| scholarly article | Q13442814 |
| P50 | author | Ian P Salt | Q56876361 |
| P2093 | author name string | Timothy M Palmer | |
| P2860 | cites work | Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation | Q46504666 |
| AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function | Q46693950 | ||
| Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells. | Q46837274 | ||
| AMPKalpha1 regulates the antioxidant status of vascular endothelial cells | Q47801068 | ||
| 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction | Q48498646 | ||
| Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase. | Q50526646 | ||
| Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models. | Q51541906 | ||
| Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. | Q54573825 | ||
| 5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation | Q57800666 | ||
| Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding | Q22253261 | ||
| Structure of mammalian AMPK and its regulation by ADP | Q24296973 | ||
| Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase | Q24309462 | ||
| The ancient drug salicylate directly activates AMP-activated protein kinase | Q24630758 | ||
| mTOR: from growth signal integration to cancer, diabetes and ageing | Q24633662 | ||
| Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site | Q24645338 | ||
| Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation | Q24653742 | ||
| The selectivity of protein kinase inhibitors: a further update | Q24654622 | ||
| AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function | Q26865723 | ||
| Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells | Q27335298 | ||
| Immunity, Inflammation, and Cancer | Q27861048 | ||
| Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. | Q28118359 | ||
| Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase | Q28215845 | ||
| Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs | Q28246959 | ||
| Lymphocytes Accelerate Epithelial Tight Junction Assembly: Role of AMP-Activated Protein Kinase (AMPK) | Q28475263 | ||
| Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase | Q28567006 | ||
| Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist | Q28569816 | ||
| Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3) | Q28583520 | ||
| Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group | Q29547282 | ||
| Obesity induces a phenotypic switch in adipose tissue macrophage polarization | Q29547686 | ||
| 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? | Q29618095 | ||
| AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. | Q32043995 | ||
| Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans | Q32774312 | ||
| Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro | Q33249851 | ||
| Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells | Q33322641 | ||
| Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation | Q33346919 | ||
| Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16 | Q33602223 | ||
| Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo | Q33675689 | ||
| AMPK and SIRT1: a long-standing partnership? | Q33783499 | ||
| Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1 | Q33911210 | ||
| Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state | Q33968008 | ||
| Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. | Q34043189 | ||
| AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes | Q34059872 | ||
| Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase | Q34236772 | ||
| Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis | Q34247703 | ||
| Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials | Q34263014 | ||
| Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. | Q34311558 | ||
| Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. | Q34438345 | ||
| Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation | Q34438754 | ||
| The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. | Q34522920 | ||
| Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions | Q34784602 | ||
| Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation | Q35172021 | ||
| Elevated NF-κB activation is conserved in human myocytes cultured from obese type 2 diabetic patients and attenuated by AMP-activated protein kinase | Q35405108 | ||
| The liver kinase B1 is a central regulator of T cell development, activation, and metabolism | Q35500559 | ||
| Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity | Q35578618 | ||
| Clinical use of aspirin in treatment and prevention of cardiovascular disease | Q35609014 | ||
| IKK biology | Q35848596 | ||
| Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. | Q36877369 | ||
| Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes | Q36975445 | ||
| Smac mimetics and TNFalpha: a dangerous liaison? | Q37005632 | ||
| Signalling of toll-like receptors. | Q37028817 | ||
| MAPKs and their relevance to arthritis and inflammation | Q37054686 | ||
| Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression | Q37163458 | ||
| Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype | Q37372606 | ||
| The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. | Q37374914 | ||
| Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis. | Q37402798 | ||
| TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes | Q37416269 | ||
| Targeting IL-6 in the treatment of inflammatory and autoimmune diseases | Q37588720 | ||
| Overview of TNF superfamily: a chest full of potential therapeutic targets | Q37598561 | ||
| Targeting TNF for Treatment of Cancer and Autoimmunity | Q37598563 | ||
| A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. | Q37652443 | ||
| Control of NF-kappaB-dependent transcriptional responses by chromatin organization | Q37672298 | ||
| Actual status of antiinterleukin-1 therapies in rheumatic diseases | Q37691204 | ||
| TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer | Q37948115 | ||
| Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome | Q38312576 | ||
| NF-kappaB signals induce the expression of c-FLIP. | Q39460566 | ||
| AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. | Q39469473 | ||
| AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3). | Q39676938 | ||
| Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation | Q39697365 | ||
| Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner | Q39707409 | ||
| Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. | Q39738771 | ||
| Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion | Q39773528 | ||
| Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression | Q39960657 | ||
| Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity. | Q40051802 | ||
