AMPK and vasculoprotection

scientific article published on November 25, 2010

AMPK and vasculoprotection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.PHARMTHERA.2010.11.002
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0163725810002172?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0163725810002172?httpAccept=text/xml
P698PubMed publication ID21111758
P5875ResearchGate publication ID49639637

P50authorSimon KennedyQ88194959
P2093author name stringMarie-Ann Ewart
P2860cites workComplexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeQ21245891
Role of AMP-activated protein kinase in mechanism of metformin actionQ22241898
AMP-Activated Protein Kinase in Metabolic Control and Insulin SignalingQ22241925
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP bindingQ22253261
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmQ24296287
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADQ24305094
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscleQ24313307
The AMP-activated protein kinase--fuel gauge of the mammalian cell?Q24315074
Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseQ24561682
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutationsQ24614590
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory siteQ24645338
Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetesQ24656627
Atherosclerosis — An Inflammatory DiseaseQ26776972
The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complexQ27939219
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscleQ28199222
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseQ28215845
AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal locationQ28243750
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transductionQ28271470
In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurinQ28281084
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinaseQ28291824
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinaseQ28296225
Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localizationQ28348247
Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytesQ28507295
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinaseQ42165233
Nitric oxide mediates the effect of fluvastatin on intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression on human endothelial cellsQ42476708
Phenotypic and functional changes in regenerated porcine coronary endothelial cells : increased uptake of modified LDL and reduced production of NO.Q42487303
The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase.Q42504598
Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents.Q42509038
Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db miceQ42515022
Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase.Q42523433
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633Q42582636
Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissuesQ42805365
Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunctionQ43097840
Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusionQ43132682
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.Q43186674
Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuliQ43248509
A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.Q43298108
Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in miceQ44079684
Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cellsQ44273159
Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK ratsQ44303781
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cellsQ44468960
Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL.Q44540704
AICAR stimulates adiponectin and inhibits cytokines in adipose tissueQ44807015
Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen speciesQ44987425
Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamusQ44995520
Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-AktQ45029420
Metabolic activation of AMP kinase in vascular smooth muscleQ45065640
Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.Q46116517
AMP-activated kinase may suppress NADPH oxidase activation in vascular tissuesQ46139590
Statins activate AMP-activated protein kinase in vitro and in vivoQ46230916
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.Q46236023
Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinaseQ46359191
Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinaseQ46368505
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinaseQ28567006
The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitroQ28582647
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminQ28590162
LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxideQ29547245
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chainQ29615210
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismQ29617261
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?Q29618095
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?Q29618125
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarctionQ29618673
Structure and function of AMP-activated protein kinase.Q30375195
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.Q32043995
Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitroQ33249851
Development of novel adenosine monophosphate-activated protein kinase activatorsQ33532741
Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end productsQ33595290
Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivoQ33675689
Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cellsQ33717436
Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthaseQ33796165
The protease inhibitor UCF-101 ameliorates streptozotocin-induced mouse cardiomyocyte contractile dysfunction in vitro: role of AMP-activated protein kinaseQ33827744
Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivinQ33832521
AMP-activated protein kinase activation as a strategy for protecting vascular endothelial functionQ33848040
Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivoQ33869754
AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylationQ33874358
Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic responseQ33912715
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinaseQ33953064
Peroxynitrite Increases Protein Phosphatase Activity and Promotes the Interaction of Phospholamban with Protein Phosphatase 2a in the Myocardium.Q34018767
AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomesQ34059872
Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathwayQ34132341
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.Q34196949
AMPK beta subunit targets metabolic stress sensing to glycogenQ34196956
Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient miceQ34236808
The structure of a domain common to archaebacteria and the homocystinuria disease proteinQ34415436
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.Q34438345
Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPKQ34440321
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscleQ34452979
Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetesQ46396936
A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II).Q46528602
Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cellsQ46665864
Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetesQ46680292
Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.Q46731659
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin actionQ46745033
Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK.Q46810678
Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats.Q46828442
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.Q46844438
Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.Q46890287
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism.Q46966126
High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cellsQ47235182
AMPKalpha1 regulates the antioxidant status of vascular endothelial cellsQ47801068
AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stressQ47858200
Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivoQ48360342
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.Q50337113
Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinaseQ50337120
Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5'-monophosphate.Q53761638
Thiazolidinediones: an update.Q54055332
The regulation of AMP-activated protein kinase by phosphorylationQ55933913
The Effect of AMP-Activated Protein Kinase and Its Activator AICAR on the Metabolism of Human Umbilical Vein Endothelial CellsQ58108374
Fluid Shear Stress and NO Decrease the Activity of the Hydroxy-Methylglutaryl Coenzyme A Reductase in Endothelial Cells via the AMP-Activated Protein Kinase and FoxO1Q60760123
The Nitric Oxide-Donating Pravastatin Derivative, NCX 6550 [(1S-[1 (betaS*, S*), 2 , 6 , 8beta-(R*), 8a ]]-1,2,6,7,8,8a-Hexahydro-beta, , 6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic Acid 4-(Nitrooxy)butyl Ester)], Reduces SpQ60998569
Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in miceQ64018944
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesisQ69907652
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanismsQ71824256
High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylaseQ71892100
AMP-activated protein kinase phosphorylation of endothelial NO synthaseQ74456171
Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinaseQ77410226
5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactionsQ80174822
Nitric oxide generation by NO donors is enhanced following balloon injury in the porcine coronary arteryQ80320311
The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cellsQ81646507
Acadesine, an adenosine-regulating agent with the potential for widespread indicationsQ94705349
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.Q34522920
Diabetes and atherosclerosis: epidemiology, pathophysiology, and managementQ34646074
C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrestQ34852643
Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid productionQ35070737
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cellsQ35218922
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathwayQ35768634
Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cellsQ35773071
NADPH oxidase and endothelial cell functionQ36232155
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.Q36301403
AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancerQ36448932
AMP-activated protein kinase: Role in metabolism and therapeutic implicationsQ36616554
AMP-activated protein kinase in the heart: role during health and diseaseQ36749088
Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivoQ36761895
Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism.Q36807630
Modulation of PPAR activity via phosphorylationQ36846134
Pro-healing drug-eluting stents: a role for antioxidants?Q37056666
In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase IQ37267054
AMP-activated protein kinase promotes the differentiation of endothelial progenitor cellsQ37332718
Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxinQ37360483
Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.Q37365504
Cardiovascular effects of disturbed insulin activity in metabolic syndrome and in type 2 diabetic patientsQ37392192
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic diseaseQ37411713
Activation and signaling by the AMP-activated protein kinase in endothelial cellsQ37553770
The role of AMP-activated protein kinase in the cardiovascular systemQ37632263
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.Q38298758
A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunitsQ38308990
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndromeQ38312576
AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathwayQ39682741
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activationQ39697365
Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channelQ39734364
AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPaseQ39787435
Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS PathwayQ39788216
Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanismQ39815253
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase.Q39878461
Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase.Q40178851
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.Q40223208
Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.Q40416595
Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cellsQ41901421
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)242-253
P577publication date2010-11-25
P1433published inPharmacology & TherapeuticsQ3378596
P1476titleAMPK and vasculoprotection
P478volume131

