scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | James A. McCubrey | Q42317570 |
Roberta Maestro | Q55278822 | ||
Giuseppe Montalto | Q56806930 | ||
Ferdinando Nicoletti | Q84521195 | ||
Massimo Libra | Q37842996 | ||
P2093 | author name string | F E Bertrand | |
A M Martelli | |||
L Cocco | |||
N M Davis | |||
F Nicoletti | |||
M Cervello | |||
L S Steelman | |||
S L Abrams | |||
A B D'Assoro | |||
J Basecke | |||
P2860 | cites work | Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation | Q24298234 |
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin | Q24313571 | ||
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling | Q24316697 | ||
GSK-3: tricks of the trade for a multi-tasking kinase | Q24624069 | ||
Regulation of myeloid leukaemia by the cell-fate determinant Musashi | Q24634359 | ||
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling | Q24673748 | ||
Wnt/β-catenin signaling and disease | Q26823272 | ||
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development | Q26997109 | ||
The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division | Q27934794 | ||
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling | Q28118465 | ||
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family | Q28139153 | ||
Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways | Q28177635 | ||
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 | Q28205234 | ||
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation | Q28208407 | ||
Wnt-5a has tumor suppressor activity in thyroid carcinoma | Q28237192 | ||
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth | Q28262401 | ||
NUMB controls p53 tumour suppressor activity | Q28263413 | ||
DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway | Q28283034 | ||
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction | Q28286117 | ||
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization | Q28290083 | ||
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta | Q28345704 | ||
Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer | Q28484291 | ||
Molecular cloning and expression of glycogen synthase kinase-3/factor A | Q28569645 | ||
GSK-3-mediated phosphorylation enhances Maf-transforming activity | Q28576703 | ||
A role for Wnt signalling in self-renewal of haematopoietic stem cells | Q28592213 | ||
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors | Q28640916 | ||
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML | Q29614278 | ||
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor | Q29614622 | ||
Wnt proteins are lipid-modified and can act as stem cell growth factors | Q29615009 | ||
WNT signalling pathways as therapeutic targets in cancer | Q29615666 | ||
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer | Q29616163 | ||
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells | Q29616552 | ||
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation | Q29618700 | ||
p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies | Q37874926 | ||
Notch signaling in mammalian hematopoietic stem cells | Q37885708 | ||
Acquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycle | Q37924479 | ||
GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease | Q38020439 | ||
Involvement of glycogen synthase kinase-3β in arsenic trioxide-induced p21 expression | Q38337710 | ||
GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb | Q38394964 | ||
Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia. | Q39344848 | ||
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency | Q39357822 | ||
Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors | Q39376795 | ||
Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype | Q39380262 | ||
Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway | Q39426971 | ||
The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation | Q39437383 | ||
Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts. | Q39441263 | ||
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications. | Q39463725 | ||
Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells | Q39468269 | ||
Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis. | Q39472188 | ||
Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration | Q39498392 | ||
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells | Q39562043 | ||
Overexpression of glycogen synthase kinase-3 in ovarian carcinoma cells with acquired paclitaxel resistance | Q39570859 | ||
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia. | Q39590044 | ||
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells | Q39620290 | ||
Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain | Q39657191 | ||
Inhibition of glycogen synthase kinase-3. | Q39903047 | ||
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. | Q39937420 | ||
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer | Q40012100 | ||
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines | Q40125072 | ||
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. | Q40350197 | ||
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event | Q40624453 | ||
Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathway | Q40700367 | ||
The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP. | Q40704880 | ||
Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling | Q40866028 | ||
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. | Q41290971 | ||
Glycogen synthase kinase-3 and cancer: good cop, bad cop? | Q41331262 | ||
Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells | Q41878659 | ||
Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML. | Q42140104 | ||
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. | Q42723875 | ||
Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation | Q42809920 | ||
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance | Q43195305 | ||
Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells | Q43599325 | ||
Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2. | Q43631715 | ||
Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation | Q43847013 | ||
PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response | Q45038180 | ||
Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides | Q46145961 | ||
t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism | Q46805127 | ||
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism | Q46972415 | ||
Activation of the Wnt signaling pathway: a molecular mechanism for lithium action | Q48958687 | ||
Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway. | Q49043307 | ||
Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin | Q50336867 | ||
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia. | Q50506558 | ||
Haematological effects of lithium carbonate: a study in 56 psychiatric patients. | Q52100755 | ||
Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. | Q52162599 | ||
Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15). | Q53409042 | ||
Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells. | Q54301591 | ||
Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1. | Q54334679 | ||
Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation. | Q54338655 | ||
GSK-3 inhibition in vitro and in vivo enhances antitumor effect of sorafenib in renal cell carcinoma (RCC). | Q54505454 | ||
GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells. | Q54571860 | ||
Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle | Q56456617 | ||
Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells | Q61041081 | ||
Increased number of peripheral blood CD34+ cells in lithium-treated patients | Q74122337 | ||
Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase | Q77944438 | ||
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue | Q79358419 | ||
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance | Q81308407 | ||
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin | Q81375017 | ||
Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells | Q83289914 | ||
Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway | Q84264128 | ||
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. | Q35857078 | ||
CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine | Q35865075 | ||
Pharmaceutical inhibition of glycogen synthetase kinase-3β reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model | Q35868347 | ||
Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells | Q35900933 | ||
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma | Q35919057 | ||
β-Arrestin2 mediates the initiation and progression of myeloid leukemia. | Q36140375 | ||
Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways | Q36457006 | ||
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo | Q36488720 | ||
Glycogen synthase kinase-3--an overview of an over-achieving protein kinase | Q36651778 | ||
γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin | Q36732802 | ||
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species | Q36916367 | ||
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. | Q37001651 | ||
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells | Q37097180 | ||
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation | Q37106907 | ||
Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration | Q37273048 | ||
Role of glycogen synthase kinase-3beta in cardioprotection | Q37303154 | ||
Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. | Q37452373 | ||
Glycogen synthase kinase 3 beta: can it be a target for oral cancer | Q37764097 | ||
The medicinal chemistry of novel iron chelators for the treatment of cancer. | Q37824720 | ||
Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling | Q37856426 | ||
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. | Q37865381 | ||
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice | Q30485018 | ||
Failure of lithium to limit neutropenia significantly during induction therapy of acute myelogenous leukemia. A Southeastern Cancer Study Group study. | Q33478283 | ||
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death | Q33710200 | ||
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling | Q33927142 | ||
Glycogen synthase kinase 3 is an insulin-regulated C/EBPalpha kinase | Q33960787 | ||
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres | Q34075159 | ||
GSK3 is a regulator of RAR-mediated differentiation | Q34119834 | ||
NUMB-ing down cancer by more than just a NOTCH. | Q34143037 | ||
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells | Q34149498 | ||
Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation. | Q34153063 | ||
The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia | Q34156754 | ||
Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia | Q34156762 | ||
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway | Q34173253 | ||
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias | Q34212654 | ||
Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers. | Q34225338 | ||
Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase | Q34251769 | ||
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival | Q34568200 | ||
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling | Q34574774 | ||
PML targeting eradicates quiescent leukaemia-initiating cells | Q34591761 | ||
Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation | Q34621025 | ||
Generation of multipotential mesendodermal progenitors from mouse embryonic stem cells via sustained Wnt pathway activation | Q34665776 | ||
Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation | Q34905557 | ||
What Are the bona fide GSK3 Substrates? | Q35001234 | ||
The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis. | Q35026699 | ||
Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells | Q35070240 | ||
Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response | Q35108092 | ||
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice | Q35187043 | ||
MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. | Q35256272 | ||
Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence | Q35256323 | ||
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons | Q35563894 | ||
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation | Q35571394 | ||
Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity | Q35763147 | ||
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib | Q35774432 | ||
WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. | Q35840116 | ||
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization | Q35857019 | ||
P275 | copyright license | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported | Q19125045 |
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | enzyme | Q8047 |
armadillo domain proteins | Q4792547 | ||
leukemia | Q29496 | ||
peptide | Q172847 | ||
transcription factor | Q407384 | ||
hemopoiesis | Q919283 | ||
carcinogenesis | Q1637543 | ||
beta-catenin | Q24783665 | ||
cytoskeletal proteins | Q66563066 | ||
macromolecular substance | Q75174158 | ||
Wnt proteins | Q77938923 | ||
P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
P304 | page(s) | 15-33 | |
P577 | publication date | 2013-06-19 | |
2014-01-01 | |||
P1433 | published in | Leukemia | Q6534498 |
P1476 | title | Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention | |
P478 | volume | 28 |
Q37075360 | A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity |
Q52668830 | A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase. |
Q34483490 | A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer |
Q89129402 | AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells |
