scholarly article | Q13442814 |
P356 | DOI | 10.1074/JBC.M212831200 |
P698 | PubMed publication ID | 12791703 |
P50 | author | Gwyn W Gould | Q38546624 |
Ian P Salt | Q56876361 | ||
Fabienne Foufelle | Q57058031 | ||
P2093 | author name string | John M C Connell | |
John R Petrie | |||
Valerie A Morrow | |||
P2860 | cites work | Regulation of endothelium-derived nitric oxide production by the protein kinase Akt | Q22010149 |
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation | Q22010150 | ||
P433 | issue | 34 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | endothelium | Q111140 |
P304 | page(s) | 31629-31639 | |
P577 | publication date | 2003-06-04 | |
P1433 | published in | Journal of Biological Chemistry | Q867727 |
P1476 | title | Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells | |
P478 | volume | 278 |
Q24815455 | 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory mediators in astroglia. |
Q41354131 | A new perspective on metformin therapy in type 1 diabetes |
Q60915789 | A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase |
Q37431885 | ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase |
Q55034947 | AMP-Activated Protein Kinase Mediates the Antiplatelet Effects of the Thiazolidinediones Rosiglitazone and Pioglitazone. |
Q22241925 | AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling |
Q39331294 | AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System. |
Q35641881 | AMP-activated protein kinase connects cellular energy metabolism to KATP channel function |
Q42269153 | AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production |
Q37286204 | AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury |
Q37734982 | AMP-activated protein kinase mediates the effects of lipoprotein-associated phospholipase A2 on endothelial dysfunction in atherosclerosis |
Q37411713 | AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease |
Q37332718 | AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells |
Q24610297 | AMP-activated protein kinase, stress responses and cardiovascular diseases |
Q52430975 | AMPK Phosphorylation of ACE2 in Endothelium Mitigates Pulmonary Hypertension. |
Q41989991 | AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney |
Q42580149 | AMPK activity is down-regulated in endothelial cells of GHS-R(-/-) mice. |
Q37386321 | AMPK and the biochemistry of exercise: implications for human health and disease |
Q37812782 | AMPK and vasculoprotection |
Q34807222 | AMPK in cardiovascular health and disease |
Q44987296 | AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo |
Q37153612 | AMPK: Lessons from transgenic and knockout animals |
Q26995682 | AMPK: a cellular metabolic and redox sensor. A minireview |
Q39849688 | Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway |
Q64018944 | Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice |
Q36257733 | Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells |
Q37259538 | Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure |
Q33796165 | Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase |
Q36174159 | Activation of AMP-activated protein kinase inhibits the proliferation of human endothelial cells |
Q34502017 | Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival |
Q40178851 | Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. |
Q46508470 | Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177. |
Q38450680 | Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries. |
Q28565968 | Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability |
Q24646027 | Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing |
Q35218922 | Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells |
Q38125624 | Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning |
Q37287612 | An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production |
Q38397635 | Antidiabetic agents and endothelial dysfunction - beyond glucose control |
Q37699841 | Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China. |
Q37270835 | Autophagy and metabolic changes in obesity-related chronic kidney disease |
Q38965186 | Berberine and Its Role in Chronic Disease |
Q37412690 | Berberine protects against palmitate-induced endothelial dysfunction: involvements of upregulation of AMPK and eNOS and downregulation of NOX4. |
Q46701739 | Beta-adrenoceptors, but not alpha-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1. |
Q37728337 | Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation |
Q50484704 | Bortezomib enhances fatty liver preservation in Institut George Lopez-1 solution through adenosine monophosphate activated protein kinase and Akt/mTOR pathways. |
Q47926400 | CB1 and CB2 Receptor Pharmacology |
Q42398897 | Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. |
Q36807567 | Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes. |
Q39379798 | Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention. |
Q42824929 | Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases |
Q47111436 | Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop |
Q37523452 | Chronic Exercise Training Improved Aortic Endothelial and Mitochondrial Function via an AMPKα2-Dependent Manner |
Q90448263 | Chronic dosing with metformin plus bosentan decreases in vitro pulmonary artery contraction from isolated arteries in adults with pulmonary hypertension |
Q49959084 | Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy |
Q24631754 | Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow |
Q36251554 | Defining the Molecular Nexus of Cancer, Type 2 Diabetes and Cardiovascular Disease |
Q46826234 | Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release |
Q90132277 | Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods |
Q35040806 | Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension |
Q37550688 | Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice |
Q28394686 | Effects of AMP-activated protein kinase in cerebral ischemia |
Q57256912 | Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins* |
Q54107598 | Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase (MELK) in Adrenocortical Carcinoma. |
Q58742216 | Endothelial AMP-Activated Kinase α1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation |
Q34518725 | Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling. |
Q38082465 | Endothelial dysfunction in (pre)diabetes: characteristics, causative mechanisms and pathogenic role in type 2 diabetes |
Q43576022 | Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. |
Q54639442 | Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent |
Q30406455 | Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside |
Q53633905 | Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARα Activation. |
Q41534752 | Estrogen Activates AMP-Activated Protein Kinase in Human Endothelial Cells via ERβ/Ca(2+)/Calmodulin-Dependent Protein Kinase Kinase β Pathway |
Q43188119 | Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation. |
Q38799483 | Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice |
