AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633

scientific article published on 8 January 2009

AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.108.187567
P8608Fatcat IDrelease_ycnii2ruk5dhjlv3igexc3qlb4
P932PMC publication ID2761102
P698PubMed publication ID19131647
P5875ResearchGate publication ID23766421

P50authorMing-Daw TsaiQ40453365
P2093author name stringWei Sun
Zhen Chen
Yi Zhu
Mei-I Su
Pang-Hung Hsu
John Y-J Shyy
Yi Fu
Songqin Pan
I-Chen Peng
Kathryn DeFea
P2860cites workEndothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increaseQ40622130
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assayQ41758439
Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activitiesQ41764509
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthaseQ42437220
Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinaseQ43568413
Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A.Q43812771
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanismQ44182985
Adiponectin stimulates production of nitric oxide in vascular endothelial cells.Q44565932
Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitorsQ44846597
Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscleQ44987298
AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress.Q46037787
Statins activate AMP-activated protein kinase in vitro and in vivoQ46230916
Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.Q46557763
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signalingQ46847423
AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267.Q46851056
Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.Q53551231
Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871.Q54638032
Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.Q55043111
Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.Q55065507
Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylationQ57219989
Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinasesQ73441813
AMP-activated protein kinase phosphorylation of endothelial NO synthaseQ74456171
Regulation of endothelium-derived nitric oxide production by the protein kinase AktQ22010149
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylationQ22010150
AMP-Activated Protein Kinase in Metabolic Control and Insulin SignalingQ22241925
Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunitQ24294651
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivityQ24554361
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorQ28299224
Specificity and mechanism of action of some commonly used protein kinase inhibitorsQ28344791
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineQ29547539
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?Q29618095
Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635.Q33184040
Mammalian nitric oxide synthasesQ33631306
Enzymatic function of nitric oxide synthasesQ33847576
Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.Q33950554
Nitric oxide insufficiency, platelet activation, and arterial thrombosisQ34234301
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironmentsQ35070875
eNOS at a glanceQ35782010
Endothelial function: cardiac eventsQ36019119
Endothelial-cardiomyocyte interactions in cardiac development and repairQ36387870
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylationQ36535244
AMP-activated protein kinase as a drug target.Q36551887
AMP-activated protein kinase in the heart: role during health and diseaseQ36749088
Disabling a C-terminal autoinhibitory control element in endothelial nitric-oxide synthase by phosphorylation provides a molecular explanation for activation of vascular NO synthesis by diverse physiological stimuli.Q38292157
P433issue4
P921main subjectendotheliumQ111140
phosphorylationQ242736
P304page(s)496-505
P577publication date2009-01-08
P1433published inCirculation ResearchQ2599020
P1476titleAMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
P478volume104

Reverse relations

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