AMPK and the biochemistry of exercise: implications for human health and disease

scientific article published on March 2009

AMPK and the biochemistry of exercise: implications for human health and disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ20082055
P932PMC publication ID2779044
P698PubMed publication ID19196246

P50authorNeil B RudermanQ43064674
P2093author name stringErik A Richter
P2860cites workComplexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeQ21245891
Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 DiabetesQ22241283
Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or MetforminQ22250892
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemiaQ24290495
Structural basis for AMP binding to mammalian AMP-activated protein kinaseQ24293456
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activationQ24321658
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivationQ24541475
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivityQ24554361
Isoform-specific and exercise intensity-dependent activation of 5'-AMP-activated protein kinase in human skeletal muscleQ24651012
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3Q24672153
Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1Q24683047
Resveratrol improves health and survival of mice on a high-calorie dietQ27860950
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exerciseQ28139373
Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscleQ64377743
A prospective study of exercise and incidence of diabetes among US male physiciansQ68160392
Muscle carnitine metabolism during incremental dynamic exercise in humansQ68756817
Muscle malonyl-CoA decreases during exerciseQ69362170
Muscle alpha-aminoisobutyric acid transport after exercise: enhanced stimulation by insulinQ69891429
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesisQ69907652
Treadmill training improves intravenous glucose tolerance and insulin sensitivity in fatty Zucker ratsQ70253641
Effect of physical exercise on sensitivity and responsiveness to insulin in humansQ70380200
Protein synthesis versus energy state in contracting muscles of perfused rat hindlimbQ71345508
Impairment of peripheral glucose utilization in normal subjects by prolonged bed restQ71477066
Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy menQ72135115
Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscleQ74102298
AMP-activated protein kinase phosphorylation of endothelial NO synthaseQ74456171
Malonyl CoA as a metabolic switch and a regulator of insulin sensitivityQ77440830
Liver AMP-activated protein kinase and acetyl-CoA carboxylase during and after exerciseQ77945919
Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscleQ79233726
Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activationQ79743582
Does the metabolic syndrome exist?Q79793016
Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscleQ79801118
Effect of sex differences on human MEF2 regulation during endurance exerciseQ80097640
Why muscle stops building when it's workingQ81321809
Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal MuscleQ58449848
Functional role of AMP-activated protein kinase in the heart during exerciseQ59607761
Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscleQ60727708
Lack of AMPKα2 enhances pyruvate dehydrogenase activity during exerciseQ64018947
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose toleranceQ28186874
A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscleQ28199222
5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscleQ28208928
Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exerciseQ28212929
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesisQ28218978
AMP-activated protein kinase plays a role in the control of food intakeQ28240521
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamusQ28254114
What makes vessels grow with exercise training?Q28279253
The effects of increasing exercise intensity on muscle fuel utilisation in humansQ28360649
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinaseQ28567006
Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytesQ28570462
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exerciseQ28581480
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2Q28582345
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosisQ28583941
LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoformsQ28646530
Calorie restriction increases muscle mitochondrial biogenesis in healthy humansQ28763406
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) GroupQ29547282
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes StudyQ29615122
Sirtuins in mammals: insights into their biological functionQ29615248
Metformin and reduced risk of cancer in diabetic patientsQ29616275
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismQ29617261
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energyQ29618101
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alphaQ29620443
AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscleQ33332145
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response studyQ33747784
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contractionQ33841869
Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscleQ33880419
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscleQ33905083
Analysis of the role of the AMP-activated protein kinase in the response to cellular stress.Q33979128
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trialQ33999757
Protein and amino acid metabolism during and after exercise and the effects of nutrition.Q34001489
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trialQ34013637
Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.Q34100394
Lipotoxic diseasesQ34111950
Functions of AMP-activated protein kinase in adipose tissue.Q36482345
Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognitionQ36662190
Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndromeQ36666161
Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscleQ36673063
AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevanceQ36711158
The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trialQ36825706
Capitalizing on cortical plasticity: influence of physical activity on cognition and brain functionQ36880678
Activity-dependent signaling pathways controlling muscle diversity and plasticityQ36910755
Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of miceQ36943709
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.Q37005641
