Autophagy and metabolic changes in obesity-related chronic kidney disease

scientific article published on 30 July 2013

Autophagy and metabolic changes in obesity-related chronic kidney disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NDT/GFT229
P932PMC publication ID3814227
P698PubMed publication ID23901047

P2093author name stringKumar Sharma
Joseph Satriano
P2860cites workObesity and Risk for Chronic Renal FailureQ22241459
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1Q24300456
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient miceQ24303752
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagyQ24316492
Adiponectin regulates albuminuria and podocyte function in miceQ24324384
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetesQ24656627
Mechanisms of mitophagyQ27310261
Autophagy fights disease through cellular self-digestionQ27860902
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domainsQ28114920
Prevalence of overweight and obesity in the United States, 1999-2004Q28305811
The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolismQ28512608
Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitusQ28564315
Autophagy regulates lipid metabolismQ29547421
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Termination of autophagy and reformation of lysosomes regulated by mTORQ29619817
Role of mTOR in podocyte function and diabetic nephropathy in humans and miceQ30500731
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.Q33896647
Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetesQ33959129
Altered lipid content inhibits autophagic vesicular fusionQ34017069
Chaperone-mediated autophagy in protein quality controlQ34150995
AMPKalpha1 regulates the antioxidant status of vascular endothelial cellsQ47801068
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.Q51057544
AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.Q53500309
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.Q53616050
The epidemiology of obesityQ57196005
Functional and structural changes in the kidney in the early stages of obesityQ73928010
Prevention of obesity-linked renal disease: age-dependent effects of dietary food restrictionQ74351905
Rapamycin prevents early steps of the development of diabetic nephropathy in ratsQ80726615
Altered autophagy in human adipose tissues in obesityQ82295529
Autophagy: a protective mechanism against nephrotoxicant-induced renal injuryQ83016434
Obesity and chronic kidney diseaseQ84219086
Microautophagy: lesser-known self-eatingQ34232209
Autophagy: basic principles and relevance to diseaseQ34585381
Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathwayQ35213340
Fatty acids suppress autophagic turnover in β-cellsQ35604849
Pexophagy: the selective degradation of peroxisomesQ35872257
Emerging role of autophagy in kidney function, diseases and agingQ36194753
Sirtuins and renal diseases: relationship with aging and diabetic nephropathyQ36304756
Kidney growth during catabolic illness: what it does not destroy makes it grow stronger.Q36803027
Association between obesity and kidney disease: a systematic review and meta-analysisQ36967756
Recycle or die: the role of autophagy in cardioprotection.Q37114188
Risk factors for end-stage renal disease: 25-year follow-upQ37307169
Autophagy genes and ageingQ37349831
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesisQ37446431
Weight loss and proteinuria: systematic review of clinical trials and comparative cohorts.Q37640916
Autophagy: an adaptable modifier of tumourigenesisQ37676660
Autophagy and adipogenesis: implications in obesity and type II diabetesQ37683310
Regulation of autophagy by ROS: physiology and pathologyQ37781565
Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardiumQ37826367
Implications of autophagy for glomerular aging and diseaseQ37834371
Autophagy as a therapeutic target in diabetic nephropathyQ37949588
Autophagy: a novel therapeutic target for kidney diseasesQ38042825
Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in miceQ38330390
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.Q38666713
Spatial coupling of mTOR and autophagy augments secretory phenotypes.Q39554934
Sirolimus and proteinuria in renal transplant patients: evidence for a dose-dependent effect on slit diaphragm-associated proteins.Q39583588
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging miceQ39812158
Endoplasmic reticulum stress induces autophagy in renal proximal tubular cellsQ39849425
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.Q39878605
Inhibition of MTOR disrupts autophagic flux in podocytesQ41812610
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in miceQ41912848
Autophagy: roles in obesity-induced ER stress and adiponectin downregulation in adipocytesQ42009315
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.Q42491649
Autophagy in aging, disease and death: the true identity of a cell death impostorQ42609173
Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistanceQ42797937
Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1.Q42807283
Cholesterol depletion induces autophagyQ42834297
Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?Q43293883
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cellsQ44468960
The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential.Q46021736
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
autophagyQ288322
P304page(s)iv29-36
P577publication date2013-07-30
P1433published inNephrology Dialysis TransplantationQ15710302
P1476titleAutophagy and metabolic changes in obesity-related chronic kidney disease
P478volume28 Suppl 4

Reverse relations

cites work (P2860)
Q54951434Advanced oxidation protein products inhibit the autophagy of renal tubular epithelial cells.
Q46312225Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential
Q55069288Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers.
Q47144150High Endogenous Accumulation of ω-3 Polyunsaturated Fatty Acids Protect against Ischemia-Reperfusion Renal Injury through AMPK-Mediated Autophagy in Fat-1 Mice
Q42945769Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling.
Q38266793Mechanisms and biological functions of autophagy in diseased and ageing kidneys.
Q24296638NRBF2 regulates macroautophagy as a component of Vps34 Complex I
Q42371719Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules
Q92812275PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice
Q26765293Role of autophagy in chronic kidney diseases
Q47831395Targeting Cellular Stress Mechanisms and Metabolic Homeostasis by Chinese Herbal Drugs for Neuroprotection.
Q28269939Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES

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