Q38018381 | Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. |
Q57190536 | Fenofibrate improves vascular endothelial function and contractility in diabetic mice |
Q37396786 | Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression |
Q53106656 | Fucoidan from Undaria pinnatifida prevents vascular dysfunction through PI3K/Akt/eNOS-dependent mechanisms in the l-NAME-induced hypertensive rat model. |
Q28475897 | Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL |
Q51722308 | Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKα2. |
Q35169945 | Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism |
Q34384055 | Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMP-activated protein kinase-endothelial nitric-oxide synthase signaling pathway. |
Q55070081 | High-fat diet induces endothelial dysfunction through a down-regulation of the endothelial AMPK-PI3K-Akt-eNOS pathway. |
Q42321106 | Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation |
Q27021665 | Human obesity and endothelium-dependent responsiveness |
Q30485715 | ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration |
Q30438252 | Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle |
Q43238697 | Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis. |
Q37556027 | Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK-Akt-eNOS-NO Pathway in the Spontaneously Hypertensive Rat. |
Q34784602 | Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions |
Q37151167 | Loss of anti-contractile effect of perivascular adipose tissue in offspring of obese rats |
Q33717436 | Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells |
Q57822222 | Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease |
Q52673275 | Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase). |
Q38238017 | Mechanistic perspectives of calorie restriction on vascular homeostasis |
Q45065640 | Metabolic activation of AMP kinase in vascular smooth muscle |
Q58723952 | Metformin added to bosentan therapy in patients with pulmonary arterial hypertension associated with congenital heart defects: a pilot study |
Q54398245 | Metformin improves cardiac function in rats via activation of AMP-activated protein kinase. |
Q37582441 | Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms |
Q27320563 | Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation |
Q41661696 | Mild caloric restriction reduces blood pressure and activates endothelial AMPK-PI3K-Akt-eNOS pathway in obese Zucker rats. |
Q37518840 | Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes |
Q46398198 | Molecular cloning of ovine endothelial nitric oxide synthase and expression in COS-7 cells |
Q34022332 | Molecular insights and therapeutic targets for diabetic endothelial dysfunction |
Q22252798 | Molecular mechanism of action of metformin: old or new insights? |
Q93082445 | Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis |
Q40406496 | Myristic acid stimulates endothelial nitric-oxide synthase in a CD36- and an AMP kinase-dependent manner |
Q40226095 | Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle. |
Q34290008 | Novel therapeutic strategies for adult obese asthmatics |
Q42589408 | Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK. |
Q93204960 | Pharmacological effects of berberine on mood disorders |
Q28079712 | Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations |
Q35812975 | Plasticity of microvascular oxygenation control in rat fast-twitch muscle: effects of experimental creatine depletion |
Q35138347 | Potential benefits of berberine in the management of perimenopausal syndrome. |
Q54393648 | Prolonged AMP-activated protein kinase induction impairs vascular functions. |
Q37434434 | Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension. |
Q37488514 | Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. |
Q28537962 | Protein kinase D interacts with neuronal nitric oxide synthase and phosphorylates the activatory residue serine 1412 |
Q34044531 | Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation |
Q26849213 | Redox regulation of mitochondrial biogenesis |
Q40398353 | Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding. |
Q35925959 | Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems |
Q36830372 | Regulation of hepatic glucose uptake and storage in vivo |
Q35886665 | Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium |
Q37445518 | Resveratrol: a promising agent in promoting cardioprotection against coronary heart disease |
Q54110987 | Reversing age-associated arterial dysfunction: insight from preclinical models. |
Q47920712 | Rhodiola crenulata Attenuates High Glucose Induced Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells |
Q82336875 | Role of AMP-activated protein kinase in α-lipoic acid-induced vasodilatation in spontaneously hypertensive rats |
Q33840570 | Role of the energy sensor AMP-activated protein kinase in renal physiology and disease |
Q47273073 | SNF1-related protein kinases type 2 are involved in plant responses to cadmium stress |
Q40723319 | Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway |
Q92641731 | Shear stress regulation of miR-93 and miR-484 maturation through nucleolin |
Q34649302 | Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCa channels and adiponectin. |
Q89884450 | Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ |
Q54533625 | Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction. |
Q42759674 | Supplementation of creatine and ribose prevents apoptosis in ischemic cardiomyocytes. |
Q90478656 | The Vascular Consequences of Metabolic Syndrome: Rodent Models, Endothelial Dysfunction, and Current Therapies |
Q42137439 | The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice |
Q35614956 | The role of metformin in the management of NAFLD |
Q34091638 | The use of metformin in type 1 diabetes: a systematic review of efficacy |
Q24670614 | Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta |
Q45029420 | Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt |
Q49953580 | Toll-like receptor 9-dependent AMPKα activation occurs via TAK1 and contributes to RhoA/ROCK signaling and actin polymerization in vascular smooth muscle cells |
Q37977719 | Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes |
Q42174557 | Ubiquitin-proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms |
Q40328533 | Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endotheli |
Q39494703 | Urban particulate matter activates Akt in human lung cells |
Q90308406 | VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1 |
Q38419222 | Vascular AMPK as an attractive target in the treatment of vascular complications of obesity. |
Q38657890 | cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. |
Q35092798 | eNOS-dependent antisenscence effect of a calcium channel blocker in human endothelial cells |
Q37415163 | α1AMP-activated protein kinase mediates vascular protective effects of exercise. |
Q42482105 | α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation |