Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition

scientific article published on 5 June 2014

Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CMET.2014.05.001
P932PMC publication ID4079758
P698PubMed publication ID24910242
P5875ResearchGate publication ID262942777

P50authorMichael KarinQ1458081
Mark A ValasekQ59557458
Hayato NakagawaQ80174875
P2093author name stringMichael N Hall
Ekihiro Seki
Koji Taniguchi
Jun Hee Lee
Atsushi Umemura
Mariam Aghajan
Eek Joong Park
Shabnam Shalapour
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Profiling sirolimus-induced inflammatory syndrome: a prospective tricentric observational studyQ28484885
Autophagy regulates lipid metabolismQ29547421
Ras, PI(3)K and mTOR signalling controls tumour cell growthQ29614734
Activation of a metabolic gene regulatory network downstream of mTOR complex 1Q29615179
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expressionQ29615766
mTOR and cancer: insights into a complex relationshipQ29617779
Rapamycin extends murine lifespan but has limited effects on agingQ30541884
The yeast Tor signaling pathway is involved in G2/M transition via polo-kinaseQ33336423
Raptor is phosphorylated by cdc2 during mitosisQ33532654
Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signalingQ33588191
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activationQ33737707
Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathyQ34340407
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophyQ34891582
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.Q35572388
High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1.Q35694634
Phase 1/2 study of everolimus in advanced hepatocellular carcinomaQ36160273
Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerationsQ36742629
The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapyQ36838789
Targeting the mTOR signaling network in cancer.Q36955694
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.Q37094456
Common corruption of the mTOR signaling network in human tumorsQ37643431
Evolving strategies for the treatment of hepatocellular carcinoma: from clinical-guided to molecularly-tailored therapeutic options.Q37783666
Rapamycin passes the torch: a new generation of mTOR inhibitorsQ37950771
mTOR in aging, metabolism, and cancerQ38073906
The mTOR pathway in hepatic malignanciesQ38081396
Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.Q38123696
Review of combination therapy with mTOR inhibitors and tacrolimus minimization after transplantationQ38127967
Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma - systematic review and meta-analysisQ38176862
Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translationQ39707997
47 Liver cellsQ41460095
Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinomaQ43049041
AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expressionQ44009527
Rapamycin unbalances the polarization of human macrophages to M1.Q45057583
The TSC-mTOR signaling pathway regulates the innate inflammatory responseQ46321173
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesisQ46576855
Reducing the load: the evolution and management of obesity and nonalcoholic steatohepatitis before liver transplantationQ48232083
Evaluation of rapamycin-induced cell death.Q54546876
The use of sirolimus should be restricted in liver transplantationQ84529512
P433issue1
P304page(s)133-144
P577publication date2014-06-05
P1433published inCell MetabolismQ1254684
P1476titleLiver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition
P478volume20

Reverse relations

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