Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise

scientific article

Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.2006.109942
P932PMC publication ID1817795
P698PubMed publication ID16690705
P5875ResearchGate publication ID7090099

P50authorJørgen WojtaszewskiQ57339852
P2093author name stringErik A Richter
Sebastian B Jørgensen
P2860cites work5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanismsQ71824256
Role of the AMP-activated protein kinase in the cellular stress responseQ72707925
Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activatedQ73221656
Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocaseQ73754975
Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscleQ74102298
Muscle phosphorylase kinase is not a substrate of AMP-activated protein kinaseQ74152034
Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscleQ77520349
Why muscle stops building when it's workingQ81321809
Glycogen and its MetabolismQ22305786
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domainQ24296738
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivationQ24541475
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutationsQ24614590
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory siteQ24645338
Isoform-specific and exercise intensity-dependent activation of 5'-AMP-activated protein kinase in human skeletal muscleQ24651012
Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase SignalingQ27832095
TSC2 mediates cellular energy response to control cell growth and survivalQ27860970
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Q28131760
Molecular mechanisms regulating hormone-sensitive lipase and lipolysisQ28187666
A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscleQ28199222
Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exerciseQ28212929
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseQ28215845
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signalingQ28216932
Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscleQ28217883
AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contractionQ45152742
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.Q45161288
Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylaseQ45173478
Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activityQ45199120
Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans.Q45261139
5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes.Q45271639
ERK1/2 inhibition prevents contraction-induced increase in plasma membrane FAT/CD36 content and FA uptake in rodent muscleQ46239218
Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.Q46477223
AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscleQ46722194
Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of ratsQ46761363
Evidence against regulation of AMP-activated protein kinase and LKB1/STRAD/MO25 activity by creatine phosphate.Q46797064
Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transportQ47690623
Cloning and characterization of mouse 5′-AMP-activated protein kinase γ3 subunitQ48226599
Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles.Q53668959
The regulation of carbohydrate and fat metabolism during and after exercise.Q55067945
Oral glucose ingestion attenuates exercise-induced activation of 5′-AMP-activated protein kinase in human skeletal muscleQ56240275
AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory SubunitsQ57274206
Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranosideQ58088416
Exercise diminishes the activity of acetyl-CoA carboxylase in human muscleQ58108348
Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exerciseQ58172137
Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of menQ58172158
Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanismQ59975365
Time course of exercise-induced decline in malonyl-CoA in different muscle typesQ68471725
The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinaseQ69370621
AMP deaminase binding in rat skeletal muscle after high-intensity runningQ70769590
Protein synthesis versus energy state in contracting muscles of perfused rat hindlimbQ71345508
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesisQ28218978
Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscleQ28238008
Skeletal muscle lipid metabolism in exercise and insulin resistanceQ28288218
Glucose, exercise and insulin: emerging conceptsQ28348687
5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenicsQ28511328
Functional properties of phosphorylated elongation factor 2Q28572074
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exerciseQ28581480
Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscleQ28581653
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2Q28582345
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exerciseQ28610612
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismQ29617261
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?Q29618095
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?Q29618125
The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysisQ29618429
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contractionQ33841869
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscleQ33869428
Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscleQ33880419
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscleQ33902357
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscleQ33905083
Protein and amino acid metabolism during and after exercise and the effects of nutrition.Q34001489
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesisQ34101012
Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).Q34122252
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocationQ34183649
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.Q34196949
AMPK beta subunit targets metabolic stress sensing to glycogenQ34196956
Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscleQ34269935
5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscleQ34276280
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.Q34311558
Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.Q34383662
AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance-trained rats.Q34422776
Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinaseQ34423699
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscleQ34452979
Energy supply and muscle fatigue in humansQ34467250
Nuclear activators and coactivators in mammalian mitochondrial biogenesisQ34657768
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.Q35041054
AMP-activated protein kinase, super metabolic regulatorQ35053000
Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'.Q35053068
The multifaceted role of mTOR in cellular stress responsesQ35848454
Exercise signalling to glucose transport in skeletal muscleQ35855908
Regulation of glycogen synthase activity and phosphorylation by exerciseQ35855925
Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signallingQ35855998
Skeletal muscle glucose uptake during exercise: how is it regulated?Q36197831
Contraction signaling to glucose transport in skeletal muscleQ36203847
Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.Q37537923
Adenine nucleotide degradation in striated muscleQ37936995
Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistinQ40378852
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinasesQ40404608
PPARγ coactivator-1α expression during thyroid hormone- and contractile activity-induced mitochondrial adaptationsQ40649637
Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell lineQ40767491
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.Q40998382
Molecular mechanisms for the control of translation by insulinQ41644481
Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle.Q41884196
Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinaseQ42435111
The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscleQ42464408
Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.Q42490447
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinaseQ42491855
Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipaseQ42512065
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscleQ42516404
Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR--an activator of AMP-activated protein kinaseQ42516526
Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans.Q42542026
Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exerciseQ42556342
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissueQ42809801
AMP-activated protein kinase activity and glucose uptake in rat skeletal muscleQ43565211
Regulation of muscle GLUT-4 transcription by AMP-activated protein kinaseQ43710036
Progressive increase in human skeletal muscle AMPKalpha2 activity and ACC phosphorylation during exerciseQ43879217
Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's diseaseQ44030427
AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscleQ44176909
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscleQ44253307
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetesQ44418692
Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinaseQ44493386
Effect of exercise intensity on skeletal muscle AMPK signaling in humansQ44564007
Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacityQ44575204
Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.Q44628501
Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscleQ44746401
Contractions induce phosphorylation of the AMPK site Ser565 in hormone-sensitive lipase in muscleQ44807019
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyteQ44907827
AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle.Q44912753
Regulation of plasma long-chain fatty acid oxidation in relation to uptake in human skeletal muscle during exerciseQ44928887
Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling.Q44961972
Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise.Q45016706
Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exerciseQ45071070
P433issuePt 1
P407language of work or nameEnglishQ1860
P921main subjectmetabolic adaptationQ47171912
P1104number of pages15
P304page(s)17-31
P577publication date2006-05-11
P1433published inJournal of PhysiologyQ7743612
P1476titleRole of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
P478volume574

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