microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia.

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microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2016.127
P698PubMed publication ID27086927

P50authorJia YuQ82725342
Lei DongQ86611637
P2093author name stringL Li
J Wang
Y Zhu
F Li
Y Ma
H Zhao
F Wang
Y Ren
R Su
D Zou
P Yi
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Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1Q28508495
A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesisQ29619201
Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesisQ33464910
Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2Q33686871
Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiationQ33807659
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.Q34106870
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulationQ34212635
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemiaQ34307027
Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafishQ34380088
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Retroviral insertional activation of the Fli-3 locus in erythroleukemias encoding a cluster of microRNAs that convert Epo-induced differentiation to proliferationQ34640901
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Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiationQ34914457
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A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesisQ36769475
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Q37109227
A feedback loop consisting of microRNA 23a/27a and the β-like globin suppressors KLF3 and SP1 regulates globin gene expressionQ37264387
A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesisQ37416994
Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.Q37460101
JAK inhibitors suppress t(8;21) fusion protein-induced leukemiaQ37704373
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.Q39119297
HSP27 controls GATA-1 protein level during erythroid cell differentiationQ39712093
Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells.Q40493341
FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitorsQ40514439
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA bindingQ40850691
The erythroid leukemias: a comparative study of erythroleukemia (FAB M6) and Di Guglielmo diseaseQ41719761
MiR-181 family: regulators of myeloid differentiation and acute myeloid leukemia as well as potential therapeutic targetsQ41760459
Mutations and prognosis in primary myelofibrosisQ44429606
Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristicsQ44590610
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemiaQ45776985
GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiationQ47871799
Block of red blood cell maturation in acute erythroid leukemia.Q50501061
Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348).Q50860871
Ruxolitinib: the first FDA approved therapy for the treatment of myelofibrosis.Q53175859
The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells.Q54571865
MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia.Q54577287
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1Q73958442
Acute myeloid leukemia and the Wnt pathwayQ84423759
P433issue46
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
microRNAQ310899
P304page(s)6001-6014
P577publication date2016-04-18
P1433published inOncogeneQ1568657
P1476titlemicroRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia
P478volume35

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cites work (P2860)
Q52562647A step-by-step microRNA guide to cancer development and metastasis.
Q47719432Erythroleukemia-historical perspectives and recent advances in diagnosis and management
Q98611509Hippo/MST blocks breast cancer by downregulating WBP2 oncogene expression via miRNA processor Dicer
Q53141065MiR-615-5p depresses natural killer cells cytotoxicity through repressing IGF-1R in hepatocellular carcinoma patients.
Q99579036MicroRNA-23a acts as an oncogene in pancreatic carcinoma by targeting TFPI-2
Q47100599Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.
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Q37718379c-Myc suppresses miR-451⊣YWTAZ/AKT axis via recruiting HDAC3 in acute myeloid leukemia
Q90706419microRNA-23a in Human Cancer: Its Roles, Mechanisms and Therapeutic Relevance

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