Contraction-stimulated glucose transport in rat skeletal muscle is sustained despite reversal of increased PAS-phosphorylation of AS160 and TBC1D1Q37033515
Systemic and mitochondrial adaptive responses to moderate exercise in rodentsQ37055818
LKB1 and AMPK in cell polarity and divisionQ37100013
Physical activity and cancer prevention : pathways and targets for interventionQ37112886
5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) miceQ38292086
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathwaysQ38316513
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonistsQ38318111
Structural basis for glycogen recognition by AMP-activated protein kinaseQ38320088
Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.Q38333574
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.Q39252731
Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.Q39646969
Decrease in Akt/PKB signalling in human skeletal muscle by resistance exerciseQ39974546
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinaseQ39981968
Adaptations of skeletal muscle to endurance exercise and their metabolic consequencesQ40178125
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient miceQ40250591
Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulinQ40680853
SIRT1 controls endothelial angiogenic functions during vascular growthQ41112118
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascadeQ42160057
Interleukin-6 stimulates lipolysis and fat oxidation in humansQ42169595
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO productionQ42269153
The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscleQ42464408
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.Q42468549
Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.Q42490447
Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defectsQ42498869
Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscleQ42500929
A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolismQ42507613
AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36.Q42508162
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscleQ42516404
Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans.Q42542026
Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exerciseQ42556342
Evidence for the regulation of contraction-induced fatty acid oxidation via extracellular signal-regulated kinase 1/2 activation independent of changes in fatty acid uptakeQ42628963
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissueQ42809801
AMP-activated protein kinase activity and glucose uptake in rat skeletal muscleQ43565211
Dysfunctional regulation of endothelial nitric oxide synthase (eNOS) expression in response to exercise in mice lacking one eNOS geneQ43636915
Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulinQ43819485
Skeletal muscle eEF2 and 4EBP1 phosphorylation during endurance exercise is dependent on intensity and muscle fiber typeQ43827533
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetesQ43833528
Interleukin-6-deficient mice develop mature-onset obesityQ43851625
Myocellular triacylglycerol breakdown in females but not in males during exerciseQ43879200
Progressive increase in human skeletal muscle AMPKalpha2 activity and ACC phosphorylation during exerciseQ43879217
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndromeQ44043225
Cardiorespiratory fitness as a predictor of cancer mortality among men with pre-diabetes and diabetesQ44044328
AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed ratsQ44155454
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscleQ44253307
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetesQ44418692
Physiological role of AMP-activated protein kinase in the heart: graded activation during exerciseQ44448758
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cellsQ44468960
AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitionsQ44482243
Effect of exercise intensity on skeletal muscle AMPK signaling in humansQ44564007
Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.Q44628501
Exercise training blunts microvascular rarefaction in the metabolic syndrome.Q44921311
Muscle-derived interleukin-6: mechanisms for activation and possible biological rolesQ34146938
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocationQ34183649
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.Q34196949
Management of cellular energy by the AMP-activated protein kinase systemQ34209246
Insulin and glucose responses during bed rest with isotonic and isometric exerciseQ34244665
AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetesQ34268235
5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscleQ34276280
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndromeQ34310675
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.Q34311558
AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscleQ34406367
AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance-trained rats.Q34422776
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.Q34438345
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscleQ34452979
Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscleQ34487740
Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective studyQ34505481
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restrictionQ34534198
Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in miceQ34559719
AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humansQ34578245
Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shiftQ34629944
Invited review: effect of acute exercise on insulin signaling and action in humansQ34691758
Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'.Q35053068
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cellsQ35218922
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrusQ35720477
Resveratrol stimulates AMP kinase activity in neuronsQ35758555
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathwayQ35768634
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthaseQ35990346
AMPK, the metabolic syndrome and cancerQ36024356
Skeletal muscle glucose uptake during exercise: how is it regulated?Q36197831
Physical inactivity is a diseaseQ36252878
Neuronal protection by sirtuins in Alzheimer's diseaseQ36283826
Obesity and the role of adipose tissue in inflammation and metabolismQ36392619
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disordersQ36462591
Neurobiology of exerciseQ36464136
Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exerciseQ36475851
