Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.

scientific article published on 19 June 2013

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1038/LEU.2013.184
P932PMC publication ID3887408
P698PubMed publication ID23778311
P5875ResearchGate publication ID239947272

P50authorJames A. McCubreyQ42317570
Roberta MaestroQ55278822
Giuseppe MontaltoQ56806930
Ferdinando NicolettiQ84521195
Massimo LibraQ37842996
P2093author name stringF E Bertrand
A M Martelli
L Cocco
N M Davis
F Nicoletti
M Cervello
L S Steelman
S L Abrams
A B D'Assoro
J Basecke
P2860cites workBcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylationQ24298234
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-cateninQ24313571
Tankyrase inhibition stabilizes axin and antagonizes Wnt signallingQ24316697
GSK-3: tricks of the trade for a multi-tasking kinaseQ24624069
Regulation of myeloid leukaemia by the cell-fate determinant MusashiQ24634359
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signalingQ24673748
Wnt/β-catenin signaling and diseaseQ26823272
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia developmentQ26997109
The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear divisionQ27934794
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signalingQ28118465
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt familyQ28139153
Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathwaysQ28177635
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4Q28205234
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradationQ28208407
Wnt-5a has tumor suppressor activity in thyroid carcinomaQ28237192
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growthQ28262401
NUMB controls p53 tumour suppressor activityQ28263413
DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathwayQ28283034
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transductionQ28286117
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationQ28290083
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 betaQ28345704
Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancerQ28484291
Molecular cloning and expression of glycogen synthase kinase-3/factor AQ28569645
GSK-3-mediated phosphorylation enhances Maf-transforming activityQ28576703
A role for Wnt signalling in self-renewal of haematopoietic stem cellsQ28592213
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumorsQ28640916
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CMLQ29614278
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitorQ29614622
Wnt proteins are lipid-modified and can act as stem cell growth factorsQ29615009
WNT signalling pathways as therapeutic targets in cancerQ29615666
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancerQ29616163
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cellsQ29616552
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activationQ29618700
p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategiesQ37874926
Notch signaling in mammalian hematopoietic stem cellsQ37885708
Acquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycleQ37924479
GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer diseaseQ38020439
Involvement of glycogen synthase kinase-3β in arsenic trioxide-induced p21 expressionQ38337710
GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-MybQ38394964
Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.Q39344848
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequencyQ39357822
Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factorsQ39376795
Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtypeQ39380262
Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathwayQ39426971
The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activationQ39437383
Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts.Q39441263
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.Q39463725
Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cellsQ39468269
Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis.Q39472188
Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migrationQ39498392
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cellsQ39562043
Overexpression of glycogen synthase kinase-3 in ovarian carcinoma cells with acquired paclitaxel resistanceQ39570859
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.Q39590044
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cellsQ39620290
Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brainQ39657191
Inhibition of glycogen synthase kinase-3.Q39903047
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.Q39937420
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancerQ40012100
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell linesQ40125072
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.Q40350197
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation eventQ40624453
Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathwayQ40700367
The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP.Q40704880
Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signalingQ40866028
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.Q41290971
Glycogen synthase kinase-3 and cancer: good cop, bad cop?Q41331262
Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cellsQ41878659
Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.Q42140104
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.Q42723875
Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activationQ42809920
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenanceQ43195305
Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cellsQ43599325
Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2.Q43631715
Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradationQ43847013
PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic responseQ45038180
Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimidesQ46145961
t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanismQ46805127
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolismQ46972415
Activation of the Wnt signaling pathway: a molecular mechanism for lithium actionQ48958687
Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.Q49043307
Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and AxinQ50336867
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.Q50506558
Haematological effects of lithium carbonate: a study in 56 psychiatric patients.Q52100755
Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.Q52162599
Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15).Q53409042
Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells.Q54301591
Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1.Q54334679
Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation.Q54338655
GSK-3 inhibition in vitro and in vivo enhances antitumor effect of sorafenib in renal cell carcinoma (RCC).Q54505454
GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells.Q54571860
Glycogen Synthase Kinase-3 from Rabbit Skeletal MuscleQ56456617
Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cellsQ61041081
Increased number of peripheral blood CD34+ cells in lithium-treated patientsQ74122337
Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinaseQ77944438
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissueQ79358419
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenanceQ81308407
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-cateninQ81375017
Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cellsQ83289914
Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathwayQ84264128
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.Q35857078
CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamineQ35865075
Pharmaceutical inhibition of glycogen synthetase kinase-3β reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft modelQ35868347
Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cellsQ35900933
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myelomaQ35919057
β-Arrestin2 mediates the initiation and progression of myeloid leukemia.Q36140375
Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathwaysQ36457006
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivoQ36488720
Glycogen synthase kinase-3--an overview of an over-achieving protein kinaseQ36651778
γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-cateninQ36732802
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen speciesQ36916367
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.Q37001651
Dysregulated gene expression networks in human acute myelogenous leukemia stem cellsQ37097180
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generationQ37106907
Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degenerationQ37273048
Role of glycogen synthase kinase-3beta in cardioprotectionQ37303154
Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice.Q37452373
Glycogen synthase kinase 3 beta: can it be a target for oral cancerQ37764097
The medicinal chemistry of novel iron chelators for the treatment of cancer.Q37824720
Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signallingQ37856426
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Abnormalities in brain structure and behavior in GSK-3alpha mutant miceQ30485018
Failure of lithium to limit neutropenia significantly during induction therapy of acute myelogenous leukemia. A Southeastern Cancer Study Group study.Q33478283
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell deathQ33710200
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signalingQ33927142
Glycogen synthase kinase 3 is an insulin-regulated C/EBPalpha kinaseQ33960787
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheresQ34075159
GSK3 is a regulator of RAR-mediated differentiationQ34119834
NUMB-ing down cancer by more than just a NOTCH.Q34143037
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cellsQ34149498
Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation.Q34153063
The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemiaQ34156754
Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemiaQ34156762
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathwayQ34173253
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemiasQ34212654
Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers.Q34225338
Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinaseQ34251769
The Lkb1 metabolic sensor maintains haematopoietic stem cell survivalQ34568200
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signalingQ34574774
PML targeting eradicates quiescent leukaemia-initiating cellsQ34591761
Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulationQ34621025
Generation of multipotential mesendodermal progenitors from mouse embryonic stem cells via sustained Wnt pathway activationQ34665776
Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulationQ34905557
What Are the bona fide GSK3 Substrates?Q35001234
The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis.Q35026699
Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cellsQ35070240
Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory responseQ35108092
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in miceQ35187043
MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma.Q35256272
Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescenceQ35256323
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neuronsQ35563894
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferationQ35571394
Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activityQ35763147
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinibQ35774432
WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway.Q35840116
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitizationQ35857019
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectenzymeQ8047
armadillo domain proteinsQ4792547
leukemiaQ29496
peptideQ172847
transcription factorQ407384
hemopoiesisQ919283
carcinogenesisQ1637543
beta-cateninQ24783665
cytoskeletal proteinsQ66563066
macromolecular substanceQ75174158
Wnt proteinsQ77938923
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)15-33
P577publication date2013-06-19
2014-01-01
P1433published inLeukemiaQ6534498
P1476titleMultifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
P478volume28

