AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

scientific article published on April 2009

AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1042/CS20080066
P932PMC publication ID2762688
P698PubMed publication ID19275766

P2093author name stringChim C Lang
Jacqueline Howie
John R Petrie
Aaron K F Wong
P2860cites workPrevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S.Q44470244
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heartQ44532391
AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cellsQ44538214
Adiponectin stimulates production of nitric oxide in vascular endothelial cells.Q44565932
AICAR stimulates adiponectin and inhibits cytokines in adipose tissueQ44807015
Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?Q44816749
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyteQ44907827
AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferationQ44985604
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeQ21245891
Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 DiabetesQ22241283
Role of AMP-activated protein kinase in mechanism of metformin actionQ22241898
Metabolic actions of metformin in the heart can occur by AMPK-independent mechanismsQ22241963
Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentrationQ22241965
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular CausesQ22250883
MetforminQ22250907
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemiaQ24290495
Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesisQ24291256
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathyQ24292259
Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrateQ24296690
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Q24310603
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutationsQ24614590
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alphaQ24793384
Nitric oxide: physiology, pathophysiology, and pharmacologyQ26778243
Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase SignalingQ27832095
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
Identification of a gene responsible for familial Wolff-Parkinson-White syndromeQ28201949
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseQ28215845
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signalingQ28216932
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesisQ28218978
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in strokeQ28240112
AMP-activated protein kinase plays a role in the control of food intakeQ28240521
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamusQ28254114
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylationQ28271672
Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylaseQ28283715
Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinaseQ28574062
Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heartQ28574917
LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) GroupQ29547282
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chainQ29615210
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)Q29615693
Leptin and the regulation of body weight in mammalsQ29615976
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trialQ29619886
Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trialQ29622926
Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome: natural historyQ33152428
Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.Q33184967
Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndromeQ33229028
The role of TNFalpha and TNF receptors in obesity and insulin resistanceQ33680471
Adiponectin-mediated modulation of hypertrophic signals in the heartQ33688678
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanismsQ33688706
Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism.Q41693724
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO productionQ42269153
Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivoQ42455836
Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR.Q42476103
Nitric oxide mediates the effect of fluvastatin on intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression on human endothelial cellsQ42476708
Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.Q43596018
Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophyQ43753479
Energy substrate utilization by isolated working hearts from newborn rabbitsQ44000073
Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in miceQ44007043
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndromeQ44043225
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytesQ44086594
AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed ratsQ44155454
Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinaseQ44453273
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cellsQ44468960
Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery diseaseQ45213515
Dual mechanisms regulating AMPK kinase action in the ischemic heart.Q45226539
Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational studyQ45256257
Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanismQ45281571
Statins activate AMP-activated protein kinase in vitro and in vivoQ46230916
AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndromeQ46432574
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolismQ46502051
Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administrationQ46591896
Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanismsQ46601702
Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetesQ46680292
Improved clinical outcomes associated with metformin in patients with diabetes and heart failureQ46722279
Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.Q46731659
Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscleQ46764341
Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxideQ46789134
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signalingQ46847423
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.Q46952844
Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism.Q46966126
Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosisQ46973117
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.Q47866453
Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in ratsQ48207714
Plasma fatty acid levels in infants and adults after myocardial ischemia.Q51630314
Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.Q52541795
Effects of acadesine on myocardial infarction, stroke, and death following surgery. A meta-analysis of the 5 international randomized trials. The Multicenter Study of Perioperative Ischemia (McSPI) Research Group.Q53361960
Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosolQ68671948
Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylationQ69493948
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesisQ69907652
Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivoQ73012623
Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic miceQ73048909
AMP-activated protein kinase phosphorylation of endothelial NO synthaseQ74456171
Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophyQ77363631
Effect of AMPK activation on muscle glucose metabolism in conscious ratsQ77755573
A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetesQ79792326
Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery diseaseQ80519509
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.Q33821960
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.Q33929661
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistanceQ33941406
Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.Q34012881
Lipotoxic diseasesQ34111950
AMPK beta subunit targets metabolic stress sensing to glycogenQ34196956
The structure of a domain common to archaebacteria and the homocystinuria disease proteinQ34415436
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activationQ34416242
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscleQ34452979
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.Q34506457
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.Q34522920
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanismQ34525699
5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.Q34629958
Rosiglitazone evaluated for cardiovascular outcomes--an interim analysisQ34634794
AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppressionQ34764173
Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetesQ35053050
Neuroprotection mediated by changes in the endothelial actin cytoskeleton.Q35128290
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.Q35213694
Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).Q35566946
Prevalence of the metabolic syndrome in US populationsQ35781474
Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidenceQ36177005
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.Q36248613
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disordersQ36462591
AMPK alterations in cardiac physiology and pathology: enemy or ally?Q36475855
Effect of pioglitazone on cardiovascular outcome in diabetes and chronic kidney diseaseQ36667186
Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sampleQ36834958
Preprocedural statin therapy in percutaneous coronary interventionQ36915760
Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trialsQ36955489
Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1Q37111703
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injuryQ37286204
5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) miceQ38292086
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndromeQ38312576
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growthQ40105523
Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activationQ40403270
Interleukin-6 induces cellular insulin resistance in hepatocytesQ40687381
Free fatty acid metabolism during myocardial ischemia and reperfusionQ41358557
P275copyright licenseCreative Commons Attribution-NonCommercial 2.5 GenericQ19113746
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectpeptideQ172847
enzymeQ8047
cardiovascular diseaseQ389735
metabolic syndromeQ657193
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)607-620
P577publication date2009-04-01
P1433published inClinical ScienceQ372419
P1476titleAMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease
P478volume116

