Adverse cardiac responses to alpha-lipoic acid in a rat-diabetic model: possible mechanisms?

scientific article published on 18 April 2013

Adverse cardiac responses to alpha-lipoic acid in a rat-diabetic model: possible mechanisms? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S13105-013-0252-9
P698PubMed publication ID23595962
P5875ResearchGate publication ID236225237

P2093author name stringNouf M Al-Rasheed
Nawal M Al-Rasheed
Hala A Attia
Iman H Hasan
Raeesa A Mohamad
Maha Al-Amin
Hanaa Al-Ajmi
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Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.Q30359509
alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generationQ33214275
alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged miceQ33900969
Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.Q34011073
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The pharmacology of the antioxidant lipoic acidQ34447239
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New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant TherapyQ35115544
Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trialQ35179957
Free radical-mediated oxidation of free amino acids and amino acid residues in proteinsQ35602220
Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell lineQ35745911
Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathyQ35766956
Oxidative stress and stress signaling: menace of diabetic cardiomyopathyQ36204491
NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure.Q36456363
α-Lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty ratsQ36571926
Antioxidants in the treatment of diabetesQ37835858
Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heartQ38317335
Prooxidant activities of alpha-lipoic acid on oxidative protein damage in the aging rat heart muscleQ40432530
Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat.Q40469766
Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathwayQ41149722
Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acidQ41674964
Early expression of angiogenesis factors in acute myocardial ischemia and infarctionQ41722694
R-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytesQ42818712
Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy.Q43232861
Mechanism of dihydrolipoate stimulation of the mitochondrial permeability transition: effect of different respiratory substratesQ43504434
Thiol oxidase activity of copper, zinc superoxide dismutaseQ43792229
Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidantsQ43841437
The role of advanced oxidation protein products in regulation of dendritic cell functionQ43895324
The amount of thiolic antioxidant ingestion needed to improve several immune functions is higher in aged than in adult mice.Q43985437
Activation of NADPH oxidase during progression of cardiac hypertrophy to failureQ44167921
Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate.Q44243157
Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitusQ44268873
Early oxidative stress in the diabetic kidney: effect of DL-alpha-lipoic acidQ44274282
Ageing exacerbates the cardiotoxicity of hydrogen peroxide through the Fenton reaction in ratsQ44360056
Homocysteine strongly enhances metal-catalyzed LDL oxidation in the presence of cystine and cysteineQ44430794
Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic ratsQ44495010
AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidaseQ44504103
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liverQ45053341
Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishmeQ45883055
Effect of alpha-lipoic acid on LPS-induced oxidative stress in the heart.Q46013820
Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats.Q46120092
Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilizationQ46271034
Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidneyQ46393330
Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depressionQ46408223
Early lipoic acid intake protects retina of diabetic miceQ46496432
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.Q46579574
Plasma protein oxidation in aging rats after alpha-lipoic acid administrationQ46611302
Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidationQ46647777
Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acidQ46705618
Advanced oxidation protein products promote inflammation in diabetic kidney through activation of renal nicotinamide adenine dinucleotide phosphate oxidaseQ46823976
Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits.Q46834219
Effects of alpha-lipoic Acid on body weight in obese subjectsQ47399374
Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetesQ47950327
Effect of alpha-lipoic acid supplementation on trace element levels in serum and in postmitotic tissue in aged ratsQ48167186
Safety evaluation of alpha-lipoic acid (ALA).Q50078015
Streptozotocin- and alloxan-induced diabetes modifies total plasma and lipoprotein lipid concentration and composition without altering cholesteryl ester transfer activity.Q51490915
alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.Q51563349
Alpha-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria.Q52599694
Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.Q54167015
The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle.Q55066548
Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stressQ56608865
Antioxidant Therapy in Diabetic Complications: What is New?Q58829157
Effects of Lipoic Acid and Dihydrolipoic Acid on 4-Aminophenol-Mediated Erythrocytic Toxicity in vitroQ61959370
Advanced oxidation protein products as a novel marker of oxidative stress in uremiaQ71324551
Superoxide as an intracellular radical sinkQ72958737
Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetesQ73572755
Effects of oxidised alpha-lipoic acid and alpha-tocopherol on xenobiotic-mediated methaemoglobin formation in diabetic and non-diabetic human erythrocytes in-vitroQ73925106
Protein oxidative damageQ74042771
Effect of diabetes mellitus on formation of coronary collateral vesselsQ77393455
Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissueQ77531118
alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuriaQ77988248
Lipid peroxidation and antioxidant status in experimental diabetesQ78099436
Alpha-lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activityQ79862188
Effect of chronic restraint stress and alpha-lipoic acid on lipid peroxidation and antioxidant enzyme activities in rat peripheral organsQ79899944
Stimulation of membrane permeability transition by alpha-lipoic acid and its biochemical characteristicsQ80090787
Treatment with Actovegin® improves sensory nerve function and pathology in streptozotocin-diabetic rats via mechanisms involving inhibition of PARP activationQ82155725
Effect of pro- and antioxidants on insulin sensitivity and glucose toleranceQ83218681
General oxidative stress during doxorubicin-induced cardiotoxicity in rats: absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acidQ83592593
Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effectsQ84143689
Role of lipoic acid on insulin resistance and leptin in experimentally diabetic ratsQ84823948
P433issue4
P304page(s)761-778
P577publication date2013-04-18
P1433published inJournal of Physiology and BiochemistryQ15751440
P1476titleAdverse cardiac responses to alpha-lipoic acid in a rat-diabetic model: possible mechanisms?
P478volume69

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cites work (P2860)
Q46293158R-lipoic acid overdosing affects platelet life span via ROS mediated autophagy
Q28397610The effects of crocin, insulin and their co-administration on the heart function and pathology in streptozotocin-induced diabetic rats
Q89274818α-Lipoic Acid in Soluplus(®) Polymeric Nanomicelles for Ocular Treatment of Diabetes-Associated Corneal Diseases

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