A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase

scientific article published on 05 December 2018

A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase is …
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scholarly articleQ13442814

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P356DOI10.3390/IJMS19123886
P932PMC publication ID6321332
P698PubMed publication ID30563079

P50authorIan P SaltQ56876361
Timothy M PalmerQ60975831
George BaillieQ73827461
P2093author name stringSarah J Mancini
Anastasiya Strembitska
Jonathan M Gamwell
P2860cites workPhosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.Q51284981
AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.Q52309562
Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles.Q53668959
Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms.Q54119005
Vascular nitric oxide: Beyond eNOSQ26779400
Structural basis of AMPK regulation by small molecule activatorsQ27680957
The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitroQ28582647
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant miceQ28591122
The Akt kinase signals directly to endothelial nitric oxide synthaseQ28609847
Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activitiesQ29347074
VEGF receptor signalling - in control of vascular functionQ29617256
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Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosideQ30406455
Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthaseQ33796165
Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implicationsQ33901576
Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survivalQ34502017
Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling.Q34518725
Elevated NF-κB activation is conserved in human myocytes cultured from obese type 2 diabetic patients and attenuated by AMP-activated protein kinaseQ35405108
Insulin, IGF-1 and longevityQ35806709
Activation of AMP-activated protein kinase inhibits the proliferation of human endothelial cellsQ36174159
The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic DevelopmentQ36258703
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.Q36301403
Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterationsQ36906571
Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award LectureQ36930826
Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cellsQ37358571
Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487.Q37488514
Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylationQ37582435
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivityQ37583668
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.Q37588539
Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscleQ37590986
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.Q37629041
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.Q37736322
Insulin and its analogues and their affinities for the IGF1 receptor.Q37993843
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndromeQ38312576
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.Q39100111
AKT/PKB Signaling: Navigating the NetworkQ39255027
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.Q39331294
AMPK as a Therapeutic Target for Treating Metabolic DiseasesQ39396294
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activationQ39697365
AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPaseQ39787435
A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanismQ39966490
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesQ40250572
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cellsQ40515180
Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesisQ40643912
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).Q40799734
Bavachalcone-induced manganese superoxide dismutase expression through the AMP-activated protein kinase pathway in human endothelial cellsQ41232659
The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells.Q42098498
AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent mannerQ42505826
Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.Q42701436
AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer.Q43091920
Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis.Q43238697
A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.Q43298108
Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activationQ43833571
Signaling pathways mediating phosphorylation and inactivation of glycogen synthase kinase-3β by the recombinant human δ-opioid receptor stably expressed in Chinese hamster ovary cells.Q44349226
The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK PhosphorylationQ44405235
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cellsQ44468960
Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complexQ44473651
Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.Q44628501
Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177.Q46508470
Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.Q46731659
A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptakeQ46903583
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
Obesity, type 2 diabetes, and impaired insulin-stimulated blood flow: role of skeletal muscle NO synthase and endothelin-1.Q50333291
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)3886
P577publication date2018-12-05
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleA769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase
P478volume19

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cites work (P2860)
Q64018902AMP-Activated Protein Kinase Signalling
Q92290058The Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities

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