review article | Q7318358 |
scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1037508442 |
P356 | DOI | 10.1007/S00125-013-2991-0 |
P8608 | Fatcat ID | release_rerxv7tsxnf3jdt232wfgkeoyi |
P3181 | OpenCitations bibliographic resource ID | 88169 |
P932 | PMC publication ID | 3737434 |
P698 | PubMed publication ID | 23835523 |
P5875 | ResearchGate publication ID | 247771646 |
P50 | author | Ewan Pearson | Q56240082 |
Graham Rena | Q72997557 | ||
P2093 | author name string | Kei Sakamoto | |
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Inhibitory effects of metformin on insulin and glucagon action in rat hepatocytes involve post-receptor alterations | Q42517708 | ||
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells | Q44468960 | ||
Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? | Q44816749 | ||
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On the mechanism of action of hypoglycemia-producing biguanides. A reevaluation and a molecular theory | Q67851216 | ||
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Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production | Q72020678 | ||
Accumulation of metformin by tissues of the normal and diabetic mouse | Q72381698 | ||
Inhibition of electron and energy transfer in mitochondria. II. The site and the mechanism of guanidine action | Q76463507 | ||
The relation of synthalin to carbohydrate metabolism | Q80326312 | ||
??? | Q64895651 | ||
P275 | copyright license | Creative Commons Attribution-NonCommercial 2.0 Generic | Q44128984 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 9 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | metformin | Q19484 |
amidines | Q423088 | ||
P304 | page(s) | 1898-1906 | |
P577 | publication date | 2013-07-09 | |
P1433 | published in | Diabetologia | Q5270140 |
P1476 | title | Molecular mechanism of action of metformin: old or new insights? | |
P478 | volume | 56 |
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Q51281697 | A novel polymorphism in protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) is associated with type 2 diabetes in the Han Chinese population. |
Q47240106 | A reappraisal on metformin |
Q94526301 | A review of cancer immunotherapy: from the past, to the present, to the future |
Q54365047 | A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators. |
Q35859585 | AMP-activated Protein Kinase Suppresses Biosynthesis of Glucosylceramide by Reducing Intracellular Sugar Nucleotides |
Q92601237 | AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells |
Q33824564 | AMPK activation: a therapeutic target for type 2 diabetes? |
Q57170002 | AMPK: Potential Therapeutic Target for Ischemic Stroke |
Q43809926 | Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial |
Q38734414 | Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells |
Q37692552 | Adipokines and insulin action: A sensitive issue |
Q90221587 | Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease |
Q90478040 | Advanced and multifaceted stability profiling of the first-line antidiabetic drugs metformin, gliclazide and glipizide under various controlled stress conditions |
Q40296763 | Aging metabolism: intervention strategies |
Q34003050 | An update on the pharmacogenomics of metformin: progress, problems and potential |
Q37187900 | Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status |
Q57281750 | Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial-mesenchymal transition in human colon cancer cells |
Q40251170 | Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes |
Q35675566 | Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. |
Q91597975 | Back to basics with active lifestyles: exercise is more effective than metformin to reduce cardiovascular risk in older adults with type 2 diabetes |
Q28541332 | Berberine promotes glucose consumption independently of AMP-activated protein kinase activation |
Q64941870 | Bidirectional regulation of adenosine 5'-monophosphate-activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration. |
Q65002446 | Capsaicin Analogues Derived from n-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro. |
Q42372108 | Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats |
Q34383575 | Cardiovascular impact of drugs used in the treatment of diabetes |
Q36520595 | Case-control study of oral glucose-lowering drugs in combination with long-acting insulin and the risks of incident myocardial infarction and incident stroke |
Q38147723 | Clinical relevance of target identity and biology: implications for drug discovery and development |
Q38945649 | Combatting type 2 diabetes by turning up the heat |
Q33605925 | Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis |
Q35800392 | Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. |
Q26740253 | Common medications used by patients with type 2 diabetes mellitus: what are their effects on the lipid profile? |
Q47817158 | Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial |
Q30373454 | Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration. |
Q26778957 | Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1 |
Q36427543 | Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass |
Q47144635 | Dual Therapy Appears Superior to Monotherapy for Low-Income Individuals With Newly Diagnosed Type 2 Diabetes. |
Q35535310 | Effect comparison of metformin with insulin treatment for gestational diabetes: a meta-analysis based on RCTs |
Q38948037 | Effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus and inadequate glycemic control |
Q48089757 | Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats. |
Q35944675 | Effects of caloric restriction and low glycemic index diets associated with metformin on glucose metabolism and cortisol response in overweight/obese subjects: a case series study. |
Q27003253 | Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain |
Q45718198 | Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial. |
Q37629041 | Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662. |
Q40989059 | Epithelial-Mesenchymal Transition Phenotype, Metformin, and Survival for Colorectal Cancer Patients with Diabetes Mellitus II. |
Q38607553 | Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes. |
Q48042047 | Functional interplay between LXR and AMPKα inhibits atherosclerosis in apoE deficient mice - A new anti-atherogenic strategy. |
Q53411897 | Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes. |
Q89462733 | Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice |
Q36253720 | Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. |
Q91991851 | Gut microbiome differences between metformin- and liraglutide-treated T2DM subjects |
Q35725065 | Gut microorganisms as promising targets for the management of type 2 diabetes |
Q44655644 | Head and neck cancers, the neglected malignancies: present and future treatment strategies |
Q57180762 | Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology |
Q36016417 | Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target |
Q34989872 | Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats |
Q35935123 | Interventions to Slow Aging in Humans: Are We Ready? |
Q28829020 | Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug |
Q35685308 | Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice |
Q47252413 | Lean Body Weight and Metformin Are Insufficient to Prevent Endometrial Hyperplasia in Mice Harboring Inactivating Mutations in PTEN. |
Q53706040 | Meta- and cross-species analyses of insulin resistance based on gene expression datasets in human white adipose tissues. |
Q39318607 | Metabolic Alterations at the Crossroad of Aging and Oncogenesis |
Q51533022 | Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer's Disease. |
Q37314264 | Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus |
Q91854786 | Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level |
Q58723952 | Metformin added to bosentan therapy in patients with pulmonary arterial hypertension associated with congenital heart defects: a pilot study |
Q35853068 | Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway |
Q35858703 | Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway |
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Q34151605 | Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis |
Q41038714 | Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state |
Q42256796 | Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity. |
Q53692797 | Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age. |
Q28539104 | Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells |
Q49180657 | Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells |
Q64105328 | Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts |
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Q47297378 | Metformin prevents ischaemic ventricular fibrillation in metabolically normal pigs |
Q55342484 | Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism. |
Q59882737 | Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase |
Q98386080 | Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells |
Q42362632 | Metformin selectively targets redox control of complex I energy transduction |
Q37364089 | Metformin treatment of antipsychotic-induced dyslipidemia: an analysis of two randomized, placebo-controlled trials |
Q36103093 | Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer |
Q35046673 | Metformin use and lung cancer risk in patients with diabetes. |
Q40930334 | Metformin use improves the survival of diabetic combined small-cell lung cancer patients |
Q92383575 | Metformin use is associated with a lower risk of uterine leiomyoma in female type 2 diabetes patients |
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