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exerciseQ44953597
Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise.Q45016706
Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunitQ45032346
AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese femalesQ45050639
Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exerciseQ45071070
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.Q45161288
Exercise in rats does not alter hypothalamic AMP-activated protein kinase activityQ45287352
Physical fitness and all-cause mortality. A prospective study of healthy men and womenQ45817114
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.Q45915520
The alpha-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitroQ46350761
Long-term AICAR administration and exercise prevents diabetes in ZDF ratsQ46406504
Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.Q46477223
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.Q46495742
Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscleQ46538551
Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscleQ46543180
Metabolic responses to reduced daily steps in healthy nonexercising men.Q46694928
AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscleQ46722194
Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient miceQ46728828
Nutritional status, cognition, and survival: a new role for leptin and AMP kinaseQ46734993
Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of ratsQ46761363
Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exerciseQ46817331
Exercise training promotes SIRT1 activity in aged rats.Q46857793
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulinQ46917157
Absence of humoral mediated 5'AMP-activated protein kinase activation in human skeletal muscle and adipose tissue during exercise.Q46930517
Seven days of bed rest decrease insulin action on glucose uptake in leg and whole bodyQ46970750
Effect of weight loss on muscle fiber type, fiber size, capillarity, and succinate dehydrogenase activity in humansQ47253321
Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity.Q47668219
Reduced exercise endurance in interleukin-6-deficient miceQ48013970
Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar ratsQ48435774
Exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic ratsQ48524791
Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscleQ48546278
Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinaseQ50337120
Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model-.Q51756025
AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.Q52573139
Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase.Q53547602
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle.Q53608576
Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise.Q54095949
Long-term exercise stimulates adenosine monophosphate-activated protein kinase activity and subunit expression in rat visceral adipose tissue and liver.Q54592325
AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory SubunitsQ57274206
Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranosideQ58088416
Exercise diminishes the activity of acetyl-CoA carboxylase in human muscleQ58108348
Caffeine-induced Ca2+ release increases AMPK-dependent glucose uptake in rodent soleus muscleQ58172060
Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscleQ58172078
Muscle metabolism during graded quadriceps exercise in manQ58172093
Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contractionQ58172102
Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exerciseQ58172137
Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of menQ58172158
IMP metabolism in human skeletal muscle after exhaustive exerciseQ58172456
Effect of exercise on insulin action in human skeletal muscleQ58172564
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)261-275
P577publication date2009-03-01
P1433published inBiochemical JournalQ864221
P1476titleAMPK and the biochemistry of exercise: implications for human health and disease
P478volume418

Reverse relations

cites work (P2860)
Q515961465'-AMP activated protein kinase α2 controls substrate metabolism during post-exercise recovery via regulation of pyruvate dehydrogenase kinase 4.
Q415084065'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat.
Q50478355A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.
Q36815297A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats
Q91776028A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity
Q38977667A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties.
Q34381237A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Q33688657AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity?
Q35229081AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.
Q36756228AMP-activated protein kinase and its downstream transcriptional pathways
Q37856788AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
Q28480896AMP-activated protein kinase plays an important evolutionary conserved role in the regulation of glucose metabolism in fish skeletal muscle cells
Q24610297AMP-activated protein kinase, stress responses and cardiovascular diseases
Q33824564AMPK activation: a therapeutic target for type 2 diabetes?
Q33783499AMPK and SIRT1: a long-standing partnership?
Q34720569AMPK and insulin action--responses to ageing and high fat diet
Q33789079AMPK as a metabolic tumor suppressor: control of metabolism and cell growth
Q37657974AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice
Q36966839AMPK, insulin resistance, and the metabolic syndrome
Q33874648Abdominal obesity: causal factor or simply a symptom of obesity-related health risk
Q27310085Abnormalities of AMPK activation and glucose uptake in cultured skeletal muscle cells from individuals with chronic fatigue syndrome
Q38549546Activation of AMPK and its Impact on Exercise Capacity
Q28482314Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes
Q36178191Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4.
Q93048487Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise
Q42475257Autophagic adaptation is associated with exercise-induced fibre-type shifting in skeletal muscle.
Q26772690Barth Syndrome: From Mitochondrial Dysfunctions Associated with Aberrant Production of Reactive Oxygen Species to Pluripotent Stem Cell Studies
Q43059644Cafeteria diet-induced insulin resistance is not associated with decreased insulin signaling or AMPK activity and is alleviated by physical training in rats
Q54977465Capsaicinoids improve consequences of physical activity.
