Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase

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Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1084954791
P356DOI10.1038/SREP46751
P932PMC publication ID5402287
P698PubMed publication ID28436464

P50authorPeter OladimejiQ95985385
P2093author name stringTaosheng Chen
Wenwei Lin
Peter O Oladimeji
C Trent Brewer
P2860cites workThe blooming of the French lilacQ22241897
Role of AMP-activated protein kinase in mechanism of metformin actionQ22241898
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
The selectivity of protein kinase inhibitors: a further updateQ24654622
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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathwayQ28263744
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell lineQ28295835
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathwayQ28298223
LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
AMPK: a nutrient and energy sensor that maintains energy homeostasisQ29615410
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolismQ29617479
The LKB1-AMPK pathway: metabolism and growth control in tumour suppressionQ29617506
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?Q29618095
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energyQ29618101
Pharmacogenomics: translating functional genomics into rational therapeuticsQ33751829
A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathwayQ33945905
The specificities of small molecule inhibitors of the TGFß and BMP pathwaysQ33956096
Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probeQ34196976
First-pass elimination. Basic concepts and clinical consequencesQ34257205
Pregnane X Receptor and Constitutive Androstane Receptor at the Crossroads of Drug Metabolism and Energy MetabolismQ34359458
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanismQ34525699
Differential drug resistance acquisition to doxorubicin and paclitaxel in breast cancer cellsQ34787556
Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated ratsQ35131177
Dietary Effects on Drug Metabolism and TransportQ35553197
Differential effect of type I and type II diabetes on antipyrine disposition in manQ68466207
Hepatic drug metabolism is increased in poorly controlled insulin-dependent diabetes mellitusQ68628566
Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase CQ70733013
T0901317 is a potent PXR ligand: implications for the biology ascribed to LXRQ80120308
AMPK potentiates hypertonicity-induced apoptosis by suppressing NFκB/COX-2 in medullary interstitial cellsQ35758306
The camKK2/camKIV relay is an essential regulator of hepatic cancerQ35889308
Regulation of drug resistance by human pregnane X receptor in breast cancerQ36083299
Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinomaQ36213122
Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiologyQ36234679
Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancerQ36291183
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.Q36301403
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomesQ36661543
Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugsQ36795136
Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytesQ37014966
A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assayQ37303129
LKB1; linking cell structure and tumor suppressionQ37333592
The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolismQ37400616
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymesQ37493137
Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signalingQ37553490
P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humansQ37626608
The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agentQ37637656
Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyondQ38074718
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndromeQ38312576
AMPK: An Energy-Sensing Pathway with Multiple Inputs and OutputsQ38652124
Inhibition of pregnane X receptor pathway contributes to the cell growth inhibition and apoptosis of anticancer agents in ovarian cancer cellsQ38749288
AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation.Q38792676
Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.Q38879155
SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathwayQ38926671
Physicochemical characterization and in vitro permeation of an indirubin derivativeQ39101885
Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.Q39670303
Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cellsQ39941217
Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian cancer cells.Q40536091
A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B inductionQ42156016
ATP Consumption Promotes Cancer MetabolismQ42791522
Chemoprevention meets glucose controlQ42920178
5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner.Q42945903
Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat.Q43682845
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxificationQ44104285
Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptorQ44381593
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activitiesQ46563138
Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stressQ46868426
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)46751
P577publication date2017-04-24
P1433published inScientific ReportsQ2261792
P1476titleGlucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase
P478volume7

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cites work (P2860)
Q47166492Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450.
Q50122109High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor
Q89455144KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion
Q91272344Nutritional status modifies pregnane X receptor regulated transcriptome
Q90281157The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis
Q88669494The Roles of Xenobiotic Receptors: Beyond Chemical Disposition
Q50056522Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction

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