Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system

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Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112E5169G
P356DOI10.1073/PNAS.1505512112
P932PMC publication ID4577147
P698PubMed publication ID26324895
P5875ResearchGate publication ID281520780

P50authorNicolas TaponQ39663297
P2093author name stringBirgit L Aerne
Ieva Gailite
P2860cites workThe brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.Q47072815
Anaplastic lymphoma kinase spares organ growth during nutrient restriction in DrosophilaQ48119750
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.Q52100108
Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.Q52663442
Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathwayQ81088455
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cellsQ24296824
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlQ24299106
Tumor suppressor LATS1 is a negative regulator of oncogene YAPQ24304725
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Q24310603
The AMPK signalling pathway coordinates cell growth, autophagy and metabolismQ24616273
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
The Hippo pathway effectors TAZ and YAP in development, homeostasis and diseaseQ26852353
Nutrient sensing, metabolism, and cell growth controlQ27024772
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatmentQ27025661
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lungQ28208680
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell linesQ28219379
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinaseQ28258611
The diverse functions of microRNAs in animal development and diseaseQ28266193
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPQ28266862
SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in DrosophilaQ28271058
Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)Q28287783
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinaseQ28301071
The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitorsQ28506288
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationQ28507317
YAP1 increases organ size and expands undifferentiated progenitor cellsQ28592519
LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrasesQ29615147
AMPK: a nutrient and energy sensor that maintains energy homeostasisQ29615410
The LKB1-AMPK pathway: metabolism and growth control in tumour suppressionQ29617506
Elucidation of a universal size-control mechanism in Drosophila and mammalsQ29618935
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosisQ29619851
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and wartsQ29620457
LKB1 modulates lung cancer differentiation and metastasisQ30080027
The Hippo-YAP signaling pathway and contact inhibition of growthQ30408095
Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblastsQ30577652
Context-dependent requirement for dE2F during oncogenic proliferationQ33373668
Somatic LKB1 mutations promote cervical cancer progressionQ33425903
Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferationQ33601460
Kibra is a regulator of the Salvador/Warts/Hippo signaling networkQ33754234
Hippo pathway activity influences liver cell fateQ34060093
The pattern of neuroblast formation, mitotic domains and proneural gene expression during early brain development in DrosophilaQ34210177
The Hippo tumor suppressor pathway regulates intestinal stem cell regenerationQ34342510
The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regenerationQ34342516
Hippo signaling regulatesDrosophilaintestine stem cell proliferation through multiple pathwaysQ34396983
The biology of YAP/TAZ: hippo signaling and beyondQ34442079
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 proteinQ34469155
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosisQ34474913
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarityQ34530696
Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepitheliaQ41268202
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in DrosophilaQ41717902
Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brainQ41874812
Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of YapQ42023045
Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell ProliferationQ42109247
Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.Q42625092
Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.Q42733015
Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasisQ42747736
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathwayQ44591663
The embryonic development of the Drosophila visual systemQ46181274
Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1.Q46689310
Early neurogenesis of the Drosophila brainQ46701102
The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior poleQ47071128
The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast divisionQ47071561
Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewalQ47071774
The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signalingQ47071805
Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT.Q47072231
JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in DrosophilaQ47072494
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.Q34546258
The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in DrosophilaQ34559232
The bantam microRNA is a target of the hippo tumor-suppressor pathwayQ34562924
Delineation of a Fat tumor suppressor pathwayQ34566699
Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skinQ34573137
P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.Q34586256
Drosophila neuroblasts: a model for stem cell biologyQ34645053
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblastsQ35221182
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathwayQ35236207
AMPK modulates Hippo pathway activity to regulate energy homeostasisQ35236353
Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobeQ35606421
Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brainsQ35650843
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogrammingQ35860353
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosisQ36336754
In vivo regulation of Yorkie phosphorylation and localization.Q36663448
LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.Q37211374
In vivo analysis of Yorkie phosphorylation sites.Q37239572
FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewalQ37308487
LKB1; linking cell structure and tumor suppressionQ37333592
A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesisQ37631216
Regulating neural proliferation in the Drosophila CNS.Q37676445
The Hippo size control pathway--ever expandingQ38077105
The Hippo pathway: regulators and regulationsQ38083640
The Hippo pathway and human cancer.Q38087215
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elementsQ38444916
LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of YapQ38632879
Immunohistochemical Loss of LKB1 Is a Biomarker for More Aggressive Biology in KRAS-Mutant Lung Adenocarcinoma.Q38903842
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.Q39041008
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.Q39221641
The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator YorkieQ39872336
YAP regulates neural progenitor cell number via the TEA domain transcription factorQ39915491
Energy-dependent regulation of cell structure by AMP-activated protein kinaseQ40135869
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.Q41073451
Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2.Q41135408
P4510describes a project that usesImageJQ1659584
P433issue37
P407language of work or nameEnglishQ1860
P304page(s)E5169-78
P577publication date2015-08-31
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDifferential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system
P478volume112

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cites work (P2860)
Q58695672A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
Q64067265Analysis of the role of the Hippo pathway in cancer
Q47132012Berberine and cinnamaldehyde together prevent lung carcinogenesis
Q50230833Calcitonin gene-related peptide-induced osteogenic differentiation of mouse bone marrow stromal cells through Hippo pathway in vitro
Q35970425Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila
Q47156481Circular RNAs: A Novel Player in Development and Disease of the Central Nervous System
Q92409363Endothelial Cell Mechano-Metabolomic Coupling to Disease States in the Lung Microvasculature
Q92320240Exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway
Q28269498Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
Q90131230Hippo signalling during development
Q64099741LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer
Q46087828LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism
Q26771285Mechanisms of Hippo pathway regulation
Q104069878Neuronal Hippo Signaling: From Development to Diseases
Q88229231Regulation of the Hippo pathway in cancer biology
Q95841422Tep1 Regulates Yki Activity in Neural Stem Cells in Drosophila Glioma Model
Q95645882The Hippo Pathway as a Driver of Select Human Cancers
Q50116622The Hippo pathway in organ development, homeostasis, and regeneration.
Q37689217The role of extracellular biophysical cues in modulating the Hippo-YAP pathway.
Q38864941YAP/TAZ at the Roots of Cancer.
Q90526067YAP/TAZ upstream signals and downstream responses
Q57802478Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
Q89595495Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation

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