Reverse relations

cites work (P2860)
Q382226055-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects
Q409342795-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside-attenuates LPS/D-Gal-induced acute hepatitis in mice
Q36815297A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats
Q39801353A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection.
Q33932744A single nucleotide polymorphism in STK11 influences insulin sensitivity and metformin efficacy in hyperinsulinemic girls with androgen excess.
Q41684518AICAR Administration Attenuates Hemorrhagic Hyperglycemia and Lowers Oxygen Debt in Anesthetized Male Rabbits
Q37108786AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: Suppression of HSP27 phosphorylation via p44/p42 MAP kinase.
Q37856788AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
Q37671250AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease.
Q37951443AMPK - Activated Protein Kinase and its Role in Energy Metabolism of the Heart
Q42879466AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE-/- mice
Q53372149AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.
Q41989991AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney
Q47369070AMPK and cardiac remodelling.
Q37812782AMPK and vasculoprotection
Q35920708AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol.
Q92623635AMPK: a balancer of the renin-angiotensin system
Q60921233AMPK: a therapeutic target of heart failure-not only metabolism regulation
Q45013474Activation of Adenosine Monophosphate-Activated Protein Kinase Is an Additional Mechanism That Participates in Mediating Inhibitory Actions of Prostaglandin F2Alpha in Mature, but Not Developing, Bovine Corpora Lutea
Q38450680Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries.
Q44418878An Update on AMPK in Hydrogen Sulfide Pharmacology
Q34189477Anti-inflammatory nutrition as a pharmacological approach to treat obesity
Q51750481Beneficial effect of the bioflavonoid quercetin on cholecystokinin-induced mitochondrial dysfunction in isolated rat pancreatic acinar cells.
Q37052961CHIP protects against cardiac pressure overload through regulation of AMPK.
Q36051510Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis
Q56535621Cathepsins: Proteases that are vital for survival but can also be fatal
Q28081013Cellular and molecular biology of aging endothelial cells
Q91851182Clinical evidence-guided network pharmacology analysis reveals a critical contribution of β1-adrenoreceptor upregulation to bradycardia alleviation by Shenxian-Shengmai
Q36251554Defining the Molecular Nexus of Cancer, Type 2 Diabetes and Cardiovascular Disease
Q49247394Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease
Q64949572Drug repurposing in alternative medicine: herbal digestive Sochehwan exerts multifaceted effects against metabolic syndrome.
Q54616760Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.
Q35838049Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection?
Q43091072Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure.
Q34855692Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer
Q54440549HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome.
Q83749924Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase
Q36185141Insulin down-regulates the expression of ubiquitin E3 ligases partially by inhibiting the activity and expression of AMP-activated protein kinase in L6 myotubes
Q36821424Insulin resistance: metabolic mechanisms and consequences in the heart.
Q37636514Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry
Q57822222Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease
Q36820974Metabolic switching and fuel choice during T-cell differentiation and memory development
Q55032055Metformin alleviates vascular calcification induced by vitamin D3 plus nicotine in rats via the AMPK pathway.
Q35114963Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis
Q51373277Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure.
Q35796984Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity.
Q33793434Metformin therapy and outcomes in patients with advanced systolic heart failure and diabetes
Q21134128Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25
Q38829598New synthetic AICAR derivatives with enhanced AMPK and ACC activation
Q37927098Nitric oxide: orchestrator of endothelium-dependent responses
Q37786170Novel regulators and drug targets of cardiac hypertrophy
Q36227345Oestrogen receptors interact with the α-catalytic subunit of AMP-activated protein kinase
Q58579343Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public
Q37801370Pharmacological treatment of obesity in children and adolescents: current status and perspectives.
Q37817710Physical activity as the main therapeutic tool for metabolic syndrome in childhood
Q35613008Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury
Q30234943Progress of small molecular inhibitors in the development of anti-influenza virus agents
Q34214717Protection from Doxorubicin-Induced Cardiomyopathy Using the Modified Anthracycline N-Benzyladriamycin-14-valerate (AD 198)
Q38377369Quantitative cardiac phosphoproteomics profiling during ischemia-reperfusion in an immature swine model
Q34756301Regulation of AMPK by the ubiquitin proteasome system
Q34998025Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways
Q38298547Screening methods for AMP-activated protein kinase modulators: a patent review
Q47711349Snail/beta-catenin signaling protects breast cancer cells from hypoxia attack
Q36329814Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin
Q59133335Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose
Q27694733Targeting myocardial substrate metabolism in heart failure: potential for new therapies
Q37400658The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling
Q53101458The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats.
Q89604720The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
Q36031170The influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the Taiwanese
Q28080686The role of Fatty Acid oxidation in the metabolic reprograming of activated t-cells
Q26748610The signaling involving in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases
Q28534586Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death
Q34969926Three 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC.
Q33884299To eat or not to eat: the effect of AICAR on food intake regulation in yellow-bellied marmots (Marmota flaviventris)
Q53242482Transient energy deficit induced by exercise increases 24-h fat oxidation in young trained men.
Q58447602Type 2 diabetes mellitus

Search more.