| NOS2 regulation of NF-kappaB by S-nitrosylation of p65. | Q40089315 | ||
| 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. | Q40130482 | ||
| Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase | Q40227253 | ||
| 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages | Q40560732 | ||
| Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells | Q42170618 | ||
| 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved. | Q42274638 | ||
| α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation | Q42482105 | ||
| Aspirin-induced AMP-activated protein kinase activation regulates the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats | Q42487112 | ||
| The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment | Q42593305 | ||
| Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation | Q42725397 | ||
| Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. | Q42767129 | ||
| Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. | Q42783350 | ||
| Berberine suppresses proinflammatory responses through AMPK activation in macrophages | Q42803322 | ||
| AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis | Q42924913 | ||
| Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. | Q43123382 | ||
| Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis. | Q43125942 | ||
| The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression | Q43211202 | ||
| Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells | Q44468960 | ||
| 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. | Q44728727 | ||
| AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise | Q44953597 | ||
| AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. | Q45123854 | ||
| Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. | Q46236023 | ||
| Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase | Q46359191 | ||
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | inflammation | Q101991 |
| P304 | page(s) | 1155-1167 | |
| P577 | publication date | 2012-06-14 | |
| P1433 | published in | Expert Opinion on Investigational Drugs | Q5421208 |
| P1476 | title | Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation | |
| P478 | volume | 21 |
| Q40644641 | 5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis |
| Q51426480 | A concise review on advances in development of small molecule anti-inflammatory therapeutics emphasising AMPK: An emerging target. |
| Q37170305 | A marriage of two "Methusalem" drugs for the treatment of psoriasis?: Arguments for a pilot trial with metformin as add-on for methotrexate. |
| Q39331294 | AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System. |
| Q40423409 | AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis |
| Q47369070 | AMPK and cardiac remodelling. |
| Q37582435 | Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation |
| Q54116484 | Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice. |
| Q46592595 | Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia |
| Q34444895 | Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease |
| Q38919873 | Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase |
| Q90400166 | Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation |
| Q41900013 | CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models |
| Q54119005 | Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. |
| Q39354303 | Cellular stress response mechanisms as therapeutic targets of ginsenosides |
| Q55274553 | Cellular stress response mechanisms of Rhizoma coptidis: a systematic review. |
| Q36985220 | Effects of an High-Fat Diet Enriched in Lard or in Fish Oil on the Hypothalamic Amp-Activated Protein Kinase and Inflammatory Mediators |
| Q41536841 | Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis |
| Q37745507 | Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis |
| Q37655435 | Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells |
| Q38770370 | Globular CTRP9 inhibits oxLDL-induced inflammatory response in RAW 264.7 macrophages via AMPK activation |
| Q35532304 | Glycolytic switch in response to betulinic acid in non-cancer cells |
| Q47925960 | Green tea extract intake during lactation modified cardiac macrophage infiltration and AMP-activated protein kinase phosphorylation in weanling rats from undernourished mother during gestation and lactation |
| Q35008532 | Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice |
| Q52659506 | Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation. |
| Q112652083 | Impaired phosphocreatine metabolism in white adipocytes promotes inflammation |
| Q28830573 | Inhibition of Extracellular Calcium Influx Results in Enhanced IL-12 Production in LPS-Treated Murine Macrophages by Downregulation of the CaMKKβ-AMPK-SIRT1 Signaling Pathway |
| Q92406823 | Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review |
| Q38882099 | Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease. |
| Q58730141 | LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling |
| Q58743656 | METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice |
| Q35034808 | Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice |
| Q37582441 | Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms |
| Q39721653 | Metformin use and asthma outcomes among patients with concurrent asthma and diabetes |
| Q37440481 | Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury |
| Q61814335 | Milk From Cow Fed With High Forage/Concentrate Ratio Diet: Beneficial Effect on Rat Skeletal Muscle Inflammatory State and Oxidative Stress Through Modulation of Mitochondrial Functions and AMPK Activity |
| Q38093566 | Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities |
| Q50000505 | Molecular action of isoflavone genistein in the human epithelial cell line HaCaT. |
| Q99579029 | Non-cytotoxic doses of shikonin inhibit lipopolysaccharide-induced TNF-α expression via activation of the AMP-activated protein kinase signaling pathway |
| Q39226865 | Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases |
| Q90639945 | Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation |
| Q35163421 | Obesity and asthma in children: current and future therapeutic options |
| Q37488514 | Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. |
| Q89475466 | Quzhou Fructus Aurantii Extract suppresses inflammation via regulation of MAPK, NF-κB, and AMPK signaling pathway |
| Q43941554 | Regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytes |
| Q36933430 | Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue |
| Q41516789 | Searching for biomarkers of comorbidities in sera of treated HIV-infected patients by isoelectric focusing |
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