Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure

scientific article published on 18 December 2008

Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.108.190918
P932PMC publication ID2709761
P698PubMed publication ID19096023

P50authorRong TianQ37839095
John CalvertQ42718453
P2093author name stringSaurabh Jha
Arun Ramachandran
David J Lefer
Susheel Gundewar
Sang Yong Ji
Denise Nunez
Iris Toedt-Pingel
Mauricio Anaya-Cisneros
P2860cites workMetformin: An UpdateQ22241145
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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivationQ24541475
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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) GroupQ29547282
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alphaQ29620443
Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.Q30359509
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial functionQ30480176
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinaseQ33965444
Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in miceQ34961540
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.Q35213694
The AMP-activated protein kinase pathway--new players upstream and downstream.Q35930365
The safety of metformin in heart failureQ36765255
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injuryQ37286204
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesisQ37526796
Mitochondrial biogenesis by NO yields functionally active mitochondria in mammalsQ37692490
Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetesQ38300037
Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto studyQ39839307
Attenuation of myocardial ischemia-reperfusion injury with nitric oxide replacement therapyQ40484144
Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injuryQ42873483
Metformin improves cardiac functional recovery after ischemia in ratsQ43978119
Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinaseQ44453273
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cellsQ44468960
Mitochondrial abnormalities in myocardium of dogs with chronic heart failureQ44576578
Signaling and expression for mitochondrial membrane proteins during left ventricular remodeling and contractile failure after myocardial infarctionQ44601934
Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitusQ44759159
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signalingQ46847423
Metformin in heart failureQ46879293
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.Q46952844
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscleQ47755014
Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathyQ68189721
Metformin improves cardiac function in isolated streptozotocin-diabetic rat heartsQ72324128
United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. United KingdQ74137575
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and diseaseQ80336398
P433issue3
P921main subjectmetforminQ19484
heart failureQ181754
P304page(s)403-411
P577publication date2008-12-18
P1433published inCirculation ResearchQ2599020
P1476titleActivation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
P478volume104

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