Molecular mechanism of action of metformin: old or new insights?

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Molecular mechanism of action of metformin: old or new insights? is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1037508442
P356DOI10.1007/S00125-013-2991-0
P8608Fatcat IDrelease_rerxv7tsxnf3jdt232wfgkeoyi
P3181OpenCitations bibliographic resource ID88169
P932PMC publication ID3737434
P698PubMed publication ID23835523
P5875ResearchGate publication ID247771646

P50authorEwan PearsonQ56240082
Graham RenaQ72997557
P2093author name stringKei Sakamoto
P2860cites workMetformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 DiabetesQ22241283
The blooming of the French lilacQ22241897
Role of AMP-activated protein kinase in mechanism of metformin actionQ22241898
MetforminQ22250907
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMPQ22251081
Risk of Fatal and Nonfatal Lactic Acidosis With Metformin Use in Type 2 Diabetes MellitusQ22253064
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitusQ24235718
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitusQ24244739
The selectivity of protein kinase inhibitors: a further updateQ24654622
Cellular and molecular mechanisms of metformin: an overviewQ27013561
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout miceQ28510615
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminQ28590162
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) GroupQ29547282
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chainQ29615210
AMPK: a nutrient and energy sensor that maintains energy homeostasisQ29615410
Metformin and reduced risk of cancer in diabetic patientsQ29616275
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismQ29617261
The specificities of small molecule inhibitors of the TGFß and BMP pathwaysQ33956096
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy stateQ33968008
Glucose-lowering agents and the patterns of risk for cancer: a study with the General Practice Research Database and secondary care data.Q34086275
CREB and the CRTC co-activators: sensors for hormonal and metabolic signalsQ34166530
Effects of guanidine derivatives on mitochondrial function. I. Phenethylbiguanide inhibition of respiration in mitochondria from guinea pig and rat tissuesQ34279634
Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokineticsQ34292544
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.Q34506457
LKB1-dependent signaling pathwaysQ34535140
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetesQ34539510
Calcium-like Action of Phenethylbiguanide and Related Compounds: Inhibition of Pyruvate KinaseQ34718181
Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of DiabetesQ34862358
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin actionQ35762110
The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic reviewQ35800117
Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysisQ35842470
Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance.Q35849360
Cellular responses to the metal-binding properties of metformin.Q35976604
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.Q36013520
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cellsQ36016832
AMP-activated protein kinase as a drug target.Q36551887
Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implicationsQ36808739
Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS studyQ37193773
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetesQ37319178
Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic controlQ37621774
An energetic tale of AMPK-independent effects of metformin.Q37767575
Hormonal regulation of hepatic glucose production in health and diseaseQ37896899
The alpha-cell as target for type 2 diabetes therapy.Q37977335
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.Q38298758
Effects of guanidine derivatives on mitochondrial function. 3. The mechanism of phenethylbiguanide accumulation and its relationship to in vitro respiratory inhibition.Q38362681
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activationQ39697365
Lactic acidosis in biguanide-treated diabetics: a review of 330 casesQ39718414
Guanidine Derivatives in MedicineQ39927463
Tailoring cAMP-signalling responses through isoform multiplicityQ41516369
Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cellsQ41604474
Evidence that the flux control coefficient of the respiratory chain is high during gluconeogenesis from lactate in hepatocytes from starved rats. Implications for the hormonal control of gluconeogenesis and action of hypoglycaemic agentsQ41849151
Inhibitory effects of metformin on insulin and glucagon action in rat hepatocytes involve post-receptor alterationsQ42517708
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cellsQ44468960
Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?Q44816749
Regeneration of the heart in diabetes by selective copper chelationQ45032429
Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population-based studyQ45389552
A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: a randomised placebo-controlled studyQ46145344
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.Q46236023
Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements inQ46458763
Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cellsQ46523954
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
Marked Hyperlipidemia and Pancreatitis Associated with Oral Contraceptive TherapyQ47981050
The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.Q50510276
Effects of metformin on glucose and glucagon regulated gluconeogenesis in cultured normal and diabetic hepatocytes.Q51594182
über Synthetisch Dargestellte Körper mit Insulinartiger Wirkung Auf den Normalen und Diabetischen OrganismusQ56444436
Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)Q57412648
Metformin treatment of lean and obese Zucker rats modulates the ability of glucagon and insulin to regulate hepatocyte adenylate cyclase activityQ57910695
Specific Inhibition of Gluconeogenesis by BiguanidesQ58982690
BiguanidesQ67291826
On the mechanism of action of hypoglycemia-producing biguanides. A reevaluation and a molecular theoryQ67851216
Mode of action of hypoglycemic agents. V. Studies with phenethylbiguanide in isolated perfused rat liverQ69637534
Effect of metformin on glucose metabolism in mouse soleus muscleQ69640883
The interaction of fructose 2,6-bisphosphate and AMP with rat hepatic fructose 1,6-bisphosphataseQ71245975
Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose productionQ72020678
Accumulation of metformin by tissues of the normal and diabetic mouseQ72381698
Inhibition of electron and energy transfer in mitochondria. II. The site and the mechanism of guanidine actionQ76463507
The relation of synthalin to carbohydrate metabolismQ80326312
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P275copyright licenseCreative Commons Attribution-NonCommercial 2.0 GenericQ44128984
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
amidinesQ423088
P304page(s)1898-1906
P577publication date2013-07-09
P1433published inDiabetologiaQ5270140
P1476titleMolecular mechanism of action of metformin: old or new insights?