Reverse relations

cites work (P2860)
Q37075360A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity
Q52668830A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase.
Q34483490A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer
Q89129402AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
Q99711172Activation of Type 4 Metabotropic Glutamate Receptor Regulates Proliferation and Neuronal Differentiation in a Cultured Rat Retinal Progenitor Cell Through the Suppression of the cAMP/PTEN/AKT Pathway
Q37589666Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes
Q51335065Aluminum Trichloride Inhibited Osteoblastic Proliferation and Downregulated the Wnt/β-Catenin Pathway.
Q42105697An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3β signaling in breast cancer cells
Q39247115Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis
Q39614255Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma
Q37108042CD147 modulates androgen receptor activity through the Akt/Gsk-3β/β-catenin/AR pathway in prostate cancer cells
Q28084610CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells
Q58697956CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression
Q41610540Characterization of the novel indolylmaleimides' PDA-66 and PDA-377 effect on canine lymphoma cells
Q99637584Cleavage of HSP90β induced by histone deacetylase inhibitor and proteasome inhibitor modulates cell growth and apoptosis
Q89896759Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo
Q38892306Combined inhibition of β-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo
Q59129152Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
Q40971143Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells
Q48157628Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin.
Q58617350Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML
Q49882954Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression
Q52668632Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Q35542173Expression and function of connexin 43 in human gingival wound healing and fibroblasts
Q90304508Extracellular vesicle-mediated crosstalk between NPCE cells and TM cells result in modulation of Wnt signalling pathway and ECM remodelling
Q41461266GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation
Q27013811GSK-3 as potential target for therapeutic intervention in cancer
Q38695750GSK-3β suppresses HCC cell dissociation in vitro by upregulating epithelial junction proteins and inhibiting Wnt/β-catenin signaling pathway
Q38716760Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.
Q37696169Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
Q33747040Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism
Q38272835Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
Q93034488Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses
Q41225033HDAC1 controls CIP2A transcription in human colorectal cancer cells
Q46652753High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor
Q37457938Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
Q51731135Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway.
Q37692593Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells
Q36022772Inhibition of β-Catenin to Overcome Endocrine Resistance in Tamoxifen-Resistant Breast Cancer Cell Line
Q26822956Keeping Wnt signalosome in check by vesicular traffic
Q37620821Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma
Q53644558Letter to the editor: An intriguing relationship between lipid droplets, cholesterol-binding protein CD133 and Wnt/β-catenin signaling pathway in carcinogenesis.
Q54263446Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent.
Q90048237Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer
Q46606963Neuroprotective Potential of Novel Multi-Targeted Isoalloxazine Derivatives in Rodent Models of Alzheimer's Disease Through Activation of Canonical Wnt/β-Catenin Signalling Pathway
Q46491430Niclosamide Prevents Systemic Sclerosis in a Reactive Oxygen Species-Induced Mouse Model.
Q38650702Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations
Q91844680Nucleolin promotes Wnt signaling in human hematopoietic stem/progenitor cells
Q61444792Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia
Q42378393Opposing roles of ICAT and Wnt/β-catenin signaling in NSC67657-induced monocytic differentiation
Q39008696Pharmacophore-based screening and drug repurposing exemplified on glycogen synthase kinase-3 inhibitors.
Q36324321Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients
Q54246485Porcine Circovirus-Like Virus P1 Inhibits Wnt Signaling Pathway in Vivo and in Vitro.
Q38829884Posttranslational modification of E-cadherin by core fucosylation regulates Src activation and induces epithelial-mesenchymal transition-like process in lung cancer cells
Q35081538Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease
Q39211921Potential role of Wnt/β-catenin signaling in blastic transformation of chronic myeloid leukemia: cross talk between β-catenin and BCR-ABL.
Q38696089Proinsulin Promotes Self-Renewal of a Hematopoietic Progenitor Cell Line In Vitro
Q92458728Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-catenin and AKT/GSK3β proliferative signaling
Q38885106Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood
Q28072650Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
Q58585886Rosmarinic Acid Derivatives' Inhibition of Glycogen Synthase Kinase-3β Is the Pharmacological Basis of Kangen-Karyu in Alzheimer's Disease
Q36205970SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML.
Q37662240ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3β/β-catenin signaling pathway
Q38431358Shikonin changes the lipopolysaccharide-induced expression of inflammation-related genes in macrophages
Q54345704Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/B preferentially within a protective bone marrow microenvironment.
Q54373992Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia.
Q28271278Survival regulation of leukemia stem cells
Q37058793The clinical significance of γ-catenin in acute myeloid leukemia
Q47237041The protective effect of PFTα on alcohol-induced osteonecrosis of the femoral head
Q52889828The tumor suppressive role of RASSF1A in osteosarcoma through the Wnt signaling pathway.
Q64061073Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer
Q39306017Wnt Signaling in Normal and Malignant Stem Cells
Q38411147Wnt3A Induces GSK-3β Phosphorylation and β-Catenin Accumulation Through RhoA/ROCK.
Q57801751miR-29s function as tumor suppressors in gliomas by targeting TRAF4 and predict patient prognosis
Q53120406microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia.
Q54117203β-arrestin2 Affects Cardiac Progenitor Cell Survival through Cell Mobility and Tube Formation in Severe Hypoxia.

Search more.