| scholarly article | Q13442814 |
| P50 | author | Denis M. Medeiros | Q55121986 |
| P2093 | author name string | Brian N Finck | |
| Daniel P Kelly | |||
| Denis M Medeiros | |||
| Jennifer G Duncan | |||
| Juliet L Fong | |||
| P2860 | cites work | PGC-1 coactivators: inducible regulators of energy metabolism in health and disease | Q24541524 |
| The continuing epidemics of obesity and diabetes in the United States | Q56890709 | ||
| Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivati | Q60636879 | ||
| Diabetic cardiomyopathy | Q69881084 | ||
| Activation of a novel metabolic gene regulatory pathway by chronic stimulation of skeletal muscle | Q71897650 | ||
| Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice | Q73127304 | ||
| The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis | Q24564869 | ||
| Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators | Q24652367 | ||
| Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 | Q24679555 | ||
| PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis | Q24798075 | ||
| Regulation of muscle fiber type and running endurance by PPARdelta | Q24799428 | ||
| A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders | Q28116120 | ||
| Superoxide activates mitochondrial uncoupling proteins | Q28214829 | ||
| Biological control through regulated transcriptional coactivators | Q28287472 | ||
| The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus | Q28344691 | ||
| PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes | Q29547229 | ||
| Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes | Q29614548 | ||
| Metabolic control through the PGC-1 family of transcription coactivators | Q29616509 | ||
| Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes | Q29616567 | ||
| Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice | Q34075210 | ||
| Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. | Q34126257 | ||
| New type of cardiomyopathy associated with diabetic glomerulosclerosis | Q34205051 | ||
| A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. | Q34330003 | ||
| Development of obesity in transgenic mice after genetic ablation of brown adipose tissue | Q34346636 | ||
| Adaptation and maladaptation of the heart in diabetes: Part I: general concepts | Q34592521 | ||
| Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue | Q34631105 | ||
| The diabetic heart: metabolic causes for the development of a cardiomyopathy | Q35660152 | ||
| Transcriptional regulatory circuits controlling mitochondrial biogenesis and function | Q35683727 | ||
| Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. | Q36547048 | ||
| Evidence for cardiomyopathy in familial diabetes mellitus | Q37047581 | ||
| A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice. | Q37387371 | ||
| Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis | Q37526796 | ||
| Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity | Q38319554 | ||
| Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. | Q38321475 | ||
| Myocardial substrate metabolism: implications for diabetic cardiomyopathy | Q40531213 | ||
| Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells | Q40649634 | ||
| Regulation of energy substrate metabolism in the diabetic heart | Q41526636 | ||
| Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study | Q41840439 | ||
| Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart | Q42521720 | ||
| Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial | Q44459441 | ||
| Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes | Q45199109 | ||
| A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes | Q46626385 | ||
| Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. | Q46917083 | ||
| Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes | Q47950327 | ||
| The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins. Medium chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase. | Q52244230 | ||
| Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo. | Q52565864 | ||
| Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity. | Q54071587 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | insulin resistance | Q1053470 |
| preproinsulin | Q7240673 | ||
| P304 | page(s) | 909-917 | |
| P577 | publication date | 2007-01-29 | |
| P1433 | published in | Circulation | Q578091 |
| P1476 | title | Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. | |
| P478 | volume | 115 |
| Q38656290 | A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling. |
| Q35878698 | A murine model of isolated cardiac steatosis leads to cardiomyopathy |
| Q37983012 | A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy |
| Q84911191 | A new twist in the function of the cardiac lipid droplet |
| Q35630386 | ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. |
| Q34008821 | Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1 |
| Q37259538 | Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure |
| Q34424919 | Activation of mitochondrial energy metabolism protects against cardiac failure |
| Q46130828 | Adverse cardiac responses to alpha-lipoic acid in a rat-diabetic model: possible mechanisms? |
| Q89830720 | Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat |
| Q34759986 | Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. |
| Q41600084 | Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats |
| Q39897078 | Alterations in sarcoplasmic reticulum and mitochondrial functions in diabetic cardiomyopathy |
| Q35931589 | Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome |
| Q34085696 | Autophagy in health and disease. 5. Mitophagy as a way of life |
| Q55049902 | Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat. |
| Q27002459 | Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies |
| Q51053064 | Cardiac fatty acid uptake and metabolism in the rat model of polycystic ovary syndrome. |
| Q34043589 | Cardiac remodeling in obesity. |
| Q35196933 | Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation |
| Q36407271 | Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart |
| Q42516922 | Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon. |
| Q34089711 | Coactivators in PPAR-Regulated Gene Expression |
| Q37335886 | Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. |
| Q26997062 | Diabetic cardiomyopathy: bench to bedside |
| Q42560043 | Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload |
| Q38232304 | Epigenetic regulation and heart failure |
| Q36814087 | Free fatty acid oxidation in insulin resistance and obesity |
| Q37223281 | Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia |
| Q30497008 | Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice |
| Q38317335 | Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart |
| Q34193904 | Improvement of mechanical heart function by trimetazidine in db/db mice |
| Q37413593 | Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium |
| Q34441654 | Interaction of TNF with angiotensin II contributes to mitochondrial oxidative stress and cardiac damage in rats |
| Q35169996 | KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation |
| Q47669076 | Kalpaamruthaa ameliorates mitochondrial and metabolic alterations in diabetes mellitus induced cardiovascular damage |
| Q37514855 | Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK. |
| Q38084193 | Mechanisms of subcellular remodeling in heart failure due to diabetes |
| Q34626465 | Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases |
| Q35976043 | Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome |
| Q24633336 | Mitochondria in the diabetic heart |
| Q89878208 | Mitochondrial Mechanisms in Diabetic Cardiomyopathy |
| Q47599571 | Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy |
| Q35057592 | Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. |
| Q53645124 | Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart. |
| Q38946122 | Mitochondrial dysfunction and its impact on diabetic heart |
| Q39005762 | Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies |
| Q33668501 | Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities |
| Q28390863 | Mitochondrial dysfunction in diabetic cardiomyopathy |
| Q36198938 | Mitochondrial dysfunction in white adipose tissue |
| Q28383025 | Mitochondrial function in vascular endothelial cell in diabetes |
| Q46880677 | Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart |
| Q52641719 | Mitochondrial inefficiency in infants born to overweight African-American mothers. |
| Q38688806 | Mitochondrial quality control in the diabetic heart |
| Q36674142 | Molecular and metabolic mechanisms of cardiac dysfunction in diabetes. |
| Q35436264 | Muscle-specific deletion of comparative gene identification-58 (CGI-58) causes muscle steatosis but improves insulin sensitivity in male mice |
| Q39699981 | Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat. |
| Q35243945 | New insights into insulin resistance in the diabetic heart |
| Q33856448 | PET detection of the impact of dobutamine on myocardial glucose metabolism in women with type 1 diabetes mellitus |
| Q37795417 | PGC-1 Coactivators in Cardiac Development and Disease |
| Q27008861 | PGC-1 proteins and heart failure |
| Q58616511 | PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation |
| Q37576286 | PPARs modulate cardiac metabolism and mitochondrial function in diabetes |
| Q37834354 | Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes |
| Q35636191 | Peroxisome proliferator-activated receptors, metabolic syndrome and cardiovascular disease |
| Q38104693 | Perspectives and potential applications of mitochondria-targeted antioxidants in cardiometabolic diseases and type 2 diabetes |
| Q38904958 | Perspectives on the Role and Relevance of Copper in Cardiac Disease |
| Q36605039 | Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart |
| Q27002338 | Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel |
| Q24562914 | Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics |
| Q33675244 | Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators |
| Q39347930 | Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats. |
| Q37995917 | Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies |
| Q37097807 | Role of mitochondrial dysfunction in insulin resistance |
| Q37681949 | Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization. |
| Q42426461 | Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes |
| Q45462968 | The Implication of PGC-1α on Fatty Acid Transport across Plasma and Mitochondrial Membranes in the Insulin Sensitive Tissues. |
| Q33394532 | The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach |
| Q34587748 | The PGC-1 cascade as a therapeutic target for heart failure |
| Q37156948 | The PPAR trio: regulators of myocardial energy metabolism in health and disease |
| Q36426768 | The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium |
| Q37337283 | The Randle cycle revisited: a new head for an old hat. |
| Q26751165 | The association between PGC-1α and Alzheimer's disease |
| Q34437557 | The critical role of Astragalus polysaccharides for the improvement of PPARα [ correction of PPRAα]-mediated lipotoxicity in diabetic cardiomyopathy |
| Q26829731 | The mitochondria in diabetic heart failure: from pathogenesis to therapeutic promise |
| Q35803717 | The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance |
| Q35083219 | Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice |
| Q46108030 | Therapy with Astragalus polysaccharides rescues lipotoxic cardiomyopathy in MHC-PPARα mice |
| Q52371823 | Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication. |
| Q38124617 | Thioredoxin-interacting protein and myocardial mitochondrial function in ischemia-reperfusion injury |
| Q36392834 | Thyroid mimetic as an option for lowering low-density lipoprotein |
| Q35923008 | Transcriptional control of cardiac fuel metabolism and mitochondrial function |
| Q37195072 | Type 2 diabetes, mitochondrial biology and the heart |
| Q35564129 | Updating experimental models of diabetic cardiomyopathy |
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