P478volume56

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cites work (P2860)
Q90192600A Cohort Study of Exposure to Antihyperglycemic Therapy and Survival in Patients with Lung Cancer
Q37005064A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding
Q64232987A Novel Dipeptide NGF Mimetic GK-2 Selectively Activating the PI3K/AKT Signaling Pathway Promotes the Survival of Pancreatic β-Cells in a Rat Model of Diabetes
Q51281697A novel polymorphism in protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) is associated with type 2 diabetes in the Han Chinese population.
Q47240106A reappraisal on metformin
Q94526301A review of cancer immunotherapy: from the past, to the present, to the future
Q54365047A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.
Q35859585AMP-activated Protein Kinase Suppresses Biosynthesis of Glucosylceramide by Reducing Intracellular Sugar Nucleotides
Q92601237AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells
Q33824564AMPK activation: a therapeutic target for type 2 diabetes?
Q57170002AMPK: Potential Therapeutic Target for Ischemic Stroke
Q43809926Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial
Q38734414Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells
Q37692552Adipokines and insulin action: A sensitive issue
Q90221587Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease
Q90478040Advanced and multifaceted stability profiling of the first-line antidiabetic drugs metformin, gliclazide and glipizide under various controlled stress conditions
Q40296763Aging metabolism: intervention strategies
Q34003050An update on the pharmacogenomics of metformin: progress, problems and potential
Q37187900Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Q57281750Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial-mesenchymal transition in human colon cancer cells
Q40251170Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes
Q35675566Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.
Q91597975Back to basics with active lifestyles: exercise is more effective than metformin to reduce cardiovascular risk in older adults with type 2 diabetes
Q28541332Berberine promotes glucose consumption independently of AMP-activated protein kinase activation
Q64941870Bidirectional regulation of adenosine 5'-monophosphate-activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration.
Q65002446Capsaicin Analogues Derived from n-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro.
Q42372108Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats
Q34383575Cardiovascular impact of drugs used in the treatment of diabetes
Q36520595Case-control study of oral glucose-lowering drugs in combination with long-acting insulin and the risks of incident myocardial infarction and incident stroke
Q38147723Clinical relevance of target identity and biology: implications for drug discovery and development
Q38945649Combatting type 2 diabetes by turning up the heat
Q33605925Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis
Q35800392Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth.
Q26740253Common medications used by patients with type 2 diabetes mellitus: what are their effects on the lipid profile?
Q47817158Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial
Q30373454Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration.
Q26778957Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1
Q36427543Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass
Q47144635Dual Therapy Appears Superior to Monotherapy for Low-Income Individuals With Newly Diagnosed Type 2 Diabetes.
Q35535310Effect comparison of metformin with insulin treatment for gestational diabetes: a meta-analysis based on RCTs
Q38948037Effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus and inadequate glycemic control
Q48089757Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats.
Q35944675Effects of caloric restriction and low glycemic index diets associated with metformin on glucose metabolism and cortisol response in overweight/obese subjects: a case series study.
Q27003253Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain
Q45718198Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial.
Q37629041Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.
Q40989059Epithelial-Mesenchymal Transition Phenotype, Metformin, and Survival for Colorectal Cancer Patients with Diabetes Mellitus II.
Q38607553Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes.
Q48042047Functional interplay between LXR and AMPKα inhibits atherosclerosis in apoE deficient mice - A new anti-atherogenic strategy.
Q53411897Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes.
Q89462733Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice
Q36253720Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.
Q91991851Gut microbiome differences between metformin- and liraglutide-treated T2DM subjects
Q35725065Gut microorganisms as promising targets for the management of type 2 diabetes
Q44655644Head and neck cancers, the neglected malignancies: present and future treatment strategies
Q57180762Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology
Q36016417Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target
Q34989872Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats
Q35935123Interventions to Slow Aging in Humans: Are We Ready?
Q28829020Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug
Q35685308Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice
Q47252413Lean Body Weight and Metformin Are Insufficient to Prevent Endometrial Hyperplasia in Mice Harboring Inactivating Mutations in PTEN.
Q53706040Meta- and cross-species analyses of insulin resistance based on gene expression datasets in human white adipose tissues.
Q39318607Metabolic Alterations at the Crossroad of Aging and Oncogenesis
Q51533022Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer's Disease.
