NF-κB) activation in macrophages |
Q51039334 | Lkb1 deletion in murine B lymphocytes promotes cell death and cancer. |
Q42044480 | Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis |
Q39076554 | Lkb1 regulation of skeletal muscle development, metabolism and muscle progenitor cell homeostasis. |
Q35978253 | Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects |
Q91451119 | MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer |
Q38008341 | Macrophages in injured skeletal muscle: a perpetuum mobile causing and limiting fibrosis, prompting or restricting resolution and regeneration |
Q36457006 | Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways |
Q35153207 | Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism |
Q37284264 | Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. |
Q57269850 | Mechanism and medical implications of mammalian autophagy |
Q34482050 | Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. |
Q39012510 | Mechanistic roles of autophagy in hematopoietic differentiation |
Q35960806 | Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion |
Q39146524 | Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer |
Q36653551 | Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis |
Q47151991 | Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. |
Q41667201 | Metabolic gatekeeper function of B-lymphoid transcription factors |
Q37077388 | Metabolic plasticity and hematopoietic stem cell biology |
Q36670513 | Metabolic plasticity in stem cell homeostasis and differentiation |
Q34240794 | Metabolic regulation of redox status in stem cells |
Q37333099 | Metabolic regulation of the cell cycle |
Q33893346 | Metabolic requirements for the maintenance of self-renewing stem cells |
Q36820974 | Metabolic switching and fuel choice during T-cell differentiation and memory development |
Q64906270 | Metabolic traits of cancer stem cells. |
Q41370769 | Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal |
Q36205053 | Metformin impairs the growth of liver kinase B1-intact cervical cancer cells. |
Q38793351 | Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs |
Q51503055 | MicroRNA-17 promotes normal ovarian cancer cells to cancer stem cells development via suppression of the LKB1-p53-p21/WAF1 pathway. |
Q41866335 | Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells |
Q39389934 | Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination |
Q91942051 | Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities |
Q43111405 | Mitochondria underlie different metabolism of hematopoietic stem and progenitor cells |
Q42257679 | Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: new insight into the role of mitophagy in cell stemness |
Q36078562 | Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3. |
Q50137432 | Mitochondrial regulation of hematopoietic stem cells |
Q26865108 | Mitophagy in hematopoietic stem cells: the case for exploration |
Q37718339 | Modelling mammalian cellular quiescence |
Q37256787 | Molecular regulation of stem cell quiescence. |
Q37460101 | Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. |
Q91706410 | NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer |
Q30244650 | New Roles of Lkb1 in Regulating Adipose Tissue Development and Thermogenesis |
Q41156597 | Newly Identified Roles of PML in Stem Cell Biology |
Q28513787 | Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells |
Q27011433 | Nutrient-sensing pathways and metabolic regulation in stem cells |
Q89977010 | Oral Microbes and Mucosal Dendritic Cells, "Spark and Flame" of Local and Distant Inflammatory Diseases |
Q37132896 | Oxidants, metabolism, and stem cell biology |
Q33663198 | PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo |
Q47142868 | Phe354Leu Polymorphism of LKB1 Is a Potential Prognostic Factor for Cytogenetically Normal Acute Myeloid Leukemia. |
Q47563636 | Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells |
Q36544315 | Pre-transplant weight loss predicts inferior outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndrome |
Q28086990 | Progenitor cell dysfunctions underlie some diabetic complications |
Q34311557 | Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis. |
Q36544596 | Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches. |
Q54122656 | Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. |
Q90291199 | Quercetin has a protective effect on atherosclerosis via enhancement of autophagy in ApoE-/- mice |
Q64921821 | Quiescence Entry, Maintenance, and Exit in Adult Stem Cells. |
Q29619605 | RNA sequencing: advances, challenges and opportunities |
Q39814876 | Re-sensitization of radiation resistant colorectal cancer cells to radiation through inhibition of AMPK pathway |
Q36157753 | Regulation and function of mTOR signalling in T cell fate decisions |
Q39134073 | Regulation of Hematopoiesis and Hematological Disease by TGF-β Family Signaling Molecules |
Q43505907 | Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells |
Q37859337 | Regulation of reactive oxygen species in stem cells and cancer stem cells. |
Q38143364 | Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells. |
Q38848055 | Resveratrol-downregulated phosphorylated liver kinase B1 is involved in senescence of acute myeloid leukemia stem cells |
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Q37854547 | Role of LKB1-SAD/MARK pathway in neuronal polarization |
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