Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

scientific article published on 23 February 2009

Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCULATIONAHA.108.792101
P932PMC publication ID2739097
P698PubMed publication ID19237663

P50authorE. Dale AbelQ59100279
Bart C. WeimerQ42290934
Brian T O'NeillQ57755381
P2093author name stringOleh Khalimonchuk
Sheldon E Litwin
Dong Chen
Sihem Boudina
Kenneth J Rodnick
Sandra Sena
Xiaoming Sheng
Heiko Bugger
Jordan J Wright
Olesya Ilkun
Benjamin Wayment
Vlad G Zaha
Ryan Centini
Timothy J Tidwell
Eric Palfreyman
Heather Theobald
Pradip K Mazumder
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Effects of insulin and work on fructose 2,6-bisphosphate content and phosphofructokinase activity in perfused rat heartsQ70023887
Insulin action on glucose transport in cardiac muscleQ70389323
Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the ratQ72364841
Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overloadQ73372293
Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signalingQ81152659
Quantitative proteomic analysis by accurate mass retention time pairsQ81598631
Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterificationQ27887261
Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKsQ28188766
Blue native PAGEQ28296330
Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscleQ28579270
Translocation of the glucose transporter GLUT4 in cardiac myocytes of the ratQ28581995
Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.Q30359509
Cardiac remodeling in obesity.Q34043589
Redox control of iron regulatory proteinsQ34618273
Regulation of the activity of the pyruvate dehydrogenase complexQ34747160
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expressionQ34789045
Glucose transport in the heartQ35650780
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.Q36156412
Myocardial insulin resistance and cardiac complications of diabetes.Q36223473
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.Q36547048
Diabetic cardiomyopathy revisitedQ36860318
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.Q36943690
Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesityQ38319554
Stereological principles for morphometry in electron microscopic cytologyQ39984683
Stabilization of the pyruvate dehydrogenase E1alpha subunit by dichloroacetateQ40994489
Actions of insulin on the mammalian heart: metabolism, pathology and biochemical mechanismsQ41526626
Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heartQ42455921
Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in ratsQ42477638
Overexpression of metallothionein reduces diabetic cardiomyopathy.Q43833575
Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species productionQ44328981
Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetesQ44480693
Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young womenQ44880994
Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.Q45032380
Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 miceQ46818652
Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathyQ46966545
Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetesQ47950327
Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.Q53541654
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
oxidative stressQ898814
preproinsulinQ7240673
P304page(s)1272-1283
P577publication date2009-02-23
P1433published inCirculationQ578091
P1476titleContribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart
P478volume119

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