Reverse relations

cites work (P2860)
Q37954821AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease.
Q47912246AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway
Q37175528AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury
Q37881988AMP-activated protein kinase: a potential player in Alzheimer's disease
Q89842749AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy
Q52430975AMPK Phosphorylation of ACE2 in Endothelium Mitigates Pulmonary Hypertension.
Q38998402AMPK/Mitochondria in Metabolic Diseases
Q46142341Acetylcholine-induced AMP-activated protein kinase activation attenuates vasoconstriction through an LKB1-dependent mechanism in rat aorta
Q51724997Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation.
Q35128571Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages
Q92649647Adenosine Monophosphate-Activated Protein Kinase Signaling Regulates Lipid Metabolism in Response to Salinity Stress in the Red-Eared Slider Turtle Trachemys scripta elegans
Q36288862Alterations of specific biomarkers of metabolic pathways in vascular tree from patients with Type 2 diabetes
Q54229729Ampelopsin protects endothelial cells from hyperglycemia-induced oxidative damage by inducing autophagy via the AMPK signaling pathway.
Q34444895Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease
Q39179519Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen
Q39379798Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.
Q90448263Chronic dosing with metformin plus bosentan decreases in vitro pulmonary artery contraction from isolated arteries in adults with pulmonary hypertension
Q38733796Clinical Trials in Pediatric Autosomal Dominant Polycystic Kidney Disease
Q37522889Constitutive activation of AMPK α1 in vascular endothelium promotes high-fat diet-induced fatty liver injury: role of COX-2 induction
Q95852043Contribution of Rho-kinase and Adenosine Monophosphate-Activated Protein Kinase Signaling Pathways to Endothelium-Derived Contracting Factors Responses
Q38692469Coordinating Regulation of Gene Expression in Cardiovascular Disease: Interactions between Chromatin Modifiers and Transcription Factors
Q46826234Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release
Q33682914Dissecting the role of AMP-activated protein kinase in human diseases
Q89880144GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease-A Systematic Review
Q38770370Globular CTRP9 inhibits oxLDL-induced inflammatory response in RAW 264.7 macrophages via AMPK activation
Q37364108Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1.
Q40536569Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response
Q34474278Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis
Q37440481Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury
Q41661696Mild caloric restriction reduces blood pressure and activates endothelial AMPK-PI3K-Akt-eNOS pathway in obese Zucker rats.
Q42198231Nitric oxide synthesis-promoting effects of valsartan in human umbilical vein endothelial cells via the Akt/adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway
Q42279758Normal IgG downregulates the intracellular superoxide level and attenuates migration and permeability in human aortic endothelial cells isolated from a hypertensive patient
Q57283056Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword
Q37671282Perivascular fat, AMP-activated protein kinase and vascular diseases.
Q35925959Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
Q53065024Regulatory effect of AMP-activated protein kinase on pulmonary hypertension induced by chronic hypoxia in rats: in vivo and in vitro studies.
Q92814951Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway
Q36595077Salidroside exerts protective effects against chronic hypoxia-induced pulmonary arterial hypertension via AMPKα1-dependent pathways
Q90084151TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation
Q44405235The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation
Q38594411The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to a possible new molecular target in the management of chronic inflammatory disorders
Q42137439The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice
Q49953580Toll-like receptor 9-dependent AMPKα activation occurs via TAK1 and contributes to RhoA/ROCK signaling and actin polymerization in vascular smooth muscle cells
Q38419222Vascular AMPK as an attractive target in the treatment of vascular complications of obesity.
Q48211515Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats.

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