Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome

scientific article published on February 2001

Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/JCP.54.2.126
P932PMC publication ID1731344
P698PubMed publication ID11215281
P5875ResearchGate publication ID274442897

P2093author name stringde Goeij AF
Wilson JH
van Velthuysen ML
Offerhaus GJ
Giardiello FM
Entius MM
Westerman AM
van Rees BP
Keller JJ
P2860cites workLoss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneityQ24539769
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancersQ24671334
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
Lessons from hereditary colorectal cancerQ28131788
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers familiesQ28139857
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinaseQ28258611
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancerQ28267211
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysisQ28300857
Peutz-Jeghers syndrome: 78-year follow-up of the original familyQ33601730
The molecular basis and clinical aspects of Peutz-Jeghers syndromeQ33667996
Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.Q33680045
Increased risk for cancer in patients with the Peutz-Jeghers syndromeQ34472625
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrestQ34504424
Cancer and the Peutz-Jeghers syndromeQ34532616
Increased risk of cancer in the Peutz-Jeghers syndromeQ34690977
Peutz-Jeghers syndrome: confirmation of linkage to chromosome 19p13.3 and identification of a potential second locus, on 19q13.4.Q34743858
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumorsQ34747457
Mutations of the STK11 gene in sporadic gastric carcinoma.Q34749868
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.Q34754689
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.Q34755744
LKB1 somatic mutations in sporadic tumorsQ35793276
An Alu polymorphism intragenic to the TP53 geneQ35802335
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridizationQ35833155
Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.Q35833930
Optimizing the APC gene mutation analysis in archival colorectal tumor tissueQ38467952
An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasmsQ38484544
Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine (Peutz-Jeghers syndrome): report of a case and review of the literatureQ40339269
Phenotype and cancer risk of various polyposis syndromesQ40423628
Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutationsQ42142322
Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivationQ42791516
Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromesQ42850964
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC geneQ45345254
Molecular diagnosis of familial adenomatous polyposis.Q54646463
Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and DigitsQ57073474
A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic mapQ57337215
Potential false-positive results with antigen enhancement for immunohistochemistry of the p53 gene product in colorectal neoplasmsQ71459182
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)126-131
P577publication date2001-02-01
P1433published inJournal of Clinical PathologyQ6294965
P1476titleMolecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome
P478volume54

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cites work (P2860)
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