Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes

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Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes is …
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scholarly articleQ13442814

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P356DOI10.3748/WJG.V22.I1.300
P3181OpenCitations bibliographic resource ID4911071
P932PMC publication ID4698494
P698PubMed publication ID26755878
P5875ResearchGate publication ID288855721

P50authorYuan-Chi TengQ87057418
P2093author name stringTing-Fen Tsai
Cheng-Heng Kao
Zhao-Qing Shen
P2860cites workHeterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.Q43739403
Characterizing antiviral activity of adefovir dipivoxil in transgenic mice expressing hepatitis B virusQ44036705
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virusQ21128797
Hallmarks of Cancer: The Next GenerationQ22252312
Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinomaQ24290300
CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinantQ24290613
Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signallingQ24307907
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationQ24310189
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressorQ24569647
New advances in precision medicine for hepatocellular carcinoma recurrence prediction and treatmentQ87416815
Chromosomal instability and cancer: a complex relationship with therapeutic potentialQ24608609
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneQ24617547
Downregulation of miR-122 in the rodent and human hepatocellular carcinomasQ24631076
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesisQ24632905
The interaction of hepatic lipid and glucose metabolism in liver diseasesQ26827770
S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utilityQ26829356
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisQ26853207
Targeting the ubiquitin pathway for cancer treatmentQ26866185
SOCS, inflammation, and cancerQ26991808
Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancerQ26992106
Autophagy in malignant transformation and cancer progressionQ27000191
Mouse models of hepatitis B virus infection comprising host-virus immunologic interactionsQ27002598
Persistent hepatitis B viral replication in a FVB/N mouse model: impact of host and viral factorsQ27302970
p53, the cellular gatekeeper for growth and divisionQ27860990
Nrf1 is critical for redox balance and survival of liver cells during developmentQ28179361
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130Q28211408
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasiaQ28237402
Clinical significance of increased expression of Nijmegen breakage syndrome gene (NBS1) in human primary liver cancerQ28265438
Genomic instability--an evolving hallmark of cancerQ28274009
Minireview: PRKAR1A: normal and abnormal functionsQ28279040
Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinomaQ28284012
Tumor suppressor and hepatocellular carcinomaQ28389231
Pten is essential for embryonic development and tumour suppressionQ28509238
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinomaQ28586911
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liverQ28587974
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient miceQ28588080
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppressionQ28591557
Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomasQ28592004
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's diseaseQ28592482
Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesisQ28594255
Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic miceQ28776764
Autophagy regulates lipid metabolismQ29547421
The role of autophagy during the early neonatal starvation periodQ29547489
WNT signalling pathways as therapeutic targets in cancerQ29615666
Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancerQ35581153
Noncoding RNA as therapeutic targets for hepatocellular carcinoma.Q35592207
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null miceQ35765708
NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinomaQ35808323
PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesisQ35832384
Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesisQ35834086
High-level hepatitis B virus replication in transgenic miceQ35847850
Interleukin-12 inhibits hepatitis B virus replication in transgenic miceQ35881471
Targeting the interleukin-6/Jak/stat pathway in human malignanciesQ35925127
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinomaQ35945177
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expressionQ35970148
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.Q35991536
Sak/Plk4 and mitotic fidelityQ36004665
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesisQ36129123
Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicingQ36141301
Tumor suppressor geneticsQ36252762
Tumor development: haploinsufficiency and local network assemblyQ36285535
HBV induced carcinogenesisQ36388400
Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death inductionQ36389447
Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegansQ36389497
Immune pathogenesis of hepatocellular carcinoma.Q36401448
SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesisQ36402678
Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.Q36497062
Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesisQ36519025
Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesisQ36545096
TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in miceQ36633583
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in miceQ36688699
Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouseQ36701660
Hepatitis B virus transactivator X protein is not tumorigenic in transgenic miceQ36796019
Tissue preferential expression of the hepatitis B virus (HBV) surface antigen gene in two lines of HBV transgenic miceQ36827049
Developmental regulation of hepatitis B surface antigen expression in two lines of hepatitis B virus transgenic miceQ36830784
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic miceQ36869563
Hepatic stem cells and transforming growth factor β in hepatocellular carcinomaQ37099380
Viral hepatocarcinogenesis: from infection to cancerQ34587991
Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic miceQ34599361
Genetic mechanisms of hepatocarcinogenesisQ34611410
Hepatocellular carcinoma: insight from animal modelsQ34633249
MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches.Q34675280
Tumor suppressor gene-based nanotherapy: from test tube to the clinicQ34730883
Targeting Hepatitis B Virus With CRISPR/Cas9.Q34745348
Regulatory elements of hepatitis B virus transcriptionQ34842064
Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224.Q34984034
The regulation of inflammation by galectin-3.Q34991925
Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children.Q35000423
Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stabilityQ35026390
Overexpression of TRIM24 is associated with the onset and progress of human hepatocellular carcinomaQ35084843
NF-κB addiction and its role in cancer: 'one size does not fit all'.Q35120893
Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.Q35131908
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cellsQ35208410
Sgo1 is a potential therapeutic target for hepatocellular carcinomaQ35273343
NF-κB and STAT3 - key players in liver inflammation and cancerQ35347976
Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient miceQ35356022
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomasQ35379075
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinomaQ37138658
Tenets of PTEN tumor suppressionQ37154214
Pivotal role of mTOR signaling in hepatocellular carcinomaQ37183244
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinomaQ37284612
LKB1; linking cell structure and tumor suppressionQ37333592
Role of bile acids and bile acid receptors in metabolic regulationQ37363616
APC promoter methylation and protein expression in hepatocellular carcinomaQ37376713
CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processesQ37448141
Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient miceQ37557334
Then and now: the progress in hepatitis B treatment over the past 20 yearsQ37581346
TGF-β: duality of function between tumor prevention and carcinogenesis.Q37634488
Identification of novel oncogenes and tumor suppressors in hepatocellular carcinomaQ37696402
The role of signaling pathways in the development and treatment of hepatocellular carcinomaQ37773788
Autophagy in liver diseases.Q37784560
Haplo-insufficiency: a driving force in cancerQ37815124
Biology of Krüppel-like factor 6 transcriptional regulator in cell life and deathQ37820607
Switching TGFβ from a tumor suppressor to a tumor promoter.Q37830876
Hepatitis B therapyQ37855531
Genetics of hepatobiliary carcinogenesisQ37871482
Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): an emerging field for advanced technologies.Q37904165
Bile acids: from digestion to cancersQ38024178
gp78: a multifaceted ubiquitin ligase that integrates a unique protein degradation pathway from the endoplasmic reticulumQ38027564
Bile acid transporters and regulatory nuclear receptors in the liver and beyondQ38033967
p21WAF1 and tumourigenesis: 20 years afterQ38060451
S-adenosylmethionine metabolism and liver disease.Q38080431
Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistanceQ38081267
The mTOR pathway in hepatic malignanciesQ38081396
The role of autophagy in liver cancer: molecular mechanisms and potential therapeutic targetsQ38083383
Mouse models for liver cancer.Q38083387
Potential role of annexin A7 in cancersQ38103681
An Overview of Hepatitis B Virus Surface Antigen Mutant in the Asia PacificQ38135400
Mice with human liversQ38138332
Krüppel-like factors in cancerQ38141516
An emerging role of PARK2 in cancerQ38168127
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathwayQ38170894
The role and therapeutic implications of RING-finger E3 ubiquitin ligases in hepatocellular carcinomaQ38178169
Molecular insights into NF2/Merlin tumor suppressor functionQ38204110
Caught up in a Wnt storm: Wnt signaling in cancerQ29617494
Epidemiology of viral hepatitis and hepatocellular carcinomaQ29617918
Immunology of hepatitis B virus and hepatitis C virus infectionQ29618957
The Hippo signaling pathway in stem cell biology and cancerQ30410176
Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinomaQ32100816
Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouseQ33194830
Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinomaQ33601430
Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.Q33632161
Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?Q33762446
In vivo regulation of hepatitis B virus replication by peroxisome proliferatorsQ33825523
Expression and replication of hepatitis B virus genome in transgenic miceQ33828858
Nuclear covalently closed circular viral genomic DNA in the liver of hepatocyte nuclear factor 1 alpha-null hepatitis B virus transgenic miceQ33865967
Role of Wnt/β-catenin signaling in liver metabolism and cancerQ33940403
Late mitotic failure in mice lacking Sak, a polo-like kinase.Q33942360
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liverQ34069370
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammalsQ34077795
Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagyQ34086698
The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceQ34173242
The ubiquitin-proteasome system: opportunities for therapeutic intervention in solid tumorsQ34218976
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genesQ34274999
MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression.Q34294469
Complex interactions between microRNAs and hepatitis B/C virusesQ34302987
S-adenosylmethionine in liver health, injury, and cancerQ34306534
Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice.Q34350113
Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic miceQ34350664
The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis.Q34354947
Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinomaQ34359262
NAFLD, NASH and liver cancerQ34374372
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomasQ34380511
Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesisQ34388829
Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma.Q34396410
The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In VivoQ34459390
Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA levelQ34481474
Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout miceQ34526330
Hippo-YAP signaling pathway: A new paradigm for cancer therapyQ38231786
Hepatocellular carcinoma epidemiologyQ38254688
Hippo pathway regulation of gastrointestinal tissuesQ38257899
Hepatocellular carcinoma and microRNA: new perspectives on therapeutics and diagnosticsQ38275679
Shugoshins: tension-sensitive pericentromeric adaptors safeguarding chromosome segregationQ38276217
Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.Q38310253
The JAK-STAT pathway: impact on human disease and therapeutic interventionQ38317993
Identification of the common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model.Q38330894
Hitting cancers' weak spots: vulnerabilities imposed by p53 mutationQ38470609
Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-proteinQ38527672
miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditionsQ39364639
The molecular biology of the hepatitis B virusesQ39511089
Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinomaQ39916459
Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activationQ40124427
Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genomeQ40130886
Reduced expression of CYLD in human colon and hepatocellular carcinomasQ40267883
Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes.Q40455477
Parkin gene alterations in hepatocellular carcinomaQ40564245
A transgenic mouse model of the chronic hepatitis B surface antigen carrier stateQ41483768
A biphasic response pattern of lipid metabolomics in the stage progression of hepatitis B virus X tumorigenesisQ41540811
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonucleaseQ41566723
Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic miceQ41736950
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic miceQ41757834
Autophagy-deficient mice develop multiple liver tumorsQ42099409
A quantitative proteomic approach for identification of potential biomarkers in hepatocellular carcinomaQ42594913
Resveratrol helps recovery from fatty liver and protects against hepatocellular carcinoma induced by hepatitis B virus X protein in a mouse modelQ42717718
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibitionQ42718504
Parkin as a tumor suppressor gene for hepatocellular carcinomaQ42811415
Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinomaQ43049041
Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic miceQ43601327
Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic miceQ44184480
Thirty-year outcomes of the national hepatitis B immunization program in TaiwanQ44712948
Production and effect of infectious Dane particles in transgenic miceQ44984147
Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic miceQ45420975
The hepatitis B virus-trimera mouse: a model for human HBV infection and evaluation of anti-HBV therapeutic agents.Q45751631
High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic miceQ45779177
Hepatic preneoplasia in hepatitis B virus transgenic miceQ45782995
HBx gene of hepatitis B virus induces liver cancer in transgenic miceQ45852802
Characterization of T-cell tolerance to hepatitis B virus (HBV) antigen in transgenic miceQ45868334
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophagesQ46376203
Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinomaQ46442908
Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan.Q46573520
Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic miceQ46702642
Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.Q47852627
Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolismQ47982118
Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.Q51323736
Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice.Q52574179
Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.Q52621794
p21 ablation in liver enhances DNA damage, cholestasis, and carcinogenesis.Q53224670
TRIM proteins and cancer.Q53280723
TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.Q53299056
Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice.Q53319230
Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.Q53344106
Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.Q53356205
HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice.Q53370903
p21Cip1 nullizygosity increases tumor metastasis in irradiated mice.Q53378608
Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role.Q53631902
Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.Q54305213
Hepatobiliary transporter expression in human hepatocellular carcinoma.Q54674953
Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma.Q54695730
Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice.Q54727263
Mutational and expressional analyses of ATG5, an autophagy-related gene, in gastrointestinal cancers.Q55054516
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular CarcinomaQ58619568
Sh(i)pping signals protect against Stat3-driven liver cancerQ59198940
Specific expression of hepatitis B surface antigen (HBsAg) in transgenic miceQ59890897
Sh(i)pping signals protect against Stat3-driven liver cancerQ62176883
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinomaQ62727088
HBV production in transgenic miceQ68582773
Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic miceQ72712084
Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: clinicopathologic correlation and survival analysisQ74421318
Molecular pathogenesis of human hepatocellular carcinomaQ74543031
Transforming growth factor betas and their signaling receptors in human hepatocellular carcinomaQ77373481
Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomasQ77554578
ANXA7 expression represents hormone-relevant tumor suppression in different cancersQ80817271
NEMO expression in human hepatocellular carcinoma and its association with clinical outcomeQ82999544
Genomic instability and cancer: an introductionQ83325039
The cell cycle and cancerQ85077091
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthaploinsufficiencyQ852654
hepatocellular carcinomaQ1148337
Hepatitis B virusQ6844
virologyQ7215
P304page(s)300-325
P577publication date2016-01-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleHepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes
P478volume22

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