Q37314264Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus
Q91854786Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level
Q58723952Metformin added to bosentan therapy in patients with pulmonary arterial hypertension associated with congenital heart defects: a pilot study
Q35853068Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
Q35858703Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway
Q28082736Metformin and metabolic diseases: a focus on hepatic aspects
Q61801352Metformin and the Risk of Dementia in Type 2 Diabetes Patients
Q34151605Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis
Q41038714Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state
Q42256796Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity.
Q53692797Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age.
Q28539104Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells
Q49180657Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells
Q64105328Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts
Q34505650Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium
Q38834937Metformin prevents DMH-induced colorectal cancer in diabetic rats by reversing the warburg effect
Q47297378Metformin prevents ischaemic ventricular fibrillation in metabolically normal pigs
Q55342484Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism.
Q59882737Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
Q98386080Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells
Q42362632Metformin selectively targets redox control of complex I energy transduction
Q37364089Metformin treatment of antipsychotic-induced dyslipidemia: an analysis of two randomized, placebo-controlled trials
Q36103093Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer
Q35046673Metformin use and lung cancer risk in patients with diabetes.
Q40930334Metformin use improves the survival of diabetic combined small-cell lung cancer patients
Q92383575Metformin use is associated with a lower risk of uterine leiomyoma in female type 2 diabetes patients
Q97643486Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss
Q26999344Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium
Q43576506Metformin: an old drug with new potential
Q41866726Mulberry leaf alleviates streptozotocin-induced diabetic rats by attenuating NEFA signaling and modulating intestinal microflora
Q40949691NHX-5, an Endosomal Na+/H+ Exchanger, Is Associated with Metformin Action.
Q92538820NK Cell Metabolism and TGFβ - Implications for Immunotherapy
Q47551363Negative Effects of Chronic Rapamycin Treatment on Behavior in a Mouse Model of Fragile X Syndrome.
Q26786307Neuropharmacological Actions of Metformin in Stroke
Q41669655New Evidence for the Mechanism of Action of a Type-2 Diabetes Drug Using a Magnetic Bead-Based Automated Biosensing Platform
Q33838229Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus.
Q38374396Novel therapeutic targets of metformin: metabolic syndrome and cardiovascular disease
Q37673171Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.
Q54946332Obesity as disruptor of the female fertility.
Q53723216Oxamate Enhances the Anti-Inflammatory and Insulin-Sensitizing Effects of Metformin in Diabetic Mice.
Q38747416Pharmacogenetics in type 2 diabetes: precision medicine or discovery tool?
Q38816602Pharmacogenetics: Implications for Modern Type 2 Diabetes Therapy
Q49850150Pharmacokinetics of metformin in patients with gastrointestinal intolerance
Q92031590Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine
Q41428466Predicting Clostridium difficile infection in diabetic patients and the effect of metformin therapy: a retrospective, case-control study
Q34776628Prenatal metformin exposure in a maternal high fat diet mouse model alters the transcriptome and modifies the metabolic responses of the offspring.
Q93038010Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice
Q40847551Prognosis of small cell lung cancer patients with diabetes treated with metformin
Q39814876Re-sensitization of radiation resistant colorectal cancer cells to radiation through inhibition of AMPK pathway
Q90312494Recent Advances in Anti-Aging Medicine
Q33616159Recent progress in metabolic signaling pathways regulating aging and life span
Q36800163Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance
Q42775670Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation
Q89371436Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)
Q58739088Repurposing of Drugs Targeting YAP-TEAD Functions
Q38225855Revisiting "Vegetables" to combat modern epidemic of imbalanced glucose homeostasis
Q38800502Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells.
Q54382901Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury.
Q41021948Salicylic acid: old and new implications for the treatment of type 2 diabetes?
Q51439096Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling.
Q92128838Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
Q26865663Something old, something new and something very old: drugs for treating type 2 diabetes
Q85487123Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation
Q35153493Survival of patients with stage IV lung cancer with diabetes treated with metformin
Q97539453T Cell Metabolism in Cancer Immunotherapy
Q52661722Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy.
Q38586248The Bidirectional Relationship between Metabolism and Immune Responses
Q40842440The Effect of Metformin Use on Left Ventricular Ejection Fraction and Mortality Post-Myocardial Infarction
Q34086454The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
Q89862360The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach
Q57086835The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration
Q38996030The emerging role of metformin in gestational diabetes mellitus
Q33804241The role of genetic factors and kidney and liver function in glycemic control in type 2 diabetes patients on long-term metformin and sulphonylurea cotreatment
Q35880380Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill"
Q35761723Therapeutic Concentrations of Metformin: A Systematic Review
Q38823805Therapeutic Potential of Antidiabetic Medications in the Treatment of Cognitive Dysfunction and Dementia
Q33787067To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents
Q39630588Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome.
Q44510337Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress
Q30240030Understanding and overcoming metformin gastrointestinal intolerance.
Q54976706Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART.

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