Q99711172 | Activation of Type 4 Metabotropic Glutamate Receptor Regulates Proliferation and Neuronal Differentiation in a Cultured Rat Retinal Progenitor Cell Through the Suppression of the cAMP/PTEN/AKT Pathway |
Q37589666 | Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes |
Q51335065 | Aluminum Trichloride Inhibited Osteoblastic Proliferation and Downregulated the Wnt/β-Catenin Pathway. |
Q42105697 | An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3β signaling in breast cancer cells |
Q39247115 | Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis |
Q39614255 | Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma |
Q37108042 | CD147 modulates androgen receptor activity through the Akt/Gsk-3β/β-catenin/AR pathway in prostate cancer cells |
Q28084610 | CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells |
Q58697956 | CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression |
Q41610540 | Characterization of the novel indolylmaleimides' PDA-66 and PDA-377 effect on canine lymphoma cells |
Q99637584 | Cleavage of HSP90β induced by histone deacetylase inhibitor and proteasome inhibitor modulates cell growth and apoptosis |
Q89896759 | Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo |
Q38892306 | Combined inhibition of β-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo |
Q59129152 | Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture |
Q40971143 | Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells |
Q48157628 | Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin. |
Q58617350 | Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML |
Q49882954 | Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression |
Q52668632 | Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. |
Q35542173 | Expression and function of connexin 43 in human gingival wound healing and fibroblasts |
Q90304508 | Extracellular vesicle-mediated crosstalk between NPCE cells and TM cells result in modulation of Wnt signalling pathway and ECM remodelling |
Q41461266 | GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation |
Q27013811 | GSK-3 as potential target for therapeutic intervention in cancer |
Q38695750 | GSK-3β suppresses HCC cell dissociation in vitro by upregulating epithelial junction proteins and inhibiting Wnt/β-catenin signaling pathway |
Q38716760 | Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. |
Q37696169 | Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma |
Q33747040 | Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism |
Q38272835 | Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases |
Q93034488 | Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses |
Q41225033 | HDAC1 controls CIP2A transcription in human colorectal cancer cells |
Q46652753 | High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor |
Q37457938 | Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models |
Q51731135 | Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway. |
Q37692593 | Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells |
Q36022772 | Inhibition of β-Catenin to Overcome Endocrine Resistance in Tamoxifen-Resistant Breast Cancer Cell Line |
Q26822956 | Keeping Wnt signalosome in check by vesicular traffic |
Q37620821 | Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma |
Q53644558 | Letter to the editor: An intriguing relationship between lipid droplets, cholesterol-binding protein CD133 and Wnt/β-catenin signaling pathway in carcinogenesis. |
Q54263446 | Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent. |
Q90048237 | Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer |
Q46606963 | Neuroprotective Potential of Novel Multi-Targeted Isoalloxazine Derivatives in Rodent Models of Alzheimer's Disease Through Activation of Canonical Wnt/β-Catenin Signalling Pathway |
Q46491430 | Niclosamide Prevents Systemic Sclerosis in a Reactive Oxygen Species-Induced Mouse Model. |
Q38650702 | Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations |
Q91844680 | Nucleolin promotes Wnt signaling in human hematopoietic stem/progenitor cells |
Q61444792 | Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia |
Q42378393 | Opposing roles of ICAT and Wnt/β-catenin signaling in NSC67657-induced monocytic differentiation |
Q39008696 | Pharmacophore-based screening and drug repurposing exemplified on glycogen synthase kinase-3 inhibitors. |
Q36324321 | Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients |
Q54246485 | Porcine Circovirus-Like Virus P1 Inhibits Wnt Signaling Pathway in Vivo and in Vitro. |
Q38829884 | Posttranslational modification of E-cadherin by core fucosylation regulates Src activation and induces epithelial-mesenchymal transition-like process in lung cancer cells |
Q35081538 | Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease |
Q39211921 | Potential role of Wnt/β-catenin signaling in blastic transformation of chronic myeloid leukemia: cross talk between β-catenin and BCR-ABL. |
Q38696089 | Proinsulin Promotes Self-Renewal of a Hematopoietic Progenitor Cell Line In Vitro |
Q92458728 | Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-catenin and AKT/GSK3β proliferative signaling |
Q38885106 | Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood |
Q28072650 | Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells |
Q58585886 | Rosmarinic Acid Derivatives' Inhibition of Glycogen Synthase Kinase-3β Is the Pharmacological Basis of Kangen-Karyu in Alzheimer's Disease |
Q36205970 | SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML. |
Q37662240 | ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3β/β-catenin signaling pathway |
Q38431358 | Shikonin changes the lipopolysaccharide-induced expression of inflammation-related genes in macrophages |
Q54345704 | Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/B preferentially within a protective bone marrow microenvironment. |
Q54373992 | Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. |
Q28271278 | Survival regulation of leukemia stem cells |
Q37058793 | The clinical significance of γ-catenin in acute myeloid leukemia |
Q47237041 | The protective effect of PFTα on alcohol-induced osteonecrosis of the femoral head |
Q52889828 | The tumor suppressive role of RASSF1A in osteosarcoma through the Wnt signaling pathway. |
Q64061073 | Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer |
Q39306017 | Wnt Signaling in Normal and Malignant Stem Cells |
Q38411147 | Wnt3A Induces GSK-3β Phosphorylation and β-Catenin Accumulation Through RhoA/ROCK. |
Q57801751 | miR-29s function as tumor suppressors in gliomas by targeting TRAF4 and predict patient prognosis |
Q53120406 | microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. |
Q54117203 | β-arrestin2 Affects Cardiac Progenitor Cell Survival through Cell Mobility and Tube Formation in Severe Hypoxia. |
Search more.