Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

scientific article published on 13 October 2016

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2337/DB16-0915
P932PMC publication ID5204316
P698PubMed publication ID27737949

P2093author name stringMiao Zhang
Qilong Wang
Shengnan Wu
Zhonglin Xie
Ming-Hui Zou
Gloria Torres
Changhan Ouyang
P2860cites workC-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetesQ37251110
In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase IQ37267054
Endothelial cell-specific liver kinase B1 deletion causes endothelial dysfunction and hypertension in mice in vivoQ37678614
Mitochondrial dynamics in peripheral neuropathiesQ38175425
Hypertension and insulin resistance: implications of mitochondrial dysfunctionQ38272560
Redox Homeostasis and Mitochondrial Dynamics.Q38545789
AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1.Q39104609
Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosisQ39937641
Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis.Q40791385
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633Q42582636
Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic miceQ42809915
Primary preventive effect of metformin upon atherosclerosis in patients with type 2 diabetes mellitusQ43199472
Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetesQ44882775
Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.Q46557763
Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cellsQ46870176
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction.Q50952957
Inhibition to DRP1 translocation can mitigate p38 MAPK-signaling pathway activation in GMC induced by hyperglycemia.Q52952699
The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.Q53194946
Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis.Q53648299
NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated AtherosclerosisQ56991358
Dietary supplementation with fish oil alters the expression levels of proteins governing mitochondrial dynamics and prevents high-fat diet-induced endothelial dysfunctionQ87771640
Dysregulation of HSG triggers vascular proliferative disordersQ24301690
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stressQ27330478
Biochemistry and molecular cell biology of diabetic complicationsQ28131781
Mitochondrial fusion and fission in cell life and deathQ28299119
Redox regulation of endothelial cell fateQ28392484
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagyQ29615616
Report of the Expert Committee on the Diagnosis and Classification of Diabetes MellitusQ29616284
Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivoQ33675689
Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo.Q33922718
AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomesQ34059872
Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosisQ34447321
Oxidative stress as a mechanism of added sugar-induced cardiovascular diseaseQ34452521
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphologyQ34479807
TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesisQ34601950
Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytesQ34665300
Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 miceQ35043474
Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injuryQ35056744
Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosisQ35114963
Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitusQ35144163
Mitofusins are required for angiogenic function and modulate different signaling pathways in cultured endothelial cells.Q35529133
Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes modelQ35532253
Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney diseaseQ35658612
Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscleQ35665651
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cellsQ35754670
Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesionsQ35781399
Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathyQ36225147
Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation.Q36642535
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery diseaseQ36782688
Endothelial mitochondria: contributing to vascular function and diseaseQ36803365
Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities.Q37245109
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
mitochondrial fissionQ6881852
atherosclerosisQ12252367
P304page(s)193-205
P577publication date2016-10-13
P1433published inDiabetesQ895262
P1476titleMetformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
P478volume66

Reverse relations

cites work (P2860)
Q52341567AMP-activated protein kinase protects against necroptosis via regulation of Keap1-PGAM5 complex.
Q46399403AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation
Q92594570Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs
Q62492538Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery
Q59134796Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics
Q55381729Defective Autophagy in Atherosclerosis: To Die or to Senesce?
Q92209786Diallyl trisulfide attenuates hyperglycemia-induced endothelial apoptosis by inhibition of Drp1-mediated mitochondrial fission
Q47436464Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.
Q33588277Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1.
Q91722311Drp1 and RB interaction to mediate mitochondria-dependent necroptosis induced by cadmium in hepatocytes
Q38728964Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Q92477726Effects of Timolol Treatment on Pancreatic Antioxidant Enzymes in Streptozotocin-induced Diabetic Rats: An Experimental and Computational Study
Q91813906Eliciting α7-nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling
Q47201817Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission.
Q48278599Excessive Endoplasmic Reticulum Stress Correlates with Impaired Mitochondrial Dynamics, Mitophagy and Apoptosis, in Liver and Adipose Tissue, but Not in Muscles in EMS Horses
Q92618502FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics
Q48042047Functional interplay between LXR and AMPKα inhibits atherosclerosis in apoE deficient mice - A new anti-atherogenic strategy.
Q60922054HSP22 suppresses diabetes-induced endothelial injury by inhibiting mitochondrial reactive oxygen species formation
Q97643920Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity
Q64982218High glucose induces apoptosis of HUVECs in a mitochondria-dependent manner by suppressing hexokinase 2 expression.
Q48042214How AMPK and PKA Interplay to Regulate Mitochondrial Function and Survival in Models of Ischemia and Diabetes
Q89906870Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway
Q91575299Ilexgenin A inhibits mitochondrial fission and promote Drp1 degradation by Nrf2-induced PSMB5 in endothelial cells
Q64916442Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Q101149141Low-glucose-sensitive TRPC6 dysfunction drives hypoglycemia-induced cognitive impairment in diabetes
Q52685560Measurement of Reactive Oxygen Species (ROS) and Mitochondrial ROS in AMPK Knockout Mice Blood Vessels.
Q90301380Mechanisms of action of metformin with special reference to cardiovascular protection
Q88162418Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway
Q41066189Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis
Q58799669Mesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy
Q93011588Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice
Q59128194Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway
Q64375136Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway
Q99629109Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells
Q92688756Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
Q91580806Metformin improved oxidized low-density lipoprotein-impaired mitochondrial function and increased glucose uptake involving Akt-AS160 pathway in raw264.7 macrophages
Q91071470Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the Sirt1/NF-κB signaling pathway in vascular smooth muscle cells
Q90622824Metformin inhibits high glucose-induced smooth muscle cell proliferation and migration
Q49406991Metformin protects against oxidized low density lipoprotein-induced macrophage apoptosis and inhibits lipid uptake.
Q98386080Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells
Q47246258Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16.
Q97643486Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss
Q59138339Metformin: An Old Drug with New Applications
Q64087849Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model
Q55007433Mitochondrial Dynamics in Type 2 Diabetes and Cancer.
Q90556166Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing
Q91982108Mitochondrial Dysfunction and Diabetes: Is Mitochondrial Transfer a Friend or Foe?
Q39107426Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications.
Q92839769Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials
Q64889515Mulberry Extract Attenuates Endothelial Dysfunction through the Regulation of Uncoupling Endothelial Nitric Oxide Synthase in High Fat Diet Rats.
Q58121145New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis
Q59353447Operation of mitochondrial machinery in viral infection-induced immune responses
Q41509991Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production.
Q88487528Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Q64071134Role of autophagy in atherosclerosis: foe or friend?
Q64101867S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1
Q47292284Snf1 (Sucrose Nonfermenting 1)-Related Kinase Promotes Angiogenesis In Vivo
Q98289614The Role of Oxidative Stress in Physiopathology and Pharmacological Treatment with Pro- and Antioxidant Properties in Chronic Diseases
Q90389861Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
Q93168764Vildagliptin improves high glucose-induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission
Q92092606[Metformin inhibits aortic atherosclerosis in mice by regulating actin skeleton in vascular smooth muscle cells]

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