Q37523452Chronic Exercise Training Improved Aortic Endothelial and Mitochondrial Function via an AMPKα2-Dependent Manner
Q39435905Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer
Q64376771Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells
Q37864394Control of nuclear receptor activities in metabolism by post-translational modifications
Q28395897Creatine-kinase- and exercise-related muscle damage implications for muscle performance and recovery
Q93155715Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1
Q47907358Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease
Q46575557Decline of cell viability and mitochondrial activity in mouse skeletal muscle cell in a hypomagnetic field
Q28070199Does Habitual Physical Activity Increase the Sensitivity of the Appetite Control System? A Systematic Review
Q35757070Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle
Q34567216Effect of Walking Exercise on Changes in Cardiorespiratory Fitness, Metabolic Syndrome Markers, and High-molecular-weight Adiponectin in Obese Middle-aged Women
Q33506469Effect of exercise on disorders of carbohydrate and lipid metabolism in adults with traumatic spinal cord injury: systematic review of the evidence
Q48044379Effects of 6-month aerobic interval training on skeletal muscle metabolism in middle-aged metabolic syndrome patients
Q35910951Effects of Mung Bean (Vigna radiata L.) Ethanol Extracts Decrease Proinflammatory Cytokine-Induced Lipogenesis in the KK-Ay Diabese Mouse Model
Q64778284Effects of Preventive Treadmill Exercise on the Recovery of Metabolic and Mitochondrial Factors in the 6-Hydroxydopamine Rat Model of Parkinson's Disease
Q34525549Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes
Q47237475Effects of topical capsaicin combined with moderate exercise on insulin resistance, body weight and oxidative stress in hypoestrogenic obese rats.
Q33598389Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle
Q27307073Electrical pulse stimulation of cultured human skeletal muscle cells as an in vitro model of exercise
Q58705798Endocrine Crosstalk Between Skeletal Muscle and the Brain
Q35589856Endurance training inhibits insulin clearance and IDE expression in Swiss mice
Q37629041Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.
Q36339569Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4.
Q43239564Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide
Q99416008Exercise immunology: Future directions
Q53266561Exercise type and volume alter signaling pathways regulating skeletal muscle glucose uptake and protein synthesis.
Q92127887Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension
Q54396964Exercise-induced expression of peroxisome proliferator-activated receptor γ coactivator-1α isoforms in skeletal muscle of endurance-trained males.
Q38980340Exercise-stimulated glucose uptake - regulation and implications for glycaemic control
Q43094322Exercising insulin sensitivity: AMPK turns on autophagy!
Q57675707Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a 6-month exercise intervention
Q37767671Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease.
Q87447906Forkhead BoxO transcription factors restrain exercise-induced angiogenesis
Q42801551Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss.
Q37198711Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials.
Q39223093From apelin to exercise: emerging therapies for management of hypertension in pregnancy
Q36253720Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.
Q51722308Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKα2.
Q37095413Glycogen and its metabolism: some new developments and old themes
Q54250681Greater basal skeletal muscle AMPKα phosphorylation in men than in women: Associations with anaerobic performance.
Q42117438Hepatic energy state is regulated by glucagon receptor signaling in mice
Q98613061High intensity exercise downregulates FTO mRNA expression during the early stages of recovery in young males and females
Q55068293Human muscle fibre type-specific regulation of AMPK and downstream targets by exercise.
Q42245821IL-6 indirectly modulates the induction of glyceroneogenic enzymes in adipose tissue during exercise
Q56240296IL-6 regulates exercise and training-induced adaptations in subcutaneous adipose tissue in mice
Q91639058Icariin treatment reduces blood glucose levels in type 2 diabetic rats and protects pancreatic function
Q52841559Individual variability in compensatory eating following acute exercise in overweight and obese women.
Q26777620Inflammation and intracellular metabolism: new targets in OA
Q36795983LKB1 regulates lipid oxidation during exercise independently of AMPK
Q34560916Lack of exercise is a major cause of chronic diseases
Q34448802Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
Q41885927Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
Q91790804Long-Term Moderate Exercise Combined with Metformin Treatment Induces an Hormetic Response That Prevents Strength and Muscle Mass Loss in Old Female Wistar Rats
Q24617747Metformin activates AMP kinase through inhibition of AMP deaminase
Q90477678Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults
Q54508172Metformin interacts with AMPK through binding to γ subunit.
Q43063833Metformin, cancer, alphabet soup, and the role of epidemiology in etiologic research
Q99414054Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes
Q36320932Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet
Q59132572Mitochondrial targeting as a novel therapy for stroke
Q98947491Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19
Q38111713Molecular mechanisms of muscle plasticity with exercise
Q38549528Multi-target drugs to address multiple checkpoints in complex inflammatory pathologies: evolutionary cues for novel "first-in-class" anti-inflammatory drug candidates: a reviewer's perspective.
Q45930153Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle.
Q38730157Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent
Q45968038Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice.
Q38095853Nitric oxide and energy metabolism in mammals
Q54217434No effect of dietary nitrate supplementation on endurance training in hypoxia.
Q37528136Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with 'exercise mimetics'.
Q34030453PGC-1α and exercise in the control of body weight.
Q36674635PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells
Q51733417Performance during a strenuous swimming session is associated with high blood lactate: pyruvate ratio and hypoglycemia in fasted rats.
Q36560523Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db mice
Q64097637Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
Q39117162Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle
Q36702291Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes.
Q34758958Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease
Q36298471Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise
Q42794498Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide
Q55715015Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training.
Q34460342Regular exercise is associated with a reduction in the risk of NAFLD and decreased liver enzymes in individuals with NAFLD independent of obesity in Korean adults
Q37978302Regulation and limitations to fatty acid oxidation during exercise
Q37697191Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor γ coactivator 1α.
Q41061610Research of influence and mechanism of combining exercise with diet control on a model of lipid metabolism rat induced by high fat diet
Q37679183Resistance training to improve type 2 diabetes: working toward a prescription for the future
Q50482344Role of exercise duration on metabolic adaptations in working muscle to short-term moderate-to-heavy aerobic-based cycle training.
Q33862222Role of exercise in maintaining the integrity of the neuromuscular junction
Q27000731Role of lipotoxicity in endothelial dysfunction
Q38128640Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism
Q37815730SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model
Q48002642SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK.
Q35192248Single muscle fiber proteomics reveals unexpected mitochondrial specialization
Q41057061Sirt6 alters adult hippocampal neurogenesis
Q60951291Skeletal Muscle Mitochondrial Protein Synthesis and Respiration Increase With Low-Load Blood Flow Restricted as Well as High-Load Resistance Training
Q40967296Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression
Q27680957Structural basis of AMPK regulation by small molecule activators
Q34100394Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.
Q89959094Supplementing conjugated and non-conjugated L-methionine and acetate alters expression patterns of CSN2, proteins and metabolites related to protein synthesis in bovine mammary cells
Q28584878Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle
Q36171138Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
Q42426461Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes
Q38606849Targeting of cell metabolism in human acute myeloid leukemia--more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?
Q36038197The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.
Q33705451The Crosstalk between the Gut Microbiota and Mitochondria during Exercise
Q37337283The Randle cycle revisited: a new head for an old hat.
Q51553127The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle.
Q34658544The many ways to regulate glucose transporter 4.
Q37880062The relationship between substrate metabolism, exercise and appetite control: does glycogen availability influence the motivation to eat, energy intake or food choice?
Q46978063The role of declining adaptive homeostasis in ageing
Q43007275Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle
Q33899674Treadmill exercise ameliorates the regulation of energy metabolism in skeletal muscle of NSE/PS2m-transgenic mice with Alzheimer's disease
Q26753111Understanding Muscle Dysfunction in Chronic Fatigue Syndrome
Q90420426Understanding the Role of Dysfunctional and Healthy Mitochondria in Stroke Pathology and Its Treatment
Q38810023Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights
Q35146002Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.
Q30355011Voluntary Exercise Improves Estrous Cyclicity in Prenatally Androgenized Female Mice Despite Programming Decreased Voluntary Exercise: Implications for Polycystic Ovary Syndrome (PCOS).
Q34333517Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.
Q26824357You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging

Search more.