Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model

scientific article published on 20 November 2014

Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2337/DB14-0758
P932PMC publication ID4407851
P698PubMed publication ID25412623

P2093author name stringGuy M McKhann
Long Wu
Haiyang Yu
Shirley ShiDu Yan
Gang Hu
Alexander A Sosunov
Shengbin Huang
Yongfu Wang
Du Fang
Xueqi Gan
Changjia Zhong
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Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.Q53548157
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.Q53571110
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Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell deathQ29620448
RALA and RALBP1 regulate mitochondrial fission at mitosisQ30503960
Diabetes regulates mitochondrial biogenesis and fission in mouse neurons.Q33571558
Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic ratsQ33853599
Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cellsQ33890981
Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetesQ33940901
Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetesQ33996111
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neuronsQ34083053
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db miceQ34376178
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphologyQ34479807
GSK3beta-mediated Drp1 phosphorylation induced elongated mitochondrial morphology against oxidative stressQ34489873
Mitochondrial dynamics in diabetesQ34511749
Mitochondrial fusion and fission in mammalsQ34526830
Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitusQ35144163
Mitochondrial Ca(2+) uptake is essential for synaptic plasticity in painQ35229769
Advanced glycation end product level, diabetes, and accelerated cognitive agingQ35240099
Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscleQ35665651
Neurocognitive correlates of type 1 diabetes mellitus in childhoodQ35672632
Synergistic exacerbation of mitochondrial and synaptic dysfunction and resultant learning and memory deficit in a mouse model of diabetic Alzheimer's diseaseQ35738734
D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson diseaseQ35919815
IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiationQ36073656
Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytesQ36215833
Impact of impaired glucose tolerance and type 2 diabetes on cognitive agingQ36291141
High-fat diets, insulin resistance and declining cognitive functionQ36300635
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationQ36496658
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphologyQ36817918
Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen speciesQ37107583
Synaptic ultrastructural alterations anticipate the development of neuroaxonal dystrophy in sympathetic ganglia of aged and diabetic miceQ37149806
Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodelingQ37193667
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Mitochondrial networking protects beta-cells from nutrient-induced apoptosis.Q37360471
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P1104number of pages15
P304page(s)1728-1742
P577publication date2014-11-20
P1433published inDiabetesQ895262
P1476titleDrp